5-氨基-1,3-二氢-1,3-二氧-异吲哚-2-丙酸类衍生物的合成及抗血管生成活性研究

根据RGD序列肽的构效关系, 设计并合成了一系列以5-氨基-1,3-二氢-1,3-二氧-异吲哚-2-丙酸为分子骨架的新化合物. 其中间体和目标物的化学结构经¹H NMR, MS和元素分析确证. 体外初步生物活性筛选结果表明, 目标物在10^－5 mol/L浓度下对bFGF诱导的鸡胚绒毛尿囊膜新生血管生成有显著抑制活性.     

表面包覆改性对纳米CeO2分散性的影响

了改善纳米CeO2在Zn-Al类共晶合金中的分散性,采用超声液相包覆法对纳米CeO2进行表面活性剂表面包覆改性,并用AES测定了包覆层的厚度,用TEM研究了CeO2的团聚状况,用TGA分析了有机物包覆层的炭化温度范围,最后用FE-SEM观察了CeO2在复合材料中的分散情况。结果表明,包覆在纳米CeO2表面的厚度约为20 nm的表面活性剂层提高了微粒的分散性,而且该包覆层在495℃时已经炭化。热力学计算的结果也表明,炭化层能与氧化膜反应,该反应提高了CeO2与基体间的润湿性,并使其均匀分布在基体合金中。     

KF－Al2O3催化下3，4－二氢－2H－吡喃[3,2-h]喹啉衍生物的合成

芳醛、8－羟基喹啉与丙二腈或氰乙酸乙酯KF－Al2O3催化下反应生成一系列新 的3，4－二氢－2H－吡喃[3,2-h]喹淋衍生物，产物的结构通过单晶X射线确证。     

苯并咪唑衍生物的合成改进

利用空气作氧化剂, 无需任何催化剂, 以甲醇作溶剂, 芳香醛与邻苯二胺反应一步合成苯并咪唑衍生物, 产率均超过69%, 产物的结构通过元素分析、红外光谱和核磁共振氢谱确证, 该方法具有操作简单、反应条件温和、环境友好的优点.     

Protein-coated β-ferric hydrous oxide particles: An electrokinetic and electrooptic study

Using microelectrophoresis and electric light scattering techniques, we investigated the adsorption characteristics, surface coverage and surface electric parameters of superstructures from two isoforms of plastocyanin, PCa and PCb, in an oxidized state adsorbed on β-ferric hydrous oxide particles. The surface electric charge and electric dipole moments of the composite particles and the thickness of the protein adsorption layer are determined in a wide pH range, at different ionic strengths and concentration ratios of PC to β-FeOOH. The adsorption of the two proteins was found to shift the particles’ isoelectric point and to alter the total electric charge and the electric dipole moments of the oxide particles to different extent. A “reversal” in the direction of the permanent dipole moment is observed at lower pH for PCb- than for PCa-coated oxide particles. Strict correlation is found between the changes in the electrokinetic charge of the composite particles and the variation in their “permanent” dipole moments. Data suggest that the adsorption of the proteins is driven by electrostatic and/or hydrophobic interactions with the oxide surfaces dependent on pH. The adsorption behaviour is consistent with the involvement of the “eastern” and “northern” patches of the plastocyanin molecules in their adsorption on the oxide surfaces that are differently charged depending on pH.     

机械球磨与反应烧结合成Sr2CeO4发光体的研究

Sr₂CeO₄ phosphor was synthesized by mechanical milling and reactive sintering in this work. The solid state reaction of SrCO₃and CeO₂ (2∶1) started at about 850 ℃ and completed at 1 000 ℃ for about 4 h. Two types of formation mechanism of Sr₂CeO₄ were proposed. When the starting powder mixture was fired above 1 000 ℃, the unstable intermediate phase SrCeO₃was developed, which then reacted with SrCO₃to form the final product Sr₂CeO₄, however, SrCO₃and CeO₂ converted directly to Sr₂CeO₄ at a lower temperature. The XRD results showed the crystal structure of Sr₂CeO₄ was orthorhombic. The emission spectra displayed a broad band with maximum at about 465 nm. The mechanical milling of starting power mixture and the sintering temperature had no effect on this emission spectra.     

铒离子及其阳离子卟啉配合物对金黄色葡萄球菌生长的抑制和刺激作用

用微量热法研究了Er³⁺、TMP{TMP=5，10，15，20-四(4-甲氧基苯基)卟啉}及其阳离子铒卟啉配合物[Er(TMP)(H₂O)₃]Cl对金黄色葡萄球菌生长作用的生物热动力学特征，求算了在Er³⁺、TMP和[Er(TMP)(H₂O)₃]Cl作用下，金黄色葡萄球菌生长的热动力学参数。实验结果表明：TMP对金黄色葡萄球菌生长的作用表现为单向的抑制作用，而Er³⁺和[Er(TMP)(H₂O)₃]Cl对金黄色葡萄球菌的生长有双向调节作用。在低浓度下，Er³⁺对金黄色葡萄球菌生长的刺激作用强于[Er(TMP)(H₂O)₃]Cl；在较高浓度下，[Er(TMP)(H₂O)₃]Cl对金黄色葡萄球菌生长的抑制作用显著强于Er³⁺。对金黄色葡萄球菌的抗菌活性为：[Er(TMP)(H₂O)₃]Cl>>TMP>Er³⁺。对相互作用机理做了初步探讨。     

电子俘获材料Zn_4B_6O_(13)∶Dy~(3+)的热释光特性研究

通过高温固相扩散反应合成了稀土元素镝掺杂的 Zn4 - x B6 O1 3∶ x Dy3+ 磷光体 .测定了该化合物在高能6 0 Co伽玛射线辐照下的热释发光曲线和三维热释光谱 .三维热释光谱表明 ,位于大约 480 nm和 5 80 nm的发光谱带来自于 Dy3+ 离子的 f-f 跃迁 .基质中掺杂的 Dy3+ 离子浓度的变化能够改变陷阱的相对分布 ,随着Dy3+浓度的增加 ,发光峰温向高温方向移动 ,这可提高剂量器的热稳定性 .当辐照剂量增加时 ,发光峰温亦向高温方向移动 ,即陷阱加深 .确定了 Zn3.86 B6 O1 3∶ 0 .1 6Dy3+样品主峰的陷阱深度 E=0 .73 e V,频率因子S=2 .43× 1 0 9s- 1 .在 1～ 1 0 0 Gy治疗级范围内 ,Zn3.86 B6 O1 3∶ 0 .1 6Dy3+ 对 6 0 Co伽玛射线辐照的热释光剂量响应呈良好的线性关系 .实验结果表明 ,Zn3.86 B6 O1 3∶ 0 .1 6Dy3+是一个潜在的应用于临床医疗的伽玛射线电离辐射热释光剂量计材料 .     

4－（2－氨基噻唑）－间苯二酚为柱前衍化剂液相色谱／电化学检测Fe、Co、Ni

４－（２－氨基噻唑）－间苯二酚为柱前衍化剂液相色谱／电化学检测Ｆｅ、Ｃｏ、Ｎｉ格日勒，李惠梅，李南强，汪尔康（中国科学院长春应用化学研究所电分析化学开放实验室，北京大学化学系，长春，１３００２２）关键词液相色谱，Ｆｅ，Ｃｏ，Ｎｉ，４－（２－氨基噻唑）...