自锚式斜拉-悬吊协作体系动力特性及模型试验研究

自锚式斜拉-悬吊协作体系桥作为一种新的大跨径桥型,综合了悬索桥和斜拉桥的特点,对其动力特性的研究十分重要.利用大型通用程序ANSYS建立空间有限元模型,用子空间迭代法对这种新型结构的动力特性进行了计算分析.同时通过动力模型试验对其动力特性进行研究,模型试验结果与理论分析相吻合,说明用现有的有限位移理论分析自锚式斜拉-悬吊协作体系的动力特性,并进行抗风、抗震设计是可靠的.     

In Vitro and In Vivo Antibacterial Activity,Toxicity and Resistance Analysis of Pleuromutilin Derivative Z33 against Methicillin-Resistant Staphylococcus aureus

The novel pleuromutilin derivative, which showed excellent in vitro antibacterial activity against MRSA, 22-(2-(2-(4-((4-(4-nitrophenyl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetamido)phenyl)thioacety-l-yl-22-deoxypleuromutilin (Z33), was synthesized and characterized in our previous work. In this study, the preliminary pharmacodynamics and safety of Z33 were further evaluated. In in vitro antibacterial activity assays, Z33 was found to be a potent bactericidal antibiotic against MRSA that induced dose-dependent growth inhibition and long-term post-antibiotic effect (PAE). The drug-resistance test demonstrated that Z33 possessed a narrow mutant selection window and lower propensities to select resistance than that of tiamulin. Cytochrome P450 (CYP450) inhibition assay determined that the inhibitory effect of