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971.
A. L. Vlasyuk G. D. Gamalevich A. V. Ignatenko E. P. Serebryakov M. I. Struchkova 《Russian Chemical Bulletin》2004,53(3):693-702
Acetylation of (±)-1-phenylnon-2-yn-1-ol, (±)-1-phenylhept-1-yn-3-ol, and (±)-1-phenylundec-4-yn-3-ol ((±)-5) in the presence of lipase from Candida cylindracea (CCL) proceeds slowly to give products with ee 20%. The acetates of these alcohols are hydrolyzed in the presence of porcine pancreatic lipase (PPL) equally unsatisfactorily. The (6-arene)tricarbonylchromium complex of alcohol (±)-5 is acetylated in the presence of CCL up to 22% conversion to give (R)-acetate whose oxidative decomplexation followed by saponification results in alcohol (R)-(–)-5 with ee 95%. The configuration of alcohols (–)-5 and (+)-5 was determined by NMR spectroscopy of their esters with (R)- and (S)-Mosher"s acids. 相似文献
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974.
Long-duration experiments with clouds of microparticles are planned for the ICAPS facility on board the International Space Station ISS. The scientific objectives of such experiments are widespread and are ranging from the simulation of aerosol behaviour in Earths atmosphere to the formation of planets in the early solar system. It is, however, even under microgravity conditions, impossible to sustain a cloud of free-floating, microscopic particles for an extended period of time, due to thermal diffusion and due to unavoidable external accelerations. Therefore, a trap for dust clouds is required which prevents the diffusion of the particles, which provides a source of relative velocities between the dust grains and which can also concentrate the dust to higher number densities that are otherwise not achievable. We are planning to use the photophoretic effect for such a particle trap. First short-duration microgravity experiments on the photophoretic motion of microscopic particles show that such an optical particle-cloud trap is feasible. First tests of a two-dimensional trap were performed in the Bremen drop tower. 相似文献
975.
M.?B.?BarbaroEmail author R.?Cenni A.?Molinari M.?R.?Quaglia 《The European Physical Journal A - Hadrons and Nuclei》2004,22(3):377-390
We address the problem of two pairs of fermions living on an arbitrary number of single-particle levels of a potential well (mean field) and interacting through a pairing force in the framework of the Richardson equations. The associated solutions are classified in terms of a number vl, which reduces to the seniority v in the limit of a large pairing strength G and yields the number of pairs not developing a collective behaviour, their energy remaining finite in the G limit. We express analytically, through the moments of the single-particle levels distribution, the collective mode energy and the two critical values Gcr+ and Gcr- of the coupling which can exist on a single-particle level with no pair degeneracy. Notably Gcr+ and Gcr-, when the number of single particle levels goes to infinity, merge into the critical coupling of a one-pair system Gcr (when it exists), which is not envisioned by the Richardson theory. In correspondence of Gcr, the system undergoes a transition from a mean-field- to a pairing-dominated regime. We finally explore the behaviour of the excitation energies, wave functions and pair transfer amplitudes versus G finding out that the former, for G > Gcr-, come close to the BCS predictions, whereas the latter display a divergence at Gcr, signaling the onset of a long-range off-diagonal order in the system. 相似文献
976.
