Synthese und Geruch von Tricyclo[6.2.2.02, 7]dodecan-Derivaten

Summary The acetale-ketone9 was synthesized as precursor for the preparation of -santalol derivatives posessing a bicyclo[2.2.2]octane nucleus. After methylenation of the keto-group the subsequent acidic hydrolysis of the acetal leads via a Prins reaction of the liberated aldehyde with the methylene group to tricyclo[6.2.2.0^{2, 7}]dodecane derivatives. Their olfactory properties are described.

     

Synthesis of 5-glycopyranosylamino-pyrano[2,3-d]pyrimidin-2-one derivatives

Summary Three series of 3-substituted 5-glycopyranosylamino pyrano[2,3-d]pyrimidin-2-one derivatives,3 a–c,4 a–c, and5 a–c have been prepared by treatment of the corresponding 1,4-dihydro-6-glycopyranosylamino pyrimidin-4-ones1 a–c with malonic, methyl malonic and ethyl malonic acids, respectively.

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Synthese von Derivaten des 5-Glucopyranosylaminopyrano[2,3-d]pyrimidin-2-on

Zusammenfassung Es wurden drei Serien von 3-substituierten 5-Glucopyranosylaminopyrano[2,3-d]pyrimidin-2-onen (3 a–c,4 a–c und5 a–c) mittels Behandlung der entsprechenden 1,4-Dihydro-6-glucopyranosylamino-pyrimidin-4-one (1 a–c) mit Malon-, Methylmalon- bzw. Ethylmalonsäure dargestellt.

     

The formation of cation-ligand complexes of tributylammonium cation with diethyl carbonate,ethylene carbonate,propylene carbonate, 4-butyrolactone,ethyl acetate,and cyclopentanone ino-dichlorobenzene at 25°C

The effects of adding millimolar quantities of a series of compounds containing the carbonyl function on the conductances of solutions (0.2 mM) of tri-n-butylammonium picrate ino-dichlorobenzene solvent at 25°C have been measured. Values of the complex formation constants K ₁ ⁺ for 1:1 cation-ligand complexes are derived from these data. The corresponding values of –G ₁ ⁰ at 25°C are (in kcal-mole ^–1 ): 4-butyrolactone, 4.29; propylene carbonate, 3.87; ethylene carbonate, 3.59; cyclopentanone, 3.42; ethyl acetate, 2.84; and diethyl carbonate, 2.78. These results together with earlier results from this laboratory are discussed in terms of the effects of structure on cation-ligand affinity.     

1－N－（苯并咪唑－1－乙酰基）－4－苯基－3－氨基硫脲金属配合物的合成及结构表征

合成了新配体１－Ｎ－（苯并咪唑－１－乙酰基）－４－苯基－３－氨基硫脲（ＢＰＭＳ），将其与Ｍｎ（Ⅱ）、Ｃｏ（Ⅱ）、Ｎｉ（Ⅱ）、Ｃｕ（Ⅱ）、Ｃｄ（Ⅱ）、Ｚｎ（Ⅱ）、ＵＯ２（Ⅱ）等金属的醋酸盐反应，合成了７个新配合物。所有化合物均经元素分析、ＩＲ、１ＨＮＭＲ和热重分析等表征。红外光谱表明，配体以四齿方式通过烯醇式羰基氧原子、烯醇式硫羰基硫原子以及Ｃ＝Ｎ１和Ｃ＝Ｎ２的氮原子与金属配位     

四甲氧基取代的二苯并并四苯(DBN)的合成, 晶体结构及聚集效应

本文从商品化的间溴苯甲醚和对甲氧基苯甲醛出发，通过傅-克酰基化反应、串联的羟醛缩合及1,4-迈克尔加成反应，得到三芳基取代的1,5-二酮，然后用查尔酮（Chalcone）作氧化剂，二酮与BF₃.Et₂O 反应形成吡喃鎓盐，再与苯基乙酸钠盐缩合得到芳香二溴代衍生物，产物的DMA溶液在DBU和钯催化剂的作用下，160°C 加热12 h进行脱卤化氢环化反应, 生成四甲氧基取代的二苯并并四苯（DBN）类衍生物。并报道了产物的晶体结构和在溶液中的聚集效应。     

