Manganese (III) based oxidative free-radical cyclizations. 3. Polycyclization reactions proceeding through secondary radicals.

Oxidative cyclizations of 3, 14, 18 and 21 with Mn(OAc)₃ ·2H₂O give the tricyclic products 6, 15, 19 and 23, respectively, in good yield. These reactions proceed through a monocyclic secondary radical which adds to the benzene ring prior to the second oxidation.     

A nitrone-based approach to the synthesis of cis-3-amido azetidinones

The utilization of a nitrosation reaction in concert with a nitrone-based approach to the synthesis of important 3-oximino β-lactams, 7a, b, c is described.     

Development of a synthetic route towards milbemycin β1: Preparation of an advanced model system.

An advanced model compound for milbemycin β₁ synthesis has been prepared by a new coupling strategy employing alkylative rearrangement of a conformationally biased vinyl sulphone.     

Propargyl cations — powerful ambient temperature dienophiles in the diels-lder reaction

The diphenylpropargyl cation has been shown to be a powerful Diels-Alder dienophile which adds to dienes in high yield at ambient temperatures.     

Cooperative [2+2+2] cycloaddition reactions in polyquadricyclanylidene [n]rotanes - model studies in tris-spiro(C7H6) systems

Starting from biquadricyclanylidene, two substrates with three closely placed quadricyclanylidene units have been synthesized. In thermolysis and DMAD cycloaddition reactions, multiple intercyclic and potentially cooperative bond formation ([Π2+(σ2+σ2)₂]; [Π2+(σ2+σ2)₃]) has been realized.     

Photosensitized (set) conversion of 2′-hydroxychalcones to flavonoids a probable biogenetic pathway

2′-Hydroxychalcones undergo transformation to flavonoids by photoinduced single electron transfer processes.     

The Potential Antidepressant Action of Duloxetine Co-Administered with the TAAR1 Receptor Agonist SEP-363856 in Mice

Here, we explored the possible interaction between duloxetine and SEP-363856 (SEP-856) in depression-related reactions. The results showed that oral administration of duloxetine showed powerful antidepressant-like effects in both the forced swimming test (FST) and the suspension tail test (TST). SEP-856 orally administered alone also exerted an antidepressant-like effect in FST and TST, especially at doses of 0.3, 1, and 10 mg/kg. In addition, duloxetine (15 mg/kg) and SEP-856 (15 mg/kg) both showed antidepressant-like effects in the sucrose preference test (SPT). Most importantly, in the above experiments, compared with duloxetine alone, the simultaneous use of duloxetine and SEP-856 caused a more significant antidepressant-like effect. It is worth noting that doses of drug combination in FST and TST did not change the motor activities of mice in the open-field test (OFT). Thus, duloxetine and SEP-856 seem to play a synergistic role in regulating depression-related behaviors and might be beneficial for refractory depression.