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1.
Dmitrenok A. S. Radhika P. Anjaneyulu V. Subrahmanyam C. Subba Rao P. V. Dmitrenok P. S. Boguslavsky V. M. 《Russian Chemical Bulletin》2003,52(8):1868-1872
Sphingolipids and glycolipids including previously unknown (2S,3S,4R)-1,3,4-trihydroxy-2-(2-(R)-hydroxyoctadecanoylamino)octadec-8E-ene, (2S,3R)-1,3-dihydroxy-2-octadecanoylamino-4E,8E-hexadecadiene, and (2-hydroxy-3-hexadecyloxypropyl)--L-fucopyranoside were isolated from soft corals collected on the shelf near the Andaman Islands (Indian Ocean). The structures of all compounds were established by spectroscopic methods and chemical analyses. The lipids possessed antibacterial activity against Bacillus subtilis, Bacillus pumilus, Escherichia coli, and Pseudomonas aeruginosa and antifungal activity against Aspergillus niger, Rhizopus oryzae, and Candida albicans. 相似文献
2.
Zhifang Xi Wei Bie Wei Chen Dong Liu Leen van Ofwegen Peter Proksch Wenhan Lin 《Helvetica chimica acta》2013,96(12):2218-2227
Six new biscembranoids, namely, sarcophytolides G–L ( 1 – 6 , resp.), together with six known analogs, were isolated from a marine soft coral Sarcophyton elegans. The structures of the new compounds were established on the basis of 1D‐ and 2D‐NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analysis together with the aid of MS, CD, and IR data. The unusual isobiscembranoid sarcophytolide G ( 1 ) was found for the first time in the genus Sarcophyton. 相似文献
3.
Chi-Chien Lin Yu-Kang Chang Shih-Chao Lin Jui-Hsin Su Ya-Hsuan Chao Kuo-Tung Tang 《Molecules (Basel, Switzerland)》2021,26(9)
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the production of β2-glycoprotein I (β2GPI)-dependent autoantibodies, with vascular thrombosis or obstetrical complications. Around 20% of APS patients are refractory to current treatments. Crassolide, a cembranoid diterpene extracted from soft corals, is a potential therapeutic candidate. Here, to examine the anti-inflammatory properties of crassolide, we first determined its effects on bone marrow-derived and splenic dendritic cells (DC). Specifically, we applied lipopolysaccharide (LPS) or β2GPI stimulation and measured the expressions of CD80 and CD86, and secretions of cytokines. We also determined in the OT-II mice, if bone marrow-derived DC was able to stimulate antigen-specific T cells. Moreover, we examined the therapeutic potential of crassolide postimmunization in a murine model of APS that depended on active immunization with β2GPI. The vascular manifestations were evaluated in terms of fluorescein-induced thrombi in mesenteric microvessels, whereas the obstetric manifestations were evaluated based on the proportion of fetal loss after pregnancy. We also measured blood titers of anti-β2GPI antibody, splenic cell proliferative responses and cytokine secretions after β2GPI stimulation ex vivo. Finally, we determined in these mice, hematological, hepatic and renal toxicities of crassolide. Crassolide after LPS stimulation suppressed DC maturation and secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-12 and IL-23, and downstream T cell activation. Crassolide could partially ameliorate both the vascular and obstetric manifestations of APS in BALB/c mice. Both blood titers of anti-β2GPI antibody and splenic cell proliferation after β2GPI stimulation were reduced. Splenic Th1 and Th17 responses were also lowered after β2GPI stimulation. Finally, within therapeutic doses of crassolide, we found no evidence of its toxicity. In conclusion, we showed the ability of crassolide to suppress DC and downstream T cell responses. Crassolide is therefore a potential candidate for adjunctive therapy in APS. 相似文献
4.
Four new diterpenes, cespihypotins W–Z ( 1 – 4 ), having the verticillane skeleton and characterized by an α,β‐unsaturated γ‐hydroxycyclopentanone moiety, and a new eudesmanolide‐type sesquiterpene, cespilactam A ( 5 ), containing an α,β‐unsaturated γ‐lactam residue, were isolated from the AcOEt‐soluble fraction of the Taiwanese soft coral Cespitularia hypotentaculata. The structure and relative configuration of these metabolites was elucidated through extensive interpretation of MS, COSY, HSQC, HMBC, and NOESY experiments and by comparison of their NMR data with those of related compounds. 相似文献
5.
Wan-Chi Tsai Wen-Hung Wang Bo-Cian Huang Chiung-Yao Huang Jyh-Horng Sheu 《Molecules (Basel, Switzerland)》2021,26(22)
Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of patients are diagnosed with a metastatic disease, which is associated with a five-year survival rate of only 3%. 5-epi-Sinuleptolide, a norditerpene isolated from Sinularia sp., has been demonstrated to possess cytotoxic activity against cancer cells. However, the cytotoxicity against pancreatic cancer cells and the related mechanisms are unknown. The aim of this study was to evaluate the anti-pancreatic cancer potential of 5-epi-sinuleptolide and to elucidate the underlying mechanisms. The inhibitory effects of 5-epi-sinuleptolide treatment on the proliferation of pancreatic cancer cells were determined and the results showed that 5-epi-sinuleptolide treatment inhibited cell proliferation, induced apoptosis and G2/M cell cycle arrest, and suppressed the invasion of pancreatic cancer cells. The results of western blotting further revealed that 5-epi-sinuleptolide could inhibit JAK2/STAT3, AKT, and ERK phosphorylation, which may account for the diverse cytotoxic effects of 5-epi-sinuleptolide. Taken together, our present investigation unveils a new therapeutic and anti-metastatic potential of 5-epi-sinuleptolide for pancreatic cancer treatment. 相似文献
6.
Liang Li Chang‐Yun Wang Chang‐Lun Shao Yue‐Wei Guo Guo‐Qiang Li Xue‐Ping Sun Lei Han Hui Huang Hua‐Shi Guan 《Helvetica chimica acta》2009,92(8):1495-1502
Chemical examination of the soft coral Sarcophyton infundibuliforme collected from the South China Sea resulted in the isolation of the three new O‐glycosylglycerol derivatives sarcoglycosides A–C ( 1 – 3 ), together with two known compounds, chimyl alcohol ( 4 ) and hexadecanol ( 5 ). Their structures were elucidated by combined spectral and chemical methods. All the compounds showed moderate toxicity to brine shrimps Artemia salina. 相似文献
7.
Kateina Osterrothov Laura Minaíkov Adam Culka Jaroslav Kunto Jan Jehli
ka 《Journal of Raman spectroscopy : JRS》2014,45(9):830-837
A silver Torah shield fitted with a set of precious stones and glass imitations crafted in Poland in the first half of the 19th century was investigated using two of the currently distributed portable and relatively low‐cost Raman spectrometers in situ at the Jewish Museum in Prague. Observed Raman peaks corresponded well (+/− 3 cm−1) to the reference values. The hand‐held instruments operated at 785‐ and 532‐nm laser excitations showed good performance in the fast and unambiguous identification of nearly 60 stones which were fitted on the shield: one blue aquamarine, three purple amethysts, thirteen red garnets (all classified as high‐percentage almandines), three white pearls, fifteen pieces of red coral and five chalcedonies (one white and four red). All of the other stones were identified as colored glass. The rather chaotic mixture of stones of various colors, cuts and sizes and the total volume of imitation glass support the theory that the mounted stones were gathered from Jewish households and donated for the adornment of the shield. The common portable Raman instruments represent an ideal tool for the quick and accurate identification of gemstones mounted in historical artifacts in situ in the framework of museum or collection sites in a non‐destructive way. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
8.
Li‐Gong Yao Hai‐Yan Zhang Lin‐Fu Liang Xian‐Jun Guo Shui‐Chun Mao Yue‐Wei Guo 《Helvetica chimica acta》2012,95(2):235-239
Two new cembranoids, yalongenes A ( 1 ) and B ( 2 ), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller . Their structures were elucidated by detailed spectroscopic analysis (IR, MS, and NMR) and by comparison with a related model compound. Yalongenes 1 and 2 were evaluated for their cytoprotective effects on SH‐SY5Y cell injury induced by H2O2 in vitro, and the result showed that only compound 1 had a significant cytoprotective activity at the concentration of 1 μM . 相似文献
9.
Shean-Yeaw Ng Chin-Soon Phan Takahiro Ishii Takashi Kamada Toshiyuki Hamada Charles Santhanaraju Vairappan 《Molecules (Basel, Switzerland)》2020,25(22)
Members of the marine soft coral genus Xenia are rich in a diversity of diterpenes. A total of 199 terpenes consisting of 14 sesquiterpenes, 180 diterpenes, and 5 steroids have been reported to date. Xenicane diterpenes were reported to be the most common chemical skeleton biosynthesized by members of this genus. Most of the literature reported the chemical diversity of Xenia collected from the coral reefs in the South China Sea and the coastal waters of Taiwan. Although there was a brief review on the terpenoids of Xenia in 2015, the present review is a comprehensive overview of the structural diversity of secondary metabolites isolated from soft coral genus Xenia and their potent biological activity as reported between 1977 to 2019. 相似文献
10.
Ernesto Fattorusso Orazio Taglialatela-Scafati Carlo Irace Giorgio Bavestrello 《Tetrahedron》2009,65(15):2898-3086
Three novel cembrane diterpenoids, decaryiols B-D (5-7), characterized by a bicyclic skeleton of the decaryiol-type, have been isolated from the Indonesian soft coral Lobophytum sp., along with three known cembranoids. The stereostructures of these metabolites have been established through extensive NMR spectroscopic analysis, application of the modified Mosher method, and chemical conversion. Cembranoids obtained from Lobophytum sp. (2-7) and six semisynthetic derivatives (9-14) prepared from decaryiol were tested for cell growth inhibitory activity against three different cell lines. O-Methyl decaryiol (10) exhibited a significant and selective activity against glioma cell lines. 相似文献