A novel base-promoted synthesis of β-indolylketones via a three-component condensation under ultrasonic irradiation

A convenient, efficient, and practical method for the synthesis of β-indolylketones via a condensation of indole, aromatic aldehydes, and deoxybenzoin under ultrasonic irradiation was described. It provided a novel base-promoted approach for the one-pot synthesis of β-indolylketones.     

微喷管数值模拟

本文数值模拟喉部半高为34μm的二维微喷管,分别分析了固定进口及固定喉部尺度下扩张角、扩张比以及滑移边界条件对微喷管性能的影响,发现最佳半扩张角在20°-22°之间,而最佳扩张比为7。为了比较壁面滑移条件对计算结果影响,分别数值模拟了喉部尺寸为68μm和6.8μm的微喷管,发现Kn<0.001时,滑移边界条件对数值模拟结果较小;而0.002相似文献   

Indium-copper-mediated barbier-grignard-type alkylation reaction of imines in aqueous media

An efficient system of In/CuI/InCl3 was developed for Barbier-Grignard-type alkylation reactions of simple imines, using a one-pot condensation of various aldehydes, amines (including aliphatic and chiral version), and alkyl iodides in water or aqueous media. The reactions proceeded efficiently at room temperature to give the desired products in moderate to good yields. Good diastereoselectivities were obtained when using L-valine methyl ester as substrate.     

Axially chiral phosphine–oxazoline ligands in the silver(I)-catalyzed asymmetric Mannich reaction of fluorinated aldimines with trimethylsiloxyfuran

Axially chiral phosphine–oxazoline ligand L7, prepared from (S)-binol, was found to be a fairly effective chiral ligand in the silver(I)-catalyzed asymmetric Mannich reaction of fluorinated aldimines with trimethylsiloxyfuran to give the corresponding adducts in up to 99% yield, over 20:1 dr and 81% ee.     

新型手性桥连双-(1,5-二氮环辛烷)化合物的合成及其空间构象

由1，5-二氮环辛烷和手性酰胺醇3反应生成带手性侧臂的1，5-二氮环辛烷化合物2，后者与间二苄溴缩合得到新的桥连化合物1，其结构经元素分析，质谱，红外和^1H、^13C核磁等得到了证实，在合成的基础上，用分子力学MM2方法分析了化合物2和1的空间优势构象，取得了它们的最低能量值，和已知类似化合物的晶体结构相比较，确认了化合物优势构象的合理性，且易和金属离子形成稳定配合物。     

镍的锗化物与锗肖特基接触的工艺与特性

本文利用在n型Ge衬底上溅射金属Ni，然后在不同温度下氮气中退火的方法制备了Ni的锗化物肖特基二极管。X射线衍射（XRD）分析表明在Ge衬底上形成了一层Ni的锗化物。研究了退火温度对Ni的锗化物肖特基二极管电学特性的影响。实验结果表明具有典型I-V整流特性的肖特基二极管被获得，在300oC中退火的肖特基二极管的开关比最高。通过C-V方法提取了肖特基二极管的肖特基势垒高度。     

Ultrasound-promoted alkynylation of ethynylbenzene to ketones under solvent-free condition

This paper described alkynylation of ethynylbenzene to ketones catalyzed by potassium tert-butoxide under solvent-free conditions in the presence of ultrasound irradiation.     

Synthesis and Crystal Structure of (Z)-Ethyl-4-(4-methoxy)benzylidene-2-(3,5-dimethoxypheny-tetrahydrofuran-3,3-dicarboxylate

The title compound (Z)-ethyl-4-(4-methoxy)benzylidene-2-(3,5-dimethoxyphenyl)- tetrahydrofuran-3,3-dicarboxylate has been synthesized, and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P1-, with a = 8.140(3), b = 11.966(4), c = 13.771(5) α = 67.366(4), β = 85.165(5), γ = 75.806(4)°, V = 1200.1(7) 3, Z = 2, C26H30O8, Mr = 470.50, Dc = 1.302 g/cm3, F(000) = 500, λ(MoKα) = 0.71073 , μ = 0.096 mm–1, R = 0.0659 and wR = 0.1841 for 3080 observed reflections (I > 2σ(I)). As a key intermediate of HIV-1 integrase inhibitor, the synthesis and structure confirmation of the title compound are important for further studies.     

Preliminary Fluorimetric Screening of Fourteen Palladium Complexes as Potential Antitumor Agents

Making use of the fact that the combination of a drug substance with DNA may inhibit the duplication, synthesis and proliferation of DNA and the consistency of the in vivo and in vitro interactions, the authors worked out a preliminary screening method for testing complex agents as potential antitumor drugs using ethidium bromide as a fluorescence probe. In this report, the method was applied for in vitro testing fourteen synthesized palladium(Ⅱ)/phenanthroline/amino acid/chloride complexes as potential non-platinum antitumor agents. The fluorimetric screening method was compared with methylene blue tube test and trypan blue dye exclusion assay. All three methods gave agreeable results. Among the complexes tested, [Pd(phen)(lys)]Cl, [Pd(phen)(arg)]Cl and [Pd(phen)(pro)]Cl showed antineoplastic ratios for animal tumor S-180 56%, 50% and 48%, respectively, in accordance with the order of their binding constants with DNA, 7.96×10~6, 4.52×10~6 and 1.0×10~6, respectively. The test results show that fluor     

LED投影光源的色度学特性研究

利用色度学理论计算分析了传统弧光灯投影光源和LED投影光源两个实例的色度学特性，与传统弧光灯投影光源相比，LED投影光源具有更高的光谱能量利用率和更加丰富的色彩表现能力，完全符合数字投影机使用的sRGB彩色规范. 采用时序脉冲驱动的单色LED作为投影光源能够在不牺牲色彩饱和度的情况下获得更高亮度的投影显示. 因此LED可以替代传统的弧光灯光源以满足投影显示的色度特性要求. 关键词： 色度学特性 投影光源 LED 投影显示