Quantitative evaluation on oil diffusion mechanisms in nano‐organic‐montmorillonite modified caster oil‐based polyurethane foam for oil/water separation

To improve the oil absorbency of caster oil‐based polyurethane foam, nano‐organic‐montmorillonite (OMMT) was used for the additives. The aim of this study is to evaluate the oil diffusion mechanism and dispersion uniformity of OMMT modified caster oil‐based polyurethane (MPU) using experiments and molecular dynamic simulation. Molecule movement and molecule trajectory of oil was investigated by molecular dynamic simulation and numerical simulation. According to the quantitative analyzing results, the diffusion model was put forward. The average diffusion coefficient of crude oil in 0, 1, 2 wt%, 4, and 6 wt% MPU is 2.4 × 10^?4 cm²/s, 2.6 × 10^?4 cm²/s, 3.0 × 10^?4 cm²/s, 3.2 × 10^?4 cm²/s, and 3.3 × 10^?4 cm²/s, respectively. It indicated that crude oil appeared gradient in the MPU. The optimal diffusion direction of crude oil is (0, 0, 1) crystal face, and the small particles of crude oil are easy to be adsorbed. The two‐dimensional diffusion trajectory of crude oil is nonlinear. The diffusion model includes the diffusion of crude oil at the interface of oil and polyurethane, surface diffusion and pore diffusion, and pore adsorption. Furthermore, the diffusion model showed that the van der Waals force was the main reason for crude oil diffusion or adsorption. OMMT could improve the ability of oil/water separation of polyurethane.     

Evaluation of an Element-Tagged Duplex Immunoassay Coupled with Inductively Coupled Plasma Mass Spectrometry Detection: A Further Study for the Application of the New Assay in Clinical Laboratory

Background: Element-tagged immunoassay coupled with inductively coupled plasma mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis for multiplex detection. However, a further study referring to the standard evaluation and clinical sample verification is needed to ensure its reliability for simultaneous analysis in clinical laboratories. Methods: Carcinoembryonic antigen (CEA) and α-fetoprotein (AFP) were chosen for the duplex immunoassay. The performance of the assay was evaluated according to guidelines from the Clinical and Laboratory Standards Institute (CLSI). Moreover, reference intervals (RIs) of CEA and AFP were established. At last, 329 clinical samples were analyzed by the proposed method and results were compared with those obtained with electrochemiluminescent immunoassay (ECLIA) method. Results: The measurement range of the assay was 2–940 ng/mL for CEA and 1.5–1000 ng/mL for AFP, with a detection limit of 0.94 ng/mL and 0.34 ng/mL, respectively. The inter-assay and intra-assay imprecision were all less than 6.58% and 10.62%, respectively. The RI of CEA and AFP was 0–3.84 ng/mL and 0–9.94 ng/mL, respectively. Regarding to clinical sample detection, no significant difference was observed between the proposed duplex assay and the ECLIA method. Conclusions: The ICP-MS-based duplex immunoassay was successfully developed and the analytical performance fully proved clinical applicability. Well, this could be different with other analytes.     

基于泰勒展开的二阶层次分析法初探

经典AHP常用于武器装备效能或能力评估,然而经典AHP采用线性加权模型,即通过底层指标效能线性加权得到顶层指标效能,对非线性体系往往会引入较大评估误差,易产生决策性错误。为解决这一问题,本文以底层指标效能值等于1/2为展开点,给出基于泰勒展开的二阶加权模型,对线性体系,二阶加权模型可退化为经典线性加权模型;推导出二阶AHP的数学表达式,给出二阶AHP效能评估步骤,构建二阶AHP的基本框架。算例表明,二阶AHP评估结果相比经典AHP更接近于解析解,产生决策性错误的机率远小于经典AHP。     

Design,Synthesis, and Cytotoxic Activity of Novel Natural Arylsulfonamide-Inspired Molecules

Primary arylsulfonamide functional groups feature prominently in diverse pharmaceuticals. However, natural arylsulfonamides are relatively infrequent. In this work, two novel arylsulfonamide natural products were first synthesized, and then a series of novel molecules derived from natural arylsulfonamides were designed and synthesized, and their in vitro cytotoxic activities against A875, HepG2, and MARC145 cell lines were systematically evaluated. The results indicate that some of these arylsulfonamide derivatives exhibit significantly good cytotoxic activity against the tested cell lines compared with the control 5-fluorouracil (5-FU), such as compounds 10l, 10p, 10q, and 10r. In particular, the potential molecule 10q, containing a carbazole moiety, exhibited the highest inhibitory activity against all tested cell lines, with IC₅₀ values of 4.19 ± 0.78, 3.55 ± 0.63, and 2.95 ± 0.78 μg/mL, respectively. This will offer the potential to discover novel drug-like compounds from the sparsely populated area of natural products that can lead to effective anticancer agents.     

