Zur Synthese von fungizid wirksamen Isocamphanderivaten: Synthesen in der Isocamphanreihe, 34. Mitt.

Summary Some esters of isocamphenilanic acid (4) have been prepared and tested for their fungicidal and insecticidal activity. Esters of various acids with isocamphanyl ethylalcohol (5) have also been synthesized and included in the fungicidal/acaricidal/insecticidal screening programme. All esters bear a geminal dimethyl group at C-3 of the bicyclus which is important because of its shielding effect.

     

4-hydroxy-2-quinolones. 110. Bromination of 1-r-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides

1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides have been prepared. It has been shown experimentally that these compounds are brominated by molecular bromine in glacial acetic acid at position 4 of the anilide fragment. The antitubercular properties of the compounds synthesized are discussed. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1508–1516, October, 2006.     

Hygrometric Determination of Water Activities and Osmotic and Activity Coefficients of NH4Cl–LiCl–H2O at 25°C

The mixed aqueous electrolyte system of ammonium and lithium chlorides has been studied by the hygrometric method at 25°C. The relative humidities of this system are measured at total molalities from 0.3 to 6 mol-kg^{– 1} for different ionic-strength fractions y of NH₄Cl with y = 0.33, 0.50, and 0.67. The data obtained allow the deduction of new water activities and osmotic coefficients. The experimental results are compared with the predictions of the ECA (extended composed additivity) law proposed in our previous work. The Zdanovskii–Stokes–Robinson (ZSR), the Robinson–Stokes (RS), Reilly–Wood–Robinson (RWR), the Pitzer, and the Lietzke–Stoughton (LS II) models are also compared with our results. Predictions made using these models are, in general, consistent with our results. From these measurements, new Pitzer mixing ionic parameters are determined and used to predict the solute activity coefficients in the mixture for different ionic-strength fractions.     

铁轴草中Teucvidin的衍生物研究

从唇形科植物铁轴草中分离得去甲克罗烷二萜化合物Ｔｅｕｃｖｉｄｉｎ，通过催化氢化、酯交换、水解等反应合成了８个衍生物，用＾１ＨＮＭＲ、ＭＳ和ＩＲ确定了其结构，初步生物活性测定结果表明，化合物Ⅱ和Ⅳａ的拒食作用显著。     

Aqueous Solubilities, Infinite Dilution Activity Coefficients and Octanol–Water Partition Coefficients of Tricyclic Analogs of Acyclovir

Solubilities of tricyclic analogs of acyclovir have been determined in water at 25, 35, and 45°C and in octanol, water-saturated octanol, and octanol-saturated water at 25°C. Octanol-water partition coefficients were determined at 25°C. Melting temperatures and molar enthalpies of fusion were measured. Activity coefficients in water, octanol, and in aqueous octanol solutions were determined and are discussed. The effect of hydrophilic and hydrophobic substituents in the tricyclic analogs on their thermodynamic properties are discussed. The standard Gibbs energy of transfer between the saturated phases were found to correlate with known values of the melting point of the solvents and the solubilities of the solute. For a number of the compounds examined, correlations between the minimum inhibitory concentration against the herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella-zoster virus (VZV), thymidine kinase-deficient (TK^–) strains of VZV and were established. Detailed conclusions have been derived concerning the relationships between the structure and the thermodynamic parameters of the compounds examined.     

2-羟丙基三甲基氯化铵壳聚糖的制备及其性能研究

以脱乙酰度为95.37%的壳聚糖(CTS)为原料,异丙醇为溶剂,2,3-环氧丙基三甲基氯化铵为改性剂,于80℃反应12 h合成了水溶性季铵盐2-羟丙基三甲基氯化铵壳聚糖(HACC)。HACC的吸水保水性是CTS的2倍～3倍,加入化妆品中培养2周后菌落总数少于100 CFU.g-1。     

Synthesis and biological activity of certain amino-derivatives of 5α-steroids

Certain 17β-aminoderivatives of 5α-steroids based on tigogenin were synthesized and their antitumor activity was studied. The structures of the synthesized compounds were confirmed by NMR and IR spectroscopy and mass spectrometry. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 263–265, May–June, 2006.     

γ－芳基取代烯丙醇菊酯的合成及杀虫活性

γ－芳基取代烯丙醇菊酯的合成及杀虫活性陈亚娟，黄润秋，马军安（南开大学元素有机化学研究所，天津，３０００７１）关键词γ－芳基取代烯丙醇，拟除虫菊酯，杀虫活性第一个人工合成除虫菊酯烯丙菊酯保留了天然除虫菊酯醇部分的环戊烯醇酮结构，至今仍广泛用作卫生杀虫...     

Synthesis and properties of a poly(diphenylacetylene) containing carbazolyl groups

1-(p-N-Carbazolylphenyl)-2-phenylacetylene (p-CzDPA) was polymerized by TaCl₅–co-catalyst systems (cocatalysts: n-Bu₁Sn, Et₃SiH, and 9BBN) to produce acetone-insoluble polymers in about 60-70% yields. Poly(p-CzDPA) was a yellowish-orange solid, most part of which was soluble in toluene, chloroform, etc., and its weight-average molecular weights were around 4×10⁵. This polymer formed a tough film by solution casting, and was thermally very stable (the onset temperature of weight loss in TGA in air 470°C). The oxygen per-meability coefficient of the polymer at 25°C was lower than two barrers. The present polymer showed photoconductivity and redox activity. © 1995 John Wiley & Sons, Inc.     

A New and Efficient Synthetic Method and Antibacterial Activities of Oxazolidinone Analogues

A series of novel oxazolidinone analogues were prepared by a new and efficient synthetic method and their antibacterial activities were determined. These compounds wer echaracterized by LC-MS and ^1H NMR.