Synthesis and radiopharmacological study of new metallated thiazolidines and dithioacetals of N-allyl-substituted cysteamine and methylcysteamine

New germa- and silathiazolidines or germa- and siladithioacetals with N-allyl-substituted cysteamine and methylcysteamine ligands have been synthesized and their pharmacological properties (toxicity, radioprotective activity) have been studied. A notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new organometallic derivatives compared to N-allyl-substituted cysteamine and methylcysteamine were observed.     

Synthesis and radioprotective study of new siladithioacetals and germadithioacetals

A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2‐[1‐(1‐naphthyl)ethyl]‐2‐imidazoline have been prepared and their radiopharmacological properties (radioprotective activity and toxicity) have been determined in mice. A number of these new organometallic derivatives have been found to possess radioprotective activity. We have also noted a notable decrease of the toxicity and a fairly large increase in the radioprotective activity in comparison with the unsubstituted organic molecules. Copyright © 2003 John Wiley & Sons, Ltd.