Quantitative molecular similarity analysis (QMSA) methods for property estimation: A comparison of property-based,arbitrary, and tailored similarity spaces

Three classes of arbitrary quantitative molecular similarity analysis (QMSA) methods have been computed using atom pairs, topological indices, and physicochemical properties. Tailored QMSA models have been developed using a selected number of TIs chosen by ridge regression. The methods have been applied to the K -nearest neighbor based estimation of log P of two sets of chemicals. Results show that the property-based and tailored QMSA methods are superior to the arbitrary similarity methods in estimating log P of both sets of chemicals     

An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis

Modular construction of an autonomous and programmable multi-functional heterogeneous biochemical circuit that can identify, transform, translate, and amplify biological signals into physicochemical signals based on logic design principles can be a powerful means for the development of a variety of biotechnologies. To explore the conceptual validity, we design a CRISPR-array-mediated primer-exchange-reaction-based biochemical circuit cascade, which probes a specific biomolecular input, transform the input into a structurally accessible form for circuit wiring, translate the input information into an arbitrary sequence, and finally amplify the prescribed sequence through autonomous formation of a signaling concatemer. This upstream biochemical circuit is further wired with a downstream electrochemical interface, delivering an integrated bioanalytical platform. We program this platform to directly analyze the genome of SARS-CoV-2 in human cell lysate, demonstrating the capability and the utility of this unique integrated system.     

Method of primers in calculating the probability of destruction of a unidirectional composite material in tension

A method of primers is elaborated which allows one to calculate the distribution function of durability of a composite material in tension in the reinforcement direction. Integral and differential equations for calculating the probabilities of formation of primers and destruction of a material caused by their formation are presented. Distribution functions of material strength for the parameter of Weibull distribution of fiber strength on the interval 2.1 ≤ β _f ≤ 50.1 are calculated. From the functions, the average values and root-mean-square deviations of material strength are found. The results obtained agree well with calculations by using the structural-imitation simulation. The distribution functions of material strength with a high precision are approximated by the three-parameter Weibull distributions. The distribution parameters are approximated by the linear functions of ln (β_f). __________ Translated from Mekhanika Kompozitnykh Materialov, Vol. 43, No. 6, pp. 823–838, November–December, 2007.     

Non-linear multimodal model for tuned liquid dampers of arbitrary tank geometry

Tuned liquid dampers (TLDs) utilize sloshing fluid to absorb and dissipate structural vibrational energy. Simple TLD tank geometries may not always be feasible due to space limitations. While the non-linear modelling of sloshing fluid is currently limited to tanks of simple geometries, this paper develops a non-linear multimodal model which describes the sloshing behaviour of a fluid in a flat-bottom tank of arbitrary geometry. The mode shapes of the sloshing fluid are found by solving the Helmholtz equation over the tank domain using the finite element method. The Bateman-Luke variational principle is used to develop a system of ordinary differential equations which account for the coupling of the sloshing modes through the non-linear free surface boundary conditions. Damping is incorporated into the model by considering the drag produced on a set of damping screens inserted in the fluid. The system of ordinary differential equations is solved using the Runge-Kutta-Gill Method to predict the wave heights and sloshing forces. In general, the mode shapes in an arbitrary tank will have components in two orthogonal (x- and y-) directions. This out-of-plane behaviour is an important consideration for TLD design. The model is validated with existing models for the special cases of rectangular and circular tanks. Lastly, new shake table tests are conducted on a tank of complex geometry.     

Photonic generation of microwave arbitrary waveforms

In this paper, techniques to generate microwave arbitrary waveforms based on all-fiber solutions are reviewed, with an emphasis on the system architectures based on direct space-to-time pulse shaping, spectral-shaping and wavelength-to-time mapping, temporal pulse shaping, and photonic microwave delay-line filtering. The generation of phase-coded and frequency-chirped microwave waveforms is discussed. The challenges in the implementation of the systems for practical applications are also discussed.     

Joint remote state preparation of arbitrary two-qubit state with six-qubit state

We present a novelty scheme for joint remote preparation of an arbitrary two-qubit state in a probabilistic manner from a spatially separated multi-sender to one receiver. The probability of success regarding this preparation scheme is calculated in both general and some particular cases. Our results show that in general such remote state preparation can be realized with a probability of 1/4. But in several special cases, the probability of success can be improved to 1/2 or even 1.     

用多粒子态进行量子信息分配

我们提出一个用五粒子态将量子信息分裂成几部分的方案。在这个过程中,如果且只有接受者相互合作才能重建初始比特的态。我们所用的量子通道是Bell太和三比特GHZ态的组合态,这些态在实验上都是很容易制备的。这个方案对某些窃听攻击来说是安全的。而且,它还可以用来实现控制的量子隐形传态。     

整形高功率激光装置的任意电脉冲发生器设计(英文)

基于GaAs场效应管电压控制电流和开关的特性,设计了一种任意电脉冲发生器,并成功应用于激光脉冲整形装置。该电脉冲发生器利用超宽带窄脉冲触发多个GaAs场效应管,产生多路负脉冲,通过模拟延时线依次将各路负脉冲延迟一定时间后经微带线耦合输出多路负脉冲叠加的波形;通过多路不同幅度的脉冲堆积效应来获得形状任意可调的整形电脉冲。为了满足惯性约束聚变(ICF)实验中对电脉冲幅度不能过小的要求,在电路的输出端接入增益可调的超宽带电压放大器,使脉冲幅度达到实验要求。利用设计的任意电脉冲发生器实现了脉冲幅度0～5 V可调、脉宽0～10ns可调、时域调节精度为330 ps,整形方波脉冲下降沿为330 ps、上升沿为240 ps。实验结果表明,将产生的电脉冲注入光波导调制器,可获得理想形状的整形激光脉冲,提高激光脉冲的输出能量。     

Sound field separating on arbitrary surfaces enclosing a sound scatterer based on combined integral equations

To eliminate the limitations of the conventional sound field separation methods which are only applicable to regular surfaces, a sound field separation method based on combined integral equations is proposed to separate sound fields directly in the spatial domain. In virtue of the Helmholtz integral equations for the incident and scattering fields outside a sound scatterer, combined integral equations are derived for sound field separation, which build the quantitative relationship between the sound fields on two arbitrary separation surfaces enclosing the sound scatterer. Through boundary element discretization of the two surfaces, corresponding systems of linear equations are obtained for practical application. Numerical simulations are performed for sound field separation on different shaped surfaces. The influences induced by the aspect ratio of the separation surfaces and the signal noise in the measurement data are also investigated. The separated incident and scattering sound fields agree well with the original corresponding fields described by analytical expressions, which validates the effectiveness and accuracy of the combined integral equations based separation method.