The first total syntheses of (+)-7-deoxynogarol (2) and (+)-7-con-O-methylnogarol (3), the notable members of nogalamycin congeners, were achieved employing the Diels-Alder reaction of the highly functionalized dienes (11 and 20) with the (+)-naphthoquinone (6), the CDEF-ring system of nogalamycin congeners, as a key synthetic step. 相似文献
Described is a system using heteropoly-11-tungstates as homogeneous catalysts for the oxidation of cyclohexene with hydrogen peroxide. The catalyst is dissolved in an organic solvent while the oxidant resides in the aqueous phase. The efficiency is high. 相似文献
A mild method of N-debenzylation via photosensitized single electron transfer (SET) using 9, 10-dicyano anthracene (DCA) as electron acceptor in neutral medium is reported. 相似文献
The pure rotational Raman spectrum of pyrazine, C4H4N2, has been observed for the first time. The spectrum was recorded photographically using a 3 m spectrograph with a reciprocal linear dispersion of 1.4 cm−1 mm−1. The following rotational constants were obtained: . 相似文献
The S21 lines of the OH radical for the A2Σ+ (v′ = 1)←X2Π (v″ = 0) transition have been observed in the 278–280 nm region from the laser-excitation spectrum. The OH radical was generated from either the H + NO2 or the H + O3 reaction in a flow system and the fluorescence passing through a 309.6 nm interference filter was detected with a photomultiplier-boxcar integrator arrangement. The weak S21 lines were observed at laser energies above 0.2 mJ. The observed peak wavenumbers are in excellent agreement with those predicted for the S21 bands of the A (v>′ = 1)←X (v″ = 0) transition from the known spectroscopic parameters. Observation of the corresponding S21 system for OD in the 286.0–286.9 nm region further confirms this assignment. The relative absorption cross-sections of about one-tenth those of the P1 lines are in good agreement with theoretical considerations. 相似文献
The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective, and sensitive UHPLC-Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin-Gu-Lian capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic acids, 14 phenylpropanoids, 12 phenols, eight alkaloids, four terpenes, three quinones, and one ketone. Among these, 21 compounds were clearly detected based on a comparison with reference standards and selected as quality control markers. Thereafter, these compounds were simultaneously determined in the Jin-Gu-Lian capsules. The established method was successfully validated and applied for the simultaneous determination of 21 biologically active compounds in Jin-Gu-Lian capsules of 27 sample batches. Quantitative data of the analytes were analyzed using multivariate statistical analysis to determine the quality of the Jin-Gu-Lian capsules. Four compounds (JGLC6 [salidroside], JGLC8 [chlorogenic acid], JGLC12 [liriodendrin], JGLC19 [quercetin]) were identified as chemical markers for quality control of Jin-Gu-Lian capsules. Altogether, the established method was validated as a novel and efficient tool, that can be used for rapid analysis of Jin-Gu-Lian capsules. Accordingly, this study serves as a reference for scientific research on traditional Chinese and ethnic medicine. 相似文献