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101.
102.
Dr. Xiong‐Jie Jiang Dr. Janet T. F. Lau Dr. Qiong Wang Prof. Dennis K. P. Ng Prof. Pui‐Chi Lo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(24):8273-8281
A diiodo distyryl boron dipyrromethene (BODIPY) core was conjugated to two ferrocenyl quenchers through acid‐labile ketal and/or thiol‐cleavable disulfide linkers, of which the fluorescence and photosensitizing properties were significantly quenched through a photoinduced electron‐transfer process. The two symmetrical analogues that contained either the ketal or disulfide linkers could only be activated by a single stimulus, whereas the unsymmetrical analogue was responsive to dual stimuli. Upon interaction with acid and/or dithiothreitol (DTT), these linkers were cleaved selectively. The separation of the BODIPY core and the ferrocenyl moieties restored the photoactivities of the former in phosphate buffered saline and inside the MCF‐7 breast cancer cells, rendering these compounds as potential activable photosensitizers for targeted photodynamic therapy. The dual activable analogue exhibited the greatest enhancement in intracellular fluorescence intensity in both an acidic environment (pH 5) and the presence of DTT (4 mm ). Its photocytotoxicity against MCF‐7 cells also increased by about twofold upon preincubation with 4 mm of DTT. The activation of this compound was also demonstrated in nude mice bearing a HT29 human colorectal carcinoma. A significant increase in fluorescence intensity in the tumor was observed over 9 h after intratumoral injection. 相似文献
103.
《Analytical letters》2012,45(14):2159-2171
A simple method was developed for the determination of hydrophilic whitening agents (ascorbyl glucoside, magnesium ascorbyl phosphate, arbutin, hydroquinone, and kojic acid) in bleaching cosmetics by high performance liquid chromatography with electrochemical detection. The samples were prepared using microdialysis and were separated within ten minutes using isocratic elution. Linear calibration was achieved for concentrations between 0.10 and 10.00 micromolar. The limits of detection were from 0.6 to 2.0 nanomolar; the recoveries were between 91.43 and 108.04 percent, and the relative standard deviation was less than 6.88 percent. This method was used to determine whitening compounds in several cosmetics with on-line microdialysis and the zero net flux method. The procedure was fast, simple, selective, and suitable for routine analysis. 相似文献
104.
105.
《Helvetica chimica acta》2017,100(9)
The full details of mechanistic investigation on enantioselective sulfenofunctionalization of alkenes under Lewis base catalysis are described. Solution spectroscopic identification of the catalytically active sulfenylating agent has been accomplished along with the spectroscopic identification of putative thiiranium ion intermediates generated in the enantiodetermining step. The structural insights gleaned from these studies informed the design of new catalyst architectures to improve enantioselectivity. In addition, structural modification of the sulfenylating agents had a significant and salutary effect on the enantioselectivity of sulfenofunctionalization which was demonstrated to be general for trans disubstituted alkenes. Whereas electronic modulation had little effect on the rate and selectivity, steric bulk on arylsulfenylphthalimides was very beneficial. 相似文献
106.
K. K. Vijaya Raj B. Narayana 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1971-1981
A smooth one-step synthesis of 2-(2-bromo-5-methoxyphenyl)-5-(3-arylidene)-1,3-thiazolo[3,2-b]-1,2,4-triazol-6-(5H)-ones (4a–n) is described. The newly prepared compounds are characterized by analytical and IR, 1 H NMR, 13 C NMR, and FABMS spectral analysis. A few compounds are screened for anticonvulsant activity. Compounds 4i and 4n exhibit promising anticonvulsant activity and are recommended for further studies. 相似文献
107.
