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101.
One‐stage synthesis of N‐substituted 2‐amino‐5‐(2,4‐dihydroxyphenyl)‐1,3,4‐thiadiazoles is described. The compounds were prepared by the reaction of the sulfinyl bis(2,4‐dihydroxythiobenzoyl) (STB) with 4‐substituted 3‐thiosemicarbazides. STB was obtained from 2,4‐dihydroxybenzenecarbodithioic acid and thionyl dichloride. The structure of compounds was confirmed by IR, 1H NMR, 13C NMR, and EI‐MS data. 相似文献
102.
M. J. Medina-Hernández M. Catalá-Icardo M. C. García-Alvarez-Coque 《Chromatographia》1995,41(5-6):455-461
Summary Hydrophobic character is usually expressed in terms of the partition coefficient in 1-octanol-water (log Po/w). However, measurement of this coefficient is often problematic. Retention in micellar liquid chromatography is mainly due
to hydrophobic interactions and can also be used as an index of hydrophobicity. A hydrophobicity scale was established with
retention data foro-phthalaldehyde (OPA)-N-acetyl-L-cysteine (NAC) amino acid derivatives, using the glycine derivative as reference. Since the
OPA-NAC derivatives only differ in the nature of R1 in the amino acid (R1CH (COOH)NH2), in the absence of electrostatic interactions the hydrophobic character of the substituent was responsible for retention.
Linear relationships were obtained between log of the ratiok′ of amino acid derivatives:k′ of the glycine derivative for a given mobile phase, and logP
o/w for the R1 substituent. Good correlations were also found for phenylthiohydantoin amino acid derivatives. 相似文献
103.
用原子吸收分光光度法和氨基酸自动分析仪法分别测定兔血清锌浓度和血清L-赖氨酸含量.结果表明.L-赖氨酸锌中锌的相对生物利用度明显优于硫酸锌.而其中的L-赖氨酸的相对生物利用度与L-赖氨酸组比较无明显差异. 相似文献
104.
川芎嗪对脑缺血下大鼠纹状体区痕量氨基酸类神经递质的影响 总被引:4,自引:1,他引:4
采用脑内微透析技术结合激光诱导荧光检测的高效毛细管电泳研究了脑缺血下盐酸川芎嗪注射液对大鼠纹状体区氨基酸类神经递质含量的影响.在优化的分离条件下,各氨基酸在1×10-6-1×10-8mol/L的浓度范围内与荧光强度呈良好的线性关系,线性相关系数达到0.99以上,检测限低于1.6×10-9mol/L,适合于大鼠纹状体区微透析样品中的痕量氨基酸类神经递质的测量.实验结果表明,脑缺血时,使用盐酸川芎嗪注射液可显著降低细胞外兴奋性氨基酸神经递质谷氮酸(G lu)和天门冬氨酸(Asp)的浓度(P<0.05),同时可显著升高抑制性氨基酸神经递质γ-氨基丁酸(GABA)和甘氨酸(G ly)的浓度(P<0.05).这一结果将对阐明盐酸川芎嗪注射液治疗缺血性脑血管疾病的有关机理提供帮助. 相似文献
105.
Qiuyun Wang Yajin Xiong Baozhu Lu Jun Fan Sheng Zhang Shengrun Zheng Weiguang Zhang 《Journal of separation science》2013,36(8):1343-1348
N‐(2,4‐dinitrophenyl)‐proline and N‐(2,4‐dinitrophenyl)‐serine were enantiomerically resolved on the BSA chiral stationary phase by HPLC in reversed‐phase mode. Effects of chromatographic conditions on enantioseparation and elution order have been investigated in detail. For these two samples, reversal of enantiomer elution order was observed by changing buffer pH, the content of acetonitrile, or alcohol modifiers in mobile phase, which is firstly reported in the BSA chiral stationary phase studies. More interestingly, combined effect between buffer pH and the content of acetonitrile was also observed. In addition, coelution range of enantiomers varied along with the content of acetonitrile in mobile phase. 相似文献
106.
