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81.
Nicolas Chopin Aude Gouger Stéphane Picot Guillaume Pilet 《Journal of fluorine chemistry》2011,132(10):850-857
The copper(I) catalyzed cycloaddition reaction of N-Boc propargyl amine (dipolarophile) 1 with benzyl azide (1,3-dipole) 2 was found to proceed smoothly in t-BuOH/H2O at room temperature, to furnish the corresponding 1,4-disubstituted-[1,2,3]-triazole-derived N-Boc amine 3 in good yield. Deprotection of 3 with trifluoroacetic acid and addition of the trifluoroacetate salt 4 in the presence of triethylamine, with a series of methoxyvinyl(trifluoromethyl)ketones 10-14, gave the corresponding β-aminovinyl trifluoromethylated ketones 15-19 in moderate to good yields. Two copper(II) complexes, one monomer and one dimer with chlorine double bridge, 20 and 21, respectively, were also prepared and their crystal structure determined. β-Aminovinyl trifluoromethylated ketones 15-17 and complexes 20 and 21 have been screened as potential antifungal agents and the antimalarial activity of 15 and 16 were tested against two Plasmodium falciparum strains (3D7 and W2). 相似文献
82.
Masahiko Isaka Somporn Palasarn Patchanee Auncharoen Somjit Komwijit E.B. Gareth Jones 《Tetrahedron letters》2009,50(3):284-287
Acremoxanthones A and B, novel anthraquinone-xanthone heterodimers with a unique linkage pattern, together with two known compounds, acremonidins A and C, were isolated from the fungus Acremonium sp. BCC 31806. The structures of the acremoxanthones were determined by analysis of 2D NMR and mass spectrometric data. Acremoxanthones and acremonidins exhibited antibacterial, antifungal, antiplasmodial, and cytotoxic activities. 相似文献
83.
Mudasir A. Tantry Gulzar A. Bhat Ahmed Idris Javid A. Dar Suliman Yousef Al Omar Khalid Z. Masoodi Bashir A. Ganai Azra N. Kamili Abdul S. Shawl 《Helvetica chimica acta》2014,97(11):1497-1506
The hydroalcoholic (EtOH/H2O) extract of matured leaf margins of lemon balm (Melissa officinalis L.) afforded a new 3,23‐disulfate of 2α,3β‐23,29‐tetrahydroxyolean‐12‐en‐28‐oic acid 28‐O‐β‐D ‐glucopyranoside ( 1 ) and a new 23‐monosulfate of 2α,23‐dihydroxyurs‐12‐en‐28‐oic acid 3‐O‐β‐D ‐glucopyranoside ( 2 ), along with six known compounds, i.e., 23‐monosulfate of 2α,3β,19α,23‐tetrahydroxyurs‐12‐ene‐28‐oic acid 28‐O‐β‐D ‐glucopyranoside ( 3 ), 3,5,6‐trihydroxydehydro‐α‐ionol 9‐O‐β‐D ‐glucopyranoside ( 4 ), quadranoside III ( 5 ), rosmarinic acid ( 6 ), caffeic acid ( 7 ), and luteolin ( 8 ). All the isolated compounds were evaluated for their antioxidant, antimicrobial, antimalarial, and cytotoxic activities. Only rosmarinic acid exhibited substantial antioxidant and antimicrobial activities, whereas sulfated terpenes showed considerably lower or no antimicrobial activity. 相似文献