稀土与含硫有机配体配合物的研究 Ⅳ.轻稀土元素与3-苯基-5-(呋喃-2)吡唑啉二硫代甲酸固体配合物的合成及性质

吡唑啉类化合物具有杀菌特性和植物生长调节作用,3-苯基-5-(呋喃-2)吡唑啉二硫代甲酸盐能与许多过渡金属离子形成稳定的配合物。而与稀土的配合物尚未报道。为考察稀土与含硫有机配体形成配合物的条件及该配合物的性质,我们在非水体系和保护气氛     

Antibacterial activities of polystyrene-block-poly(4-vinyl pyridine) and poly(styrene-random-4-vinyl pyridine)

Styrene was polymerized in the presence of benzoyl peroxide (BPO) and 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) to yield polystyrene-TEMPO (PS-TEMPO) macroinitiator. The PS-TEMPO macroinitiator with different molecular weight was reacted with 4-vinyl pyridine (4-VP) to synthesize polystyrene-block-poly(4-vinyl pyridine) (PS-b-PVP), which was then quaternized with n-octyl iodide. Antibacterial activity of the quaternized copolymers was assessed against a gram negative bacterium (Pseudomonas aeruginosa) and a gram positive one (Staphylococcus aureus) by using the shake flask test method, and the results were compared with those of poly(styrene-random-4-vinyl pyridine) (P(ST-r--VP)). The quaternized copolymers inhibited greatly the growth of the bacteria, and PS-b-PVP was more active than P(ST-r-VP), which was ascribed to the fact that the content of quaternized 4-VP units on the surface of the particles of the former copolymer was higher than that corresponding to the latter one.     

Synthesis and Antibacterial Activities of 4-Amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-Amino-5-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles and Their Derivatives

ＩｎｔｒｏｄｕｃｔｉｏｎＳｃｈｉｆｆｂａｓｅｓ ,ａｍｉｄｅｓ ,ｉｍｉｄａｚｏｌｏ[2 ,1 ｂ] 1,3,4 ｔｈｉａｄｉａｚｏｌｅｓ,ａｎｄ 7Ｈ ｓ ｔｒｉａｚｏｌｏ[3,4 ｂ] 1,3,4 ｔｈｉａｄｉ ａｚｉｎｅｓｃｏｎｔａｉｎｉｎｇｈｅｔｅｒｏｃｙｃｌｅｓｈａｖｅｂｅｅｎａｔｔｒａｃｔｉｎｇｍｕｃｈａｔｔｅｎｔｉｏｎａｓｐｏｔｅｎｔｉａｌａｎｔｉｆｕｎｇａｌａｇｅｎｔｓ .1 51,2 ,3 ｔｒｉａ ｚｏｌｅ ,6 7ｍｅｒｃａｐｔｏ 1,2 ,4 ｔｒｉａｚｏｌｅ ,81,3,4 ｔｈｉａｄｉａｚｏｌｅ9 10ａｎｄｔｈｅｉｒｒｅｌａｔｅｄｃｏ…     

ab Initio Calculation on Tautomerism of Pyrazolin—5—ones

ａｂＩｎｉｔｉｏＣａｌｃｕｌａｔｉｏｎｏｎＴａｕｔｏｍｅｒｉｓｍｏｆＰｙｒａｚｏｌｉｎ－５－ｏｎｅｓ￥ＳｕｎＲｅｎ－Ａｎ；ＷａｎｇＣｈａｎｇ－Ｓｈｅｎｇ；ＹａｎｇＺｈｏｎｇ－Ｚｈｉ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＬｉａｏｎｉｎｇＮｏｒｍ...     

4-Hydroxy-2-quinolones 113. Synthesis and antitubercular activity of N-R-amides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid

A preparative method has been developed and the synthesis has been effected of anilides and heterylamides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid. A comparative analysis has been carried out of the structure and antitubercular properties of the synthesized compounds and their analogs unsubstituted in the quinoline nucleus. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 405–414, March, 2007.