纤维素衍生物手性固定相研究进展

本文从用作手性固定相的纤维素衍生物种类、纤维素衍生物手性固定相制备方法及其在高效液相色谱中的应用三个方面介绍了国内外近年来的研究进展, 并展望了该领域今后的研究方向.     

新型小檗碱衍生物的合成及其体外降糖活性

为提高小檗碱的水溶性以及降糖活性，对其C-9位进行了结构修饰，合成了6个9-O-小檗碱酯类衍生物（3a~3f），其中3b~3d和3f为新化合物，其结构经¹H NMR， IR和HR-MS(ESI)表征。选用人肝癌细胞（HepG2）建立胰岛素抵抗模型（HepG2-IR），通过MTT法研究了3a~3f的体外降糖活性。结果表明：3a~3f均具有不同程度的降糖活性，其中化合物3a(IC₅₀=0.044 ±0.97 mg·L^-1)在低浓度0.08 mg·L^-1时，对HepG2-IR细胞葡萄糖消耗量为3.5 mM，优于小檗碱(2.75 mM)。     

高岭石无定形化的动力学研究

Amorphous kaolinite derivatives were prepared through mixing kaolinite with HCOOK and KOH solution. Ki-netics of kaolinite being turned into amorphous derivatvies was investigated by XRD. It showed that the transfor-mation included dynamic and diffuse controlling stages. And the active energy E₁=26.8kJ·mol^-1; E₂=12.2 kJ·mol^-1. TEM and SEM images showed that particle size of the amorphous derivatives was about 50nm. And the amorphous derivatives seemed like alumnsilicate gel， accompanied by some aggregates.     

阴阳离子型表面活性剂双水相萃取色氨酸衍生物和牛血清白蛋白

溴化十二烷基三乙胺（Ｃ１２ＮＥ）和十二烷基硫酸钠（ＳＤＳ）在一定条件下混合可以形成具有清晰界面的两个水相，称为阴阳离子型表面活性剂双水相。作者研究了利用该双水相萃取３种色氨酸衍生物和牛血清白蛋白的可能性．文中采用工作曲线校正扣除表面活性剂背景的影响，萃取结果准确可信。     

A New β-Carboline Alkaloid and a New Derivate of Isoferulic Acid from Anemone altaica

A new β-carboline alkaloid, 4-（9H-β-carbolin-1-yl）-4-oxobutyric acid and a new derivate of isoferulic acid, （E）-3-（3-hydroxy-4-methoxyphenyl）acrylic acid carboxymethyl ester, were isolated from the roots of Anemone altaica. Their structures were determined on the basis of spectral data.     

四羧基金属酞菁负载纤维素纤维的制备及其消臭性能研究

合成了四羧基铁酞菁(Fe-CPc)和四羧基钴酞菁(Co-CPc),并对其进行了元素分析和红外光谱表征.在酸性条件下,将四羧基金属酞菁负载到改性纤维素纤维上,制备得到消臭纤维.实验结果表明,在室温条件下,四羧基铁酞菁消臭纤维(FePcF)、四羧基钴酞菁消臭纤维(CoPcF)和混合金属酞菁消臭纤维(CoFePcF)3种功能性纤维都能有效去除甲硫醇、硫化氢、氨气和三甲胺,甲硫醇和硫化氢按催化氧化机理除去,而氨气和三甲胺按酸碱中和机理除去;3种消臭纤维对甲硫醇和硫化氢的消臭效果为CoFePcF>CoPcF>FePcF.     

Theoretical Study on the Structures and Electronic Spectra of the Derivatives of C_(60)-P-2,4,6-Triphenyl Borazinc

1 INTRODUCTION The electron-transfer reaction of C60 derivatives, especially light-induced electron-transfer reaction, has been an active research field for a long time. Many researches are focused on the long-live charge- separated state caused by electron-transfer[1]. And several electron-transfers between electron donor and C60 or intramolecular electron-transfer have been confirmed. As an example, TTF-C60 is proved to be a short-live charge-separated compound[2].Due to the excelle…     

吖啶类衍生物的荧光性质

用比较法测得23种啶类衍生物的荧光量子效率（Φf)，以评估这些化合物的荧光性质，结果表明，N－烃基吖啶酮类化合物的荧光量子效率要比9－取代苯基吖啶类和9－取代苯亚甲基－10－甲基－9，10－二氢吖啶类化合物的荧光量子效率大，在非极性溶剂中，9－聚代苯亚甲基－9，10二氢吖啶分子内的强吸电子基NO2增强荧光量子效率，强推电子基OCH3降低荧光量子效率，这些测量结果与取代基的电子作用经验规律不相符，这种现象可以用分子内电荷转移理论进行解释。     

胶束电动毛细管色谱半导体激光诱导荧光测定单胺类神经递质

建立了用半导体激光诱导荧光结合胶束电动毛细管色谱测定单胺类神经递质——去甲肾上腺素和多巴胺的高灵敏分析方法。考察了青色素衍生物 ( Cy5 )对去甲肾上腺素和多巴胺的衍生条件。在优化条件下 ,去甲肾上腺素和多巴胺在 3× 1 0 - 8～ 5× 1 0 - 6 mol/L浓度范围内与荧光强度呈良好的线性关系。去甲肾上腺素和多巴胺的检出限分别为 5 .9× 1 0 - 9、 5 .4× 1 0 - 9mol/L。方法简便、灵敏、样品用量少 ,可用于痕量单胺类神经递质分析