一种新型双核Cu配合物的电化学性质及其应用研究 总被引:1,自引:0,他引:1
本文研究了一种新型平面双核Cu配合物 (deCu)的电化学性质及其修饰电极在水溶液中对半胱氨酸和L_色氨酸的电催化作用 .悬汞电极循环伏安曲线示出 ,在 - 0 .5V和 - 0 .2 5V处显示的还原峰分别对应于配体和配合物中心金属离子的还原反应 .光谱电化学实验进一步表明 :电位价跃至 - 0 .75V时 ,在 4 40nm处出现Cu(Ⅱ )向低价铜的电子跃迁吸收峰 ,而紫外光谱在 2 70和 2 80nm两处出现的吸收峰红移 ,这可能是因为配合物分子氧桥联发生配位形成大偶合体系所致 .利用循环伏安法制备deCu/GC和deCu/石墨碳修饰电极 ,实验表明 ,该修饰电极修饰膜的氧 /还反应为 2电子 2质子过程 ,并对半胱氨酸和L_色氨酸等具有较好的电催化氧化效果 相似文献
107.
The first examples of lariat calix[4]-1,3-aza-crowns with chiral amino acid groups as branched chains (5a and 5b) were designed and synthesized via a 1 + 1 addition reaction of calix[4]-1,3-substituted benzaldehyde derivative (4) and amino acid hydrazide derivatives (3a and 3b) in yields of 70% and 75%, respectively. The preliminary extraction experiments suggested that hosts 5a and 5b possessed good complexation abilities for α-amino acids. 相似文献
108.
Triciribine (TCN, 1) and its monophosphate (TCNP, 2) are tricyclic nucleotide derivatives that have potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signaling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Both TCN and TCNP have very low bioavailability, and the development of both drugs as intravenous (IV) treatments was halted because of the toxicity induced by the high doses needed for their use as general cytotoxic agents. This publication describes an expedient and straightforward total synthesis of amino acid prodrugs (3, 4) of TCN and TCNP. In our study, both the prodrugs significant improved the plasma exposure of the parent drugs and the prodrugs. 相似文献
109.
A simple and efficient synthetic route of 2′‐amino‐2′‐deoxyuridine was studied. 2′‐Amino‐2′‐deoxyuridine was incorporated into 1,8‐naphthalimides in the 2′‐position of 2′‐sugar via linking arms of different lengths. A convenient method for the synthesis of the conjugates was adopted. 相似文献
110.
The separation characteristics of alkylchloroformate-derivatised amino acids (AAs) by using comprehensive two-dimensional gas chromatography (GC×GC) is reported. The use of a low-polarity/polar column set did not provide as good a separation performance as that achieved with a polar/non-polar column set, where the latter appeared to provide less correlation over the separation space. The degree of component correlation in each column set was estimated by using the correlation coefficient (r2; for 1tR and 2tR data) with the low-polarity/polar and polar/low-polarity sets returning correlation coefficients of 0.86, and 0.00 respectively, under the respective conditions employed for the experiments. The 1.5-m non-polar 2D column (0.1-mm ID; 0.1-m film thickness) gave peak halfwidths of the order of 50–80 ms. Linearity of detection was good, over a three order of magnitude concentration range, with typical lower detection limit of ca. 0.01 mg L–1, compared with 0.5 mg L–1 for normal GC operation with splitless injection. The method was demonstrated for analysis of AAs in a range of food and beverage products, including wine, beer and honey. The major AA in these samples was proline. The Heineken beer sample had a relatively more complex and more abundant AA content compared with the other beer sample. The wine and honey samples also gave a range of AA compounds. Repetition of the sample preparation/analysis procedure for the honey sample gave acceptable reproducibility for individual AAs. 相似文献