具有生物活性的植物内生真菌次生代谢产物

植物内生真菌是指那些在其生活史中的某一段时期生活在植物组织内,对植物组织没有引起明显病害症状的真菌.植物内生真菌几乎在所有植物中存在,它们种类繁多,分布广泛,在长期的自然选择下与寄主植物形成和谐的共生关系,使其产生的次生代谢产物十分丰富,这对农业、医药行业等的发展都具有着巨大的潜在价值.本文对近年来从65种植物中分离获...     

对亚甲基苯醌的不对称催化1,6-共轭加成/芳构化反应

对亚甲基苯醌(para-Quinone Methides,p-QMs)是有机化学中一类结构独特的重要醌类衍生物,其结构单元广泛存在于自然界多类天然产物中,如真菌代谢物、萜烯、植物色素等.此外,对亚甲基苯醌还是许多生物合成、药物代谢过程中的关键活性中间体.在有机化学中,关于对亚甲基苯醌的文献报道最早可以追溯至20世纪初,但在过去的一个多世纪中,其反应研究大多仅局限于一些非手性的转化报道,鲜有基于不对称催化的加成反应研究.最近,兰州大学功能有机分子化学国家重点实验室樊春安研究小组基于不对称相转移催化过程,成功实现了一类新颖     

南海红树林内源真菌#2240的3个蒽醌类次级代谢产物的鉴别和药理活性

红树林内源真菌;蒽醌;次级代谢产物;DNA拓扑异构酶;抑制活性     

Stereoselective Syntheses and Biological Properties of （E）-α- （Methoxyimino） -2-[1-（aryloxy） methyl] -benzeneacetates

IntroductionStrobilurins have been an important class of agri-cultural fungicides,and this class of fungicides is basedon a group of naturally leading derivatives of(E)-meth-ylβ-methoxyacrylate,such as strobilurin A,oudeman-sin A,and myxothiazol A[1,2].T…     

Metabolites of Marine Fungus Aspergillus sp. Collected from Soft Coral Sarcophyton tortuosum

Fungus Aspergillus sp., which was isolated from soft coral Sarcophyton tortuosum, was cultured in the GPY medium containing glucose 10 g/L, peptone 5 g/L, yeast extract 2 g/L, sea water 1 L, at pH=7.5. Four com- pounds, 3,6-diisobutyl-2(1H)-pyrazinone(1), 3-isobutyl-6-(1-hydroxy-2-methylpropyl)-2(1H)-pyrazinone(2), 3-meth- oxy-4-methyl-2,4-dien-pentanoic acid(3) and penicillic acid(4) were obtained from the AcOEt extract of the culture broth. Their structures were elucidated mainly based on the NMR, HR-EI-MS and X-ray single crystal diffraction experimental data. Compound 3 is a new compound. Compound 1 was previously proposed to be the tautomer of flavacol(3,6-diisobutylpyrazin-2-ol, 5). However, the evaluation of the NMR and X-ray single crystal diffraction experimental data permitted us to propose that compound 1 existed as amide form instead of tautomers. Compound 1 is stable both in solution and crystal due to strong intermolecular hydrogen bonds. Incidentally supplying anthracenone to the GPY medium with a dose of 100 mg/L, the yield of penicillic acid(4) in the culture broth of the strain Aspergillus sp. was increased dramatically from 6 mg/L to 57 mg/L.     

Syntheses, Structure and Biological Activities of 2-（ 1H-Benzo [ 1,2,3 ] triazole-l-yl） -1-（3-methyl-4-bromobiphenyl） - 2- （ 1H-1, 2,4-triazole-1 -yl ） ethanone

Introduction 1,2,4-Triazole derivatives represent an interesting class of heterocyclic compounds[1] and have become the most rapidly expanding group of antifungal compoundswith the advantages of toxicity, high oral bioavailability, and broad spectrum of activity against several fungi, including most yeasts and folanentous fungi[2-4].     

具有杀菌活性的2-乙氧羰基-4-芳基-1,5-苯并硫氮杂卓的初步构效关系

以2-乙氧羰基取代的1,5-苯并硫氮杂卓A1和A2为模型化合物,合成了3个系列34个1,5-苯并硫氮杂卓衍生物11~17,考察了它们对新生隐球菌的抑菌活性及杂卓A1和A2的构效关系.研究结果表明,杂卓A1和A2分子中2-位的乙酯基与七元杂环直接相连对其抗真菌活性是必要的.     

New ent-Isopimarane Diterpene from Mangrove Excoecaria agallocha L.

A new ent-isopimarane diterpenoid,Agallochaone A(1),together with the known 8,13-epoxy-14-labden-3-one(2)and Excoecarin B(3)were isolated from the whole plant of mangrove Excoecaria agallocha L.and identified on the basis of a detailed spectral analysis,including 2D NMR spectrometry and HRESI-MS.     

生物降解芳香硝基化合物研究进展

大量人工合成的芳香硝基化合物广泛应用于燃料、染料、精细化工中间体、农药和军事等领域,由于其水溶性差、毒性大而对环境造成了严重污染。自然界中许多微生物具有降解这些化合物的功能。本文总结了近年来有关微生物降解芳香硝基化合物的进展情况及其在环境治理中的应用。     

Synthesis and Fungicidal Activities of Pyrimethanil Heterocyclic Acid Salt

Seven pyrimethanil salts were synthesized by organic base containing nitrogen atom reacting with substituted pyridine acids. They are reported for the first time. Their structures have been confirmed by IR, ^1H NMR and elemental analysis. The preliminary toxicity tests indicated that most of them exhibited excellent fungicidal activities. The relationship between the structures and the fungicidal activities of the compounds was discussed.