Lateral Phase Mucosal Wave Asymmetries in the Clinical Voice Laboratory

Anecdotally, in some persons it has been observed by the Senior Author (K.K.) that asymmetries of the mucosal wave exist when examined videostroboscopically. In the vast majority of these people, no pathology is ever discovered. Mucosal wave asymmetries could cause concern for the otolaryngologist, who may consider them to be a forewarning of subclinical pathology and subject the patient to unnecessary, expensive, and anxiety-provoking investigations or interventions. The purpose of this study was to establish the prevalence of mucosal wave asymmetries in an asymptomatic population lacking laryngeal pathology. Acoustic spectral analysis is also utilized to determine if the presence of subharmonics might be associated. A hospital-based, cross-sectional study design was used. The subjects had no known vocal or medical pathologies, and were nonsmoking. The study group was composed of 30 males aged 35-50 years and 30 women between 22-55 years. Each of the males underwent acoustic spectral analysis; and all subjects completed a medical questionnaire, subjective talkativeness rating, and videostroboscopic laryngeal examination. 10.5% of the subjects (exact 95% CI = 4.0-21.5%) exhibited mucosal wave variations at stroboscopy, characterized as periodic lateral phase asymmetries found consistently in both the modal and upper registers. There was no association with the chosen acoustic spectral parameters, talkativeness scales, or questionnaire-based variables. Mucosal wave asymmetries may be a variance of normal, and are likely to be far more common in the general population than previously believed. The prevalence detected here is expected to be important in the clinical laryngology practice, where these asymmetries may be frequently encountered and influencing management decisions. There has been little normative data published for variations of the mucosal wave specifically for epidemiological purposes. Clinically, in the absence of such data, otolaryngologists may over interpret videostroboscopic findings, leading to unnecessary investigations or interventions.     

The influence of asymmetry in drop shape on an interfacial tension measurement

A requirement of the drop method for interfacial tension measurement is that the drop must have an axi-symmetry. The drop shape was measured as a function of the angle of the rod from which the drop was hanging. The deviation of the interfacial tension caused by asymmetry was calculated using the selected plane method in the pendant drop technique. A sharp maximum was seen in the interfacial tension vs angle curve when the rod was at the vertical point. The maximum value was concluded as being the true value of the interfacial tension. Both decreases in the pressure difference and in the curvature of the drop associated with an increase in the rod-angle are a counterpart with each other to satisfy the Bashforth and Adams equation. The underestimation of the interfacial tension seems to be caused by the apparent inconsistency between the decreases in the curvature and pressure difference terms. The rigorous mechanical setup demonstrated here is necessary to attain the true axi-symmetric condition, and thus obtain a reliable value for the interfacial tension.     

Asymmetric bipolar membrane: A tool to improve product purity

Bipolar membranes (BPMs) are catalytic membranes for electro-membrane processes splitting water into protons and hydroxyl ions. To improve selectivity and current efficiency of BPMs, we prepare new asymmetric BPMs with reduced salt leakages. The flux of salt ions across a BPM is determined by the co-ion transport across the respective layer of the membrane. BPM asymmetry can be used to decrease the co-ion fluxes through the membrane and shows that the change of the layer thickness and charge density of the corresponding ion exchange layer determines the co-ion flux. The modification of a commercial BP-1 with a thin additional cation exchange layer on the cationic side results in a 47% lower salt leakage. Thicker layers result in water diffusion limitations. In order to avoid water diffusion limitations we prepared tailor made BPMs with thin anion exchange layers, to increase the water flux into the membrane. Therefore a BPM could be prepared with a thick cation exchange layer showing a 62% decreased salt ion leakage through the cationic side of the membrane.     

ASYMMETRY PARAMETERS AND DIFFERENTIAL CROSSSECTIONS FOR PHOTOIONIZATION-EXCITATION OF HELIUM

Asymmetry parameterβ2 for photoionization of helium leaving the He+ ion in the n = 2 level and differential cross sections(DCSs) in the n = 2, 3, 4 levels with photon emission angle θ=90°are provided at photon energies 69－76.8 eV employing the R-matrix method with a 20-term target representation, in which five polarization orbitals 6l are included. The asymmetry parameter β2 and the DCS, in the n=2 level in the region of 69－73eV, are in good agreement with available experimental and theoretical results. Above the n = 3 threshold, we present new theoretical results along with measurements. No theoretical and experimental results can be used to compare with the present calculations of the DCSs for photoionization into the He+ ion in the n = 3, 4 levels.     

基于磁性颗粒微阵列与双色荧光杂交的单核苷酸多态性分型方法研究

基于磁性颗粒微阵列与双色荧光杂交,建立了单核苷酸多态性(Single nucleoitide polymorphism,SNP)分型方法。将利用不对称扩增得到的含有待检测位点生物素标记的单链PCR产物固定在链亲和素修饰的金磁纳米颗粒(Gold magnetic nanoparticles,GMNPs)表面;将ssDNA-GMNPs混合物点样在底部固定有磁铁的载玻片上构建磁性颗粒微阵列,然后在基因框中与双色荧光探针杂交;杂交完全后,充分洗涤,通过扫描获得分型结果。通过优化不对称PCR的扩增条件,直接扩增出产量较高的单链DNA作为靶序列用于分型。利用本方法对24个样本MTHFR基因的C677T位点多态性进行了检测。实验证明,本方法步骤简单,易实现自动化操作、非常适用于分子诊断与法医鉴定。     

Asymmetric angular dependence of Jc in coated conductors prior to and after fast neutron irradiation

Angular dependent measurements of J_c were performed on a commercial coated conductor (SuperPower) consisting of a 1 μm thick YBCO layer grown on a MgO IBAD buffer layer. An asymmetric behavior of the angular dependence of J_c (J_c(Ф)) was found with a changing distance between the two peaks at different temperatures and applied magnetic fields. One peak always occurs when the field is oriented parallel to the tape surface, the other smaller peak is located in the perpendicular orientation at high fields, but slightly shifted (by up to 10°) at 77 K and low magnetic fields. This peak shift, the overall J_c(Ф) asymmetry and the influence of fast neutron irradiation on J_c(Ф) are discussed. The spherical defects, introduced by collisions of fast neutrons with the lattice atoms, are randomly distributed, add to the as-grown defect structure and change the critical current anisotropy by altering both peaks.     

FEL光学速调管的升级性能分析

通过三维磁场的有限元计算,给出了自由电子激光（FEL）研究用光学速调管升级后的磁参数。国家同步辐射实验室合肥光源（HLS）电子储存环能量可以日常运行在200～800 MeV间,为了与电子储存环能量匹配,并在较高束电子能量下进行实验和得到较多的相干辐射光子,光学速调管从原来的对称结构升级成非对称结构,用于HLS储存环谐波产生FEL实验。给出了升级后非对称光学速调管的几组匹配磁参数,用于在HLS储存环注入能量和可以运行的最高能量下进行谐波FEL实验。初步计算表明,HLS 储存环电子束性能优越,能散很低,FEL实验用最高能散仅为2.05×10-4,相应FEL辐射的能散修正因子在0.96以上,可以忽略不计。     

First Asymmetry Synthesis and Stereochemistry of Glutinone

Rencently, two new sesquiterpenoids, glutinone 1 and lucinone 2, were isolated from the aerial parts of traditional medicine2 Jasonia glutinosa1 by Castillo and co-workers3. However, Castillo only gave the structure of glutinone, but its absolute configuration is still unknown. Here, we wish to report our stereoselective construction of the four possible diastereoisomers (9a, 9b, 9c & 9d) of glutinone. By comparing the spectrum data with that of the natural product, we outlined the stereoc…     

组合注入质子导致不对称耦合双量子阱截面混合效应研究

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Asymmetry in transitional pipe flow of drag-reducing polymer solutions

New experimental data are presented and discussed for fully developed pipe flow of shear-thinning, viscoelastic polymer solutions in the transitional regime between laminar and turbulent flow. The data confirm that such transitional flows exhibit significant departures from axisymmetry in contrast to the fully developed pipe flow of Newtonian fluids or both laminar and turbulent flows of such drag-reducing liquids. The azimuthal structure of the asymmetry is investigated together with its axial development and also the velocity fluctuation levels. These data do not lead to an explanation for the asymmetry but do suggest that the influence of the flow geometry both upstream and downstream can be ruled out.