高效毛细管电泳法测定二氢叶酸还原酶活力的研究

通过胶束电动毛细管电泳法研究分离二氢叶酸还原酶体系中二氢叶酸、四氢叶酸、 NADP、 NADPH和酶5种组分,在含0.002%Brij-35的pH 9.18 50 mmol/L 的硼砂缓冲溶液中,5种组分在18min内得到基线分离.通过对其产物四氢叶酸峰面积的定量测定,计算出二氢叶酸还原酶的米氏常数,建立了毛细管电泳法对二氢叶酸还原酶活力的测定方法.     

反相高效液相色谱法测定Arthrobacter sp.黄嘌呤氧化酶活性

报道了采用反相高效液相色谱法(RP-HPLC)测定节杆菌(Arthrobacter sp.)黄嘌呤氧化酶活性的有效方法. 将酶初提液与含有黄嘌呤的反应体系在37 ℃下反应20 min, 反应终止后通过HPLC测定产物尿酸生成量的变化来分析酶的活性. 通过流动相组成、pH和柱温等分离条件的优化, 确定了最佳的色谱检测条件以NH4H2PO4 (50 mmol/L, pH 7.5)溶液为流动相, 流速1 mL/min, 柱温25 ℃, 检测波长290 nm. 为深入研究微生物细胞内黄嘌呤氧化酶提供了高效检测手段.     

热力法开采地层天然气水合物的热动力评价

本文在推导热力作用下水合物地层温度分布基础上,发展了评价热力法开采天然气水合物的热效率(用于水合物分解的热量与输入总的热量之比)和能量效率(即输出能量与输入能量之比)的模型.模型分析表明,水合物地层热物性参数以及水合物饱和度决定了热力法开采的能量效率.在注入蒸汽开采初始条件下,能量效率可以达到7.0.     

Synthesis, Mass Spectrometric Studies, and Biological Evaluation of 3,5-Dimethoxyhomophthalic Acid and Related Compounds

3,5-Dimethoxyhomophthalic acid was synthesized in four steps from 3,5-dimethoxycinnamic acid via a series of reactions including cyclization of 3-(3',5'-dimethoxyphenyl)propionic acid to 5,7-dimethoxy-1-indanone and oxidative decomposition of methyl-2-hydroxy-2-[5,7-dimethyoxy-1-oxo-1H-inden-2(3H)-ylidene]acetate to 3,5-dimethoxyhomophthalic acid.The synthesized compounds were characterized by elemental analysis,IR,1H NMR,and MS.The biological evaluation experiments of 3,5-dimthoxyhomophthalic acid and the related synthesized compounds were also carried out.Naturally occurring biologically active isocoumarins were prepared in a single step by the condensation of the homophthalic acid with appropriate acid chlorides.     

大型综合医院室外声景观评价影响因素分析——以长沙市中心医院为例

大型综合医院室外本是医患康复疗养、舒缓身心的场所,但并未引起足够的重视,噪声影响严重,声景观较差.该文以长沙市中心医院为例,通过定点实测结合问卷调查的方式,探究影响大型综合医院室外声景观评价结果的因素.结果表明:长沙市中心医院室外声景观整体满意度一般,语义词调查结果整体偏向贬义负值,受访者身份、调查时间和声源构成对声景...     

SQUID用于铍材残余应力检测的计算机模拟

依据SMM-601型超导量子干涉显微镜检测部分构建计算模型,采用电磁场有限元方法分析了残余应力引起的非磁性金属材料铍电导率变化对超导量子干涉仪(SQUID)检测信号的影响,并讨论了该方法实际应用于非磁性金属材料残余应力检测的条件和可能性。