Determination of Basic Nitrogen in Residues of Crude Oil Distillation Using ATR-FTIR and Chemometric Methods

A method for basic nitrogen determination in residues of crude oil distillation using infrared spectroscopy and chemometrics algorithms was developed. Interval partial least squares, synergy interval partial least squares, and backward interval partial least squares were evaluated for calibration model construction. The samples were divided into a calibration and prediction set containing 40 and 15 samples, respectively. The first derivative with a Savitzky-Golay filter and the mean centered data showed the best results and were used in all calibration models. The backward interval partial least squares algorithm with spectra divided in 60 intervals and combinations of 4 intervals (1407 to 1372; 1117 to 1082; 971 to 936; 914 to 879 cm^?1) showed the best root mean square error of prediction of 0.016 wt%. This calibration model displayed a suitable correlation coefficient between reference and predicted values.     

An Efficient Approach for Preparing Giant Polypeptide Triblock Copolymers by Protein Dimerization

An efficient and convenient approach for preparing a giant polypeptide–poly(ethylene oxide) triblock copolymer architecture of defined structure and composition is reported. This copolymer consists of two long polypeptide chains derived from bovine serum albumin of distinct lengths with stabilizing poly(ethylene oxide) side‐chains, a connecting poly(ethylene oxide) block, and the presence of secondary structure elements along the polypeptide backbone. It is synthesized from the abundant plasma protein serum albumin and the polypeptide backbone is fully biodegradable. This approach represents a convenient and efficient strategy for preparing giant polypeptide‐based block copolymers of defined structure via a semi‐synthetic strategy. Such high‐molecular‐weight, biodegradable copolymers are attractive for various biomedical applications     

Global analysis of an SIS model with an infective vector on complex networks

In this paper, a modified SIS model with an infective vector on complex networks is proposed and analyzed, which incorporates some infectious diseases that are not only transmitted by a vector, but also spread by direct contacts between human beings. We treat direct human contacts as a social network and assume spatially homogeneous mixing between vector and human populations. By mathematical analysis, we obtain the basic reproduction number R₀ and study the effects of various immunization schemes. For the network model, we prove that if R₀<1, the disease-free equilibrium is globally asymptotically stable, otherwise there exists an unique endemic equilibrium such that it is globally attractive. Our theoretical results are confirmed by numerical simulations and suggest a promising way for the control of infectious diseases.     

Capillary zone electrophoresis of basic drugs in non-aqueous acetonitrile with buffers based on a conventional pH scale

Summary The pK _a ^* values of 10 nitrogen-containing basic drugs in non-aqueous acetonitrile were determined from the pH^* dependence of their electrophoretic mobilities. The pH^* scale in the organic solvent was established using background electrolytes with known conventional pK _a ^* values, making further calibration with reference pH electrodes unnecessary. In acetonitrile the pK _a ^* values of analytes (or their conjugated cation acids, BH⁺, respectively) were 5.2±8.9 pK units>those in water. The observed change in pK _a ^* values of cationic analytes was, however, much less than the known respective change for neutral acids type HA. From the pK _a ^* values and the actual mobilities, it is possible to predict pH^* conditions to enable separation of analytes, and this was demonstrated for two pairs of common drugs.     

A novel silica-based column packing for reversed-phase HPLC of basic compounds

Summary A novel bonded phase for reversed-phase HPLC was synthesized in two steps. Octylamine was first reacted with β-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (β-ECTS) and then the intermediate product was coupled onto porous silica. The prepared packing was characterized by elemental analysis, solid-state¹³C NMR and Fourier transform infrared (FT-IR). Chromatographic evaluations were carried out by using a mixture of organic compounds including acidic, basic and neutral analytes and methanol-water as binary mobile phase. The results showed that the stationary phase has excellent chromatographic properties and is resistant to hydrolysis between pH=2≈8. It can be used efficiently for the separation of basic compounds.     

Retention behavior of basic compounds on alkylphosphonate-modified magnesia-zirconia composite stationary phase in RPHPLC

Summary The chromatographic properties of an alkylphosphonate-modified magnesia-zirconia composite stationary phase have been investigated by reversed-phase high-performance liquid chromatography with basic compounds as probes. The influence of organic modifier composition and mobile phase pH was studied. The new stationary phase, similar to a silica-based reversed-phase stationary phase, has hydrophobic properties, but greater pH stability. Use of the phase results in more symmetric peaks for basic compounds. A possible mechanism of retention of basic solutes on the new stationary phase is discussed. The chromatographic behavior of the basic solutes depends mainly on hydrophobic interactions between the solutes and the hydrophobic moiety of the stationary phase. Br?nsted acidic and basic sites on the surface of the new stationary phase play an important role in the retention of ionized solutes by ion-exchange interaction. Promising separations of some basic compounds have been achieved by use of methanolic TRIS buffer, pH 10.0, as the mobile phase.     

凸规划的新算法

对一般凸目标函数和一般凸集约束的凸规划问题新解法进行探讨,它是线性规划一种新算法的扩展和改进,此算法的基本思想是在规划问题的可行域中由所建－的一个切割面到另一个切割面的不断推进来求取最优的。文章对目标函数是二次的且约束是一般凸集和二次目标函数且约束是线性的情形,给出了更简单的算法。     

Fuzzy线性映射

在基本Fuzzy点空间上提出了Fuzzy线性映射的概念,证明了Fuzzy线性映射的表示定理,讨论了Fuzzy线性映射的合成、可逆及保持Fuzzy集合的线性运算等相关性质。     

纤维加强金属基复合材料热机械疲劳模型的研究进展

纤维增强金属基复合材料的热机械疲劳(thermomechanical fatigue 简称TMF)特性的研究在近年受到高度重视.本文根据国内外近期进行的理论研究以及获得的主要成果作一概要介绍.对于热机械循环特性,主要介绍基于细观力学方法的轴向性质模型,以及基于断裂与损伤理论的横向性质模型.对于热机械疲劳性能研究,结合横向性质导出两种热机械疲劳模型,然后分析基体的细观结构对疲劳寿命的影响.      

多肽聚合物合成新方法及生物医学应用

多肽聚合物是以多肽为主链的合成聚合物,由于其固有的生物相容性和生物降解性,在生物医学领域展现出广阔的应用前景,然而多肽聚合物的高效、快速、简便合成仍然具有很大挑战。近年来随着合成化学的快速发展,基于α-氨基酸的N-羧基环内酸酐(NCA)开环聚合法制备多肽聚合物取得了突破性进展,合成了大量基于多肽聚合物的新型材料。本文首先介绍了NCA单体的合成机理及最新改进,然后重点介绍了近年来新发展的NCA开环聚合快速、高效制备多肽聚合物的不同引发或催化体系,最后简要介绍了多肽聚合物在抗菌剂、药物递送及组织工程等领域的应用,并提出了多肽聚合物材料在生物医学领域应用所面临的挑战。