DIHALOCARBENE ADDITION TO ARYLSUBSTTTUTED VINYL PHOSPHATES UNDER PHASE TRANSFER CATALYTIC CONDITIONS
Imre Petneházy György Keglevich László Tőke 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-2):77-82
Abstract Dihalocarbene addition to aryl-substituted vinyl phosphates was carried out both in solid-liquid and in liquid-liquid two phase systems. The dihalocyclopropane adducts of vinyl phosphates could be obtained in better yield using dihalocarbenes generated by the latter method and no hydrolysis of the vinyl phosphate and of the adduct occurred under these circumstances. Eighteen new vinyl phosphate-dihalocarbene adducts were synthetized and characterized. 相似文献
108.
Marie-Christine Brochier Salon Mohamed Naceur Belgacem 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):240-254
Abstract The hydrolysis kinetics of 14 alkoxy silane coupling agents were carried out in an ethanol:water 80:20 (w/w) solution under acidic conditions and were monitored by 1H, 13C, and 29Si NMR spectroscopy. Acidic conditions were selected in order to enhance the silanol formation and to slow down the self-condensation between the resulting hydrolysed silanol groups. In situ 29Si NMR spectroscopy allowed the determination of the intermediate species as a function of the reaction time. Thus, the following silane coupling agents were studied: 3-methacryloxypropyl trimethoxy silane (MPMS), 3-mercaptopropyl trimethoxy silane (MRPMS), 3-cyanopropyl triethoxy silane (CPES), triethoxy vinyl silane (VES), trimethoxy (2-phenylethyl) silane (PEMS), octyl triethoxy silane (OES), trimethoxy (7-octen-1-yl) silane (OEMS), 3-aminopropyl triethoxy silane (APES), 3-aminopropyl trimethoxy silane (APMS), 3-(2-aminoethylamino)propyl trimethoxy silane, (DAMS), 3-[2-(2-aminoethylamino)-ethylamino]propyl trimethoxy silane (TAMS), 4-amino-3,3-dibutyl trimethoxy silane (ADBMS), trimethoxy [3-(phenylamino)propyl] silane (PAPMS), and triethoxy-3-(2-imidazolin-1-yl) propyl silane (IZPES). A parameter quantifying the grafting potentiality of each silane coupling agent towards OH-rich solid substrates (such as cellulose) was established as a function of the nature of the alkoxy groups (methoxy or ethoxy), as well as that of the fourth substituent (vinyl, aminopropyl, etc.) of the silane studied. GRAPHICAL ABSTRACT 相似文献
109.
Jin Young Lee Yong Han Lee Yong Gwan Byun 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):641-649
Abstract A new (E)-pyrene-1-carbaldehyde O-tert-butyldimethylsilyl oxime 3 was synthesized for the detection of chemical warfare nerve agents, O-isopropyl methylphosphonofluoridate (GB) and O-pinacolyl methylphosphonofluoridate (GD). 1H NMR spectrum showed that the tert-butyldimethylsilyl (TBDMS) group was deprotected using TBAF and the oximate supernucleophile was made. Upon addition of chemical warfare agents (GB and GD) (50 mol%), the reaction was completely finished within 5 min and also the color change of reaction mixture was observed under a hand-held UV lamp with the naked eye. 相似文献
110.
Dušica B. Stojanović Milorad Zrilić Radmila Jančić‐Heinemann Irena Živković Aleksandar Kojović Petar S. Uskoković Radoslav Aleksić 《先进技术聚合物》2013,24(8):772-776
New forms of hybrid multiaxial nanocomposites with enhanced mechanical and stab resisting properties are presented. This study is motivated by the lack of knowledge in the study of the multiaxial fabric nanocomposites with two modified thermoplastic matrices for antiballistic protection. Introduction of 5 wt.% silica nanoparticles in the composite of polyurethane/p‐aramid/poly (vinyl butyral) leads to significant improvement in mechanical properties, and the addition of silane as a coupling agents and glutaraldehyde as a crosslinking agents yielded maximal values of storage modulus, tensile modulus and anti‐stabbing properties for hybrid nanocomposites. Ballistic resistance testing and penetration depth of the hybrid nanocomposites were visualized using image analysis. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献