Three epitopes of human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) recognised by neutralising and non-neutralising monoclonal antibodies (mAbs) were characterised using competitive binding assays, dissociation constant measurements with glycosylated and non-glycosylated rhGM-CSF, bioactivity inhibition studies, and synthetic peptide arrays. Based on the first approach, two different binding sites were identified: an area referred to as A, recognised by mAbs M1B8 and CC5B5, and an area referred to as B, recognised by mAbs CC1H7 and CC3C12. These binding sites on hGM-CSF were accurately delineated using cytokine-derived overlapping peptide scans and combinatorial hexapeptide libraries prepared by SPOT synthesis on cellulose membranes. We assigned the identical linear epitope A1P2A3R4 to both non-neutralising mAbs CC1H7 and CC3C12. The conformational epitopes A18E21R23R24F119 and R23E21N17W13 recognised by mAb CC5B5, and P118F119EW13E14 recognised by mAb M1B8, were delineated by dual-positional scanning and subsequent iterative searches with two interrogating positions. Competitive binding assays with mAbs M1B8 and CC5B5 revealed the overlapping nature of the cytokine recognition. However, peptide library screening confirmed their binding to different epitopes of which the essential amino acids were found very closely located on the native protein surface. Inhibition of hGM-CSF biological activity by these mAbs demonstrated that these epitopes are located within or very near the receptor binding site of hGM-CSF. Finally, this work supports the importance of residues from helix A and residues from the C-terminal region of the cytokine, composing a common area that is indispensable for the cytokine's biological activity. 相似文献
977.
F. C. Camargo A. F. Lehner J. D. Harkins C. G. Hughes W. Karpiesiuk J. Boyles W. E. Woods T. Tobin 《Chromatographia》2004,60(7-8):371-378
Trimetoquinol (TMQ) (1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, m.w. 345) is the prototype tetrahydroisoquinoline pharmaceutical. TMQ is marketed as a bronchodilator in human medicine; in horse racing, TMQ is listed as an Association of Racing Commissioners International (ARCI) class 3 foreign substance. As such, TMQ is considered to have the potential to affect racing performance in horses, and a validated qualitative confirmatory method is required to regulate its use in racing. We selected 8 g kg–1 of TMQ IV as a safe and effective dose for studies on its metabolism and analytical detection in horses. We developed a solid phase extraction method for recovery of TMQ and its metabolites from equine urine, identified suitable high performance liquid chromatographic conditions for these substances and our internal standard, papaverine, and developed a highly sensitive ESI(+)-LC-MS-MS method (estimated LOD, 100 pg mL–1) for TMQ and its major metabolites in equine urine. Multiple Reaction Monitoring (MRM) analysis of unhydrolyzed post-administration urine showed small amounts of unchanged TMQ, along with glucuronide, methylated, and sulfated metabolites, with glucuronide metabolites predominating. Following glucuronidase hydrolysis, recovered parent TMQ peaked at relatively high concentrations (>300 ng mL–1) within 1 h of administration and thereafter declined. The methylated metabolites of TMQ peaked later and at comparable total concentrations, and thereafter declined more slowly. These data suggest that glucuronide hydrolysis of post-administration urine samples will allow recovery of readily identifiable quantities of parent TMQ. These findings, combined with the highly sensitive LC-MS-MS detection of parent TMQ described herein suggest that glucuronide hydrolysis of post-administration urine, followed by LC-MS-MS or other analysis, will allow effective regulatory control of this agent in racing horses.Published as # 351 from the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. Published as Kentucky Agricultural Experiment Station Article # 04-14-048 with the approval of the Dean and Director, College of Agriculture and the Kentucky Agricultural Experimental Station.Revised: 8 June and 12 July 2004 相似文献
978.
L. A. Nazarov L. A. Nazarova V. M. Fomin N. P. Ryashentsev A. N. Ryashentsev A. V. Solov'ev 《Journal of Applied Mechanics and Technical Physics》2004,45(5):692-698
A mathematical model for the mechanism of increasing oil output of productive seams is developed. The model involves a deliberate conversion of segments of the fault zone of the country rock to a supercritical state, which leads to a local redistribution of stresses in the block massif of rocks and an increase in contour and seam pressures. Based on solving the problem of restricted filtration, it is shown that the use of the proposed mechanism can ensure a relative increase in well production of 5–8%. 相似文献
979.
980.
Stuart?ClaryEmail author Jacek?FabrykowskiEmail author 《Czechoslovak Mathematical Journal》2004,54(4):915-927
In this paper we establish the distribution of prime numbers in a given arithmetic progression p l for which ap + b is squarefree. 相似文献