新一代安眠药"忆梦返"的性质及检测

本文介绍了第三代安眠药亿梦返的化学结构和相关的药理性质，应用高效液相色谱和气-质联用方法定性和定量地分析了“亿梦返”的主要成分——佐匹克隆，并初步探讨其在人体内的致死量。     

用多克隆抗体构建的夹心免疫传感器检测心肌肌钙蛋白I

用表面等离子体子共振生物传感器构建对心肌肌钙蛋白I特异性的免疫传感器检测心肌肌钙蛋白I,并建立两种检测方法:直接法的最低检测限为2.5μg/L,基于传感膜上的夹心免疫法的灵敏度为0.5μg/L,检测范围为0.5～20μg/L,批内及批间精密度分别为3.5%～4.9%,6.1%～7.4%;用夹心法及国外试剂盒对40名健康献血者和20例急性心肌梗死患者血清心肌肌钙蛋白I水平进行检测,两者符合率为95%.     

Scheme for Implementation of Ancillary-Free 1→3 Optimal Phase-Covariant Quantum Cloning with Trapped Ions

We propose a simple scheme for the implementation of the ancillary-free 1→3 optimal phase-covariant quantum cloning for x-y equatorial qubits in ion-trap system. In the scheme, the vibrational mode is only virtually excited, which is very important in view of decoherence. The present proposal can be realized based on current available technologies.     

腔QED中相位协变量子克隆机的实现及纠错

应用N个二能级原子和单模真空腔场相互作用,提出了一个1→2的相位协变量子克隆机的方案.同时,基于这种克隆机,我们也提出了量子纠错方案,考虑了由相位和比特反转错误所产生的消相干影响,通过对后两个比特位进行Bell测量,并沿着合适的轴旋转第一比特,就可以恢复初始态.     

正链RNA病毒基因组感染性克隆研究进展

综合叙述了构建正链RNA病毒基因组全长感染性cDNA克隆的基本思路和关键技术，并总结了影响基因且全长克隆感染性的因素，还简要介绍了利用正链RNA病毒基因组感染性克隆所得的一些研究进展，概括了目前内在该方面的研究现状。     

基于克隆选择的混合遗传算法在碳纳米管结构优化中的研究

针对分子动力学模拟中碳纳米管的结构优化问题，提出了一种新的优化算法.新的优化算法在遗传算法的基础上，引入了克隆选择机理和模拟退火技术.对五个典型函数的优化测试结果表明，该算法搜索过程稳定性好，可较好地实现全局最优.将其应用于碳纳米管原子结构优化，加快了能量优化速度，提高了优化质量.模拟结果说明，混合遗传算法的优化时间随原子数增加而呈线性增长.在碳纳米管原子数较多时，结构优化时间比共轭梯度法降低一个数量级左右，大大降低了系统的模拟时间. 关键词： 分子动力学 碳纳米管 能量优化 遗传算法 克隆选择算法     

Functional Mechanism of Resveratrol in Inhabiting Growth of Cells Is174t and Its Mechanism in Subcutaneously Transplanted Tumor of Nude Mice

To explore the functional mechanism of Resveratrol against colon cancer cells ls174t and the growth of colon cancer tissue of tumor-bearing mice, MTT method was used to observe the functions of resveratrol for inhibition against cells ls174t in vitro. Transmission electron microscope was used to observe the cell apoptosis. FCM assay was performed to measure the change of the cell apoptosis rate and of cell cycle. RT-PCR method was used to detect the expressions of bcl-2 and bax mRNA. Western blot method was used to detect the expressions of bcl-2 and bax protein. Ceils ls174t were transplanted subcutaneously to nude mice to observe the effect of resveratrol on the growth of subcutaneously transplanted tumor, RT-PCR method was used to detect the expressions of bcl-2 and bax mRNA in the tumor tissue. Western blot method was used to detect the expressions of bcl-2 and bax protein in the tumor tissue. Resveratrol has an effect of inhibiting proliferation of cells ls174t in vitro（P〈0.01）. It is able to induce the apoptosis of cells ls174t, causing the decrease in the expression of bcl-2 and the increase in the expression of bax. Resveratrol could inhibit the growth of subcutaneously transplanted tumor of nude mice（P〈0.05）, causing the decrease in the expression of bcl-2 and the increase in the expression of bax. Resveratrol can inhibit the growth of cells 174t and the growth of subcutaneously transplanted tumor. The mechanism is possibly related to the induction of the cell apoptosis and the regulation of bcl-2/bax expression.     

Deterministic assisted clone of an unknown four-particle entangled cluster-type state

Two deterministic schemes are proposed to realize the assisted clone of an unknown four-particle entangled cluster- type state. The schemes include two stages. The first stage requires teleportation via maximal entanglement as the quantum channel. In the second stages of the protocols, two novel sets of mutually orthogonal basis vectors are constructed, With the assistance of the preparer through a four-particle or two-step two-particle projective measurement under these bases, the perfect copy of an original state can be produced. Comparing with the previous protocols which produce the unknown state and its orthogonal complement state at the site of the sender, the proposed schemes generate the unknown state deterministically.     

凝胶渗透色谱结合气相色谱-负化学源质谱法分析鱼肉及鱼油中的多溴联苯醚和得克隆阻燃剂

建立了凝胶渗透色谱(GPC)结合气相色谱-负化学源质谱(GC-NCI/MS)检测鱼肉及鱼油中8种多溴联苯醚(PBDEs)同系物及2种得克隆阻燃剂(DP)的分析方法。试样中加入内标物BDE-77和13C12-BDE-209后进行索氏提取,提取液经自动GPC系统除脂,多层硅胶层析柱净化后,在15 m长的毛细管气相色谱柱上分离,NCI/MS以选择离子监测方式检测目标化合物。以鱼肉样品为基质,当PBDEs的加标水平为0.2 ng/g和2 ng/g、BDE-209和DP的加标水平相应提高10倍时,其平均加标回收率为71.1%～121.4%,相对标准偏差为2.96%～13.31%(n=5);以信噪比(S/N)为3计算方法的检出限(LOD)为2.2～39.8 ng/kg。用该方法检测市售鱼肉及鱼油样品,其中多溴联苯醚总含量为2.18～15.93 ng/g,以BDE-209、BDE-47为主,两种DP均未检出。该方法准确、灵敏度高,能够满足富含脂质的动物性样品中痕量DP和PBDEs残留的分析要求。     

基于原子系综四波混频过程的量子信息协议

与经典体系相比,量子信息协议在大幅提高信息处理的安全性、保真度和容量方面具有巨大的优势。各种具有不同功能的量子信息协议已经被提出并实现。介绍了利用铷原子四波混频过程构建一套能兼容多种不同量子信息协议的多功能平台。基于这个平台可以实现并行9通道全光量子隐形传态,部分无实体量子态传输和最优N→M相干态量子克隆协议。更重要的是,部分无实体量子态传输协议可以同时连接全光量子隐形传态协议和最优1→M相干态量子克隆协议。这些量子信息协议在全光量子通信中具有潜在的应用。