Capacitive sensors using electropolymerized o-phenylenediamine film doped with ion-pair complex as selective elements for the determination of pentoxyverine

A capacitive sensing method based on electropolymerized o-phenylenediamine film doped with pentoxyverine ion-pair complex as selective element was successfully developed for the determination of pentoxyverine. Ion-pair complex, pentoxyverine-tetraphenylborate or pentoxyverine-picrolonate, was embedded in electropolymerized o-phenylenediamine film by electropolymerizing technique. The effects of working frequency and test solution pH on the detection of pentoxyverine were investigated in detail and optimized. For the sensor modified with pentoxyverine-tetraphenylborate, calibration curve was linear over the concentration range of 5.0×10⁻⁷ to 1.0×10⁻⁴ M with a detection limit of 1.0×10⁻⁷ M at pH 7. The proposed sensor exhibited high selectivity and sensitivity to pentoxyverine. The results in sample analysis confirmed the usefulness of the proposed ISC sensor for quantitative analysis, and also indicated that this method might find applications in the assay of other drugs.     

枸橼酸维静宁的流动注射化学发光法测定

用过氧化氢和次氯酸钠在碱性介质中协同氧化枸橼酸维静宁产生化学发光,建立了化学发光测定枸橼酸维静宁的新方法。枸橼酸维静宁的浓度在3.0×10-6～3.0×10-4mol/L范围内与化学发光强度呈良好的线性关系,检出限为2.8×10-8mol/L。对1.0×10-5mol/L枸橼酸维静宁进行11次平行测定的相对标准偏差为1.38%。用该法测定了枸橼酸维静宁片剂的含量,结果与药典法测得值一致。     

导数分光光度—阻尼因子矩阵法同时测定三元混合组分

本文提出导数分光光度阻尼因子矩阵法同时测定带有辅料或其它呈一次或二次曲线干扰吸收的多元混合组分的基本原理和实验方法。以同时测定止喘咳糖浆中盐酸苯海拉明,盐酸麻黄碱,咳必清为例,研究了方法的可靠性和测量的适宜条件。结果满意。     

Selective Liquid and (Vinyl-Chloride) Pentoxyverine Membrane Electrodes - Their Preparation and Use for the Potentiometric Determination of Pentoxyverine Citrate

Abstract

The use of liquid and poly(vinyl-chloride) membrane electrodes which are sensitive and reasonably selective for pentoxyverine determination is described here. The electrodes are based on the use of pentoxyverine-picrate, pentoxyverine-picrolonate and pentoxyverine-tetraphenylborate ion association complexes as electroactive materials in nitrobenzene or in poly(vinyl chloride) matrix. These electrodes show near Nernstian response values in different concentration ranges, depending on the nature of the used counter-ions, at 3.3–7.8 pH range. Potentiometric determination of pentoxyverine citrate with use of these electrodes gives good results which later on are compared with those obtained by non-aqueous titration.     

Study on the enhancement of Ru(bpy)3(2+) electrochemiluminescence by nanogold and its application for pentoxyverine detection

In this work, CE separation with end-column Ru(bpy)3(2+) ECL detection for the quantitative determination of pentoxyverine was firstly performed. The experimental conditions, such as the applied potential, injection voltage, injection time, and the pH of separation buffer, were discussed in detail. Gold nanoparticles were found to enhance the ECL intensity at an appropriate volume ratio of nanogold with Ru(bpy)3(2+) but without changing their nanoproperties proved by transmission electron microscopy (TEM) and UV-vis spectra. The detection limits with or without nanogold were 6 nM and 0.6 microM, respectively. Successful separation of pentoxyverine, chlorpheniramine, and lidocaine was achieved. This method was also applied to monitor drug binding with HSA, and the binding constant for pentoxyverine was estimated as 1.8 x 10(3)/M.