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71.
Wallans Torres Pio dos Santos Edimar Gledison Nascimento de Almeida Humberto Eustáquio Alves Ferreira Denise Tofanello Gimenes Eduardo Mathias Richter 《Electroanalysis》2008,20(17):1878-1883
The present work reports a simple and quick strategy for simultaneous determination of paracetamol (PC) and ascorbic acid (AA) in pharmaceutical formulations using flow injection method with multiple pulse amperometric detection. The method allows the resolution of the mixture without chemical pretreatment of the sample or electrode modification or the use of chemometric techniques for data analysis. The compounds are detected by applying four sequential pulses (waveform) in function of time to a three‐electrode amperometric system that uses a wall‐jet cell with gold as working electrode. AA is direct detected at +0.40 V and PC is indirectly detected at 0.0 V by the reduction (desorption) of the oxidation product (N‐acetyl‐p‐benzoquinoneimine) electrochemically generated at +0.65 V. The fourth potential pulse (?0.05 V) is applied for the complete regeneration (cleaning) of the gold electrode surface. The linear response range was optimized between 5 and 24 mg L?1 for AA and 50 and 240 mg L?1 for PC. The difference between the two responses ranges (10‐fold) present correlation with the concentration of these compounds in two different pharmaceutical formulations available in the Brazilian market. The analytical frequency was calculated in 60 injections per hour. The use of the proposed methodology for PC quantification in the presence of higher AA concentrations was also carried out. Using the standard addition method, it was possible to detect PC in trace levels (LD=0.2 mg L?1) in the presence of 880‐fold more of AA (176 mg L?1). 相似文献
72.
Genetic algorithm (GA) is a suitable method for selecting wavelengths for partial least squares (PLS) calibration of mixtures with almost identical spectra without loss of prediction capacity using the spectrophotometric method. In this study, the concentration model is based on absorption spectra in the range of 200‐320 nm for 25 different mixtures of ascorbic acid (AA) and uric acid (UA). The calibration curve was linear over the concentration range of 1‐15 and 2‐16 μg mL?1 for ascorbic acid and uric acid, respectively. The root mean square deviation (RMSD) for ascorbic acid and uric acid with GA and without GA were 0.3071 and 0.3006, 0.3971 and 0.7063, respectively. The proposed method was successfully applied to the simultaneous determination of both analytes in human serum and urine samples. 相似文献
73.
《Arabian Journal of Chemistry》2023,16(1):104422
A fluorescent nanoprobe based on sodium lignosulfonate derived carbon quantum dots (SLS-CQDs) was fabricated through a facile and sustainable one-step hydrothermal treatment. The obtained SLS-CQDs had excellent fluorescence properties and were applied to detect total Mn and ascorbic acid (AA). The fluorescence of SLS-CQDs could be effectively quenched by Mn based on a static quenching process and recovered by the addition of AA. An “on–off-on” fluorescent nanoprobe was established to determine total Mn and AA with the detection limits of 6.9 µg/L and 0.65 µM with the corresponding linear ranges of 0.25–2.25, 5–25 mg/L, and 5–110 µM, respectively. This nanoprobe could accurately detect total Mn in surface water and AA in Vitamin C effervescent tablet samples. The proposed method is simple and can be performed easily, indicating that SLS-CQDs might be used in environmental monitoring, food and drug testing. 相似文献
74.
The quantification of methyldopa in pharmaceuticals has been carried out using a glassy carbon electrode(GCE) modified with multi-walled carbon nanotubes(MWCNTs). Methyldopa exhibited a quasi-reversible response with a peak potential separation of 473 m V on a bare GCE. However, the cyclic voltammetric behaviour of methyldopa was improved with the increase of the amount of MWCNTs. It was also shown that the electrocatalytic activity of the electrode towards the response of methyldopa was higher with larger amount of film on the surface. The results showed that the peak current was proportional to the concentration of methyldopa with a linear dynamic range of 0.005–0.388 mmol/L and a detection limit of 1.0 nmol/L was obtained using square wave voltammetry. The experimental data showed that the detection limit of methyldopa and peak separation from interfering compounds such as ascorbic acid(AA) and uric acid(UA) were improved using the proposed procedure. The method was successfully applied for the determination of methyldopa in pharmaceuticals. 相似文献
75.
Amanda C. Santos Valtencir Zucolotto Carlos J. L. Constantino Helder N. Cunha José R. dos SantosJr. Carla Eiras 《Journal of Solid State Electrochemistry》2007,11(11):1505-1510
Multilayered nanostructured films have been widely investigated for electrochemical applications as modified electrodes, including
the layer-by-layer (LbL) films where properties such as thickness and film architecture can be controlled at the molecular
level. In this study, we investigate the electrochemical features of LbL films of poly(o-methoxyaniline; POMA) and tetrasulfonated phthalocyanines containing nickel (NiTsPc) or copper (CuTsPc). The films displayed
well-defined electroactivity, with redox pairs at 156 and 347 mV vs SCE, characteristic of POMA, which allowed their use as
modified electrodes for detecting dopamine and ascorbic acid at concentrations as low as 10−5 M.
This paper is dedicated to Prof. Francisco Nart, in memoriam. 相似文献
76.
Production of singlet molecular oxygen (1O2) in the aerobic oxidation of ascorbic acid catalyzed by copper ion was measured and characterized using [4′-(9-anthryl)-2,2′:6′,2″-terpyridine-6,6″-diyl]bis(methylenenitrilo)tetrakis(acetate)-Eu3+ (ATTA-Eu3+) as a highly sensitive and selective time-resolved luminescence probe for 1O2. The 1O2 produced in the reaction was further characterized and confirmed by (i) chemical trapping of 1O2 with 9,10-diphenylanthracene (DPA), the corresponding endoperoxide was detected by HPLC and (ii) spin trapping of 1O2 with 2,2,6,6-tetramethyl-4-piperidinol (TMP-OH), the corresponding free radical of TMP-OH oxide (TMPO) was detected by electron spin resonance (ESR) spectroscopy. The effects of deuterium oxide, sodium azide and histidine on the 1O2 signal were investigated. The mechanism investigation of 1O2 production implied that the ascorbic acid-Cu(I) complex formed in the reaction could be an important intermediate for the 1O2 production. The reaction of ascorbic acid with copper ion monitored by 1H NMR and absorption spectroscopy demonstrated the formation of a copper ion-ascorbic acid complex. Except for Cu2+ and Cu+-ascorbic acid systems, no detectable 1O2 was produced in other transition metal cation-ascorbic acid systems in the studied range. 相似文献
77.
硫堇衍生化自组装膜修饰金电极的电化学性质及其对抗坏血酸的电催化氧化 总被引:6,自引:0,他引:6
将硫堇共价键合到自组装在金电极表面的半胱胺单分子层上,制成了衍生化自组装单分子膜修饰电极,并用电化学方法研究了它的电化学性质.循环伏安图显示其在pH=7.7的磷酸盐缓冲液中,于-0.45~+0.50V(vs.SCE)范围内有2对氧化还原峰.峰电位分别为Epa1=214mV。Epc1=82mV,Epa2=-75mV,Epc2=-160mV(vs.SCE).pH在5.0~9.0范围内,峰1有2个质子参与反应,峰2有1个质子参与反应.它的表面电子转移速率常数ks=0.02S-1.此膜对抗坏血酸的氧化有催化作用,其氧化过电位较在裸金电极上降低了约250mV.催化电流与抗坏血酸的浓度在1.0×10-6~4.0×10-3mol/L范围内呈良好的线性关系.抗坏血酸催化氧化的异相速率常数为2.68×10-3cm/s. 相似文献
78.
79.
GUO Li ping ** 《高等学校化学研究》1999,(1)
IntroductionTransitionmetalhexacyanoferates,PrussianBlue(PB)anditssubstitutedanalogues,suchascobalthexacyanoferate(CoHCF),hav... 相似文献
80.
Ovalbumin-stabilized gold nanoclusters(OVA@AuNCs) were prepared with ascorbic acid as a reducing agent. This strategy could realize the synthesis of water-soluble OVA@AuNCs within 20 min. The asprepared fluorescent probe showed a red fluorescence emission at 630 nm. Moreover, the properties of the OVA@AuNCs were characterized by transmission electron microscope, dynamic light scattering,ultraviolet-visible spectroscopy, fluorescent spectroscopy. Based on the surface electron density decrease-induced fluorescence quenching mechanism, the OVA@AuNCs provided high sensitivity and selectivity for sensing copper ions. A good linear relationship was obtained between the fluorescence intensity of OVA@AuNCs and the concentration of copper ions in the range of 5.0-100.0 μmol/L(R~2=0.999) with a detection limit of 640 nmol/L Furthermore, the rat serum copper contents were determined by using the OVA@AuNCs based assay, indicating great potential of fluorescent probes for application in biological and clinical analysis. 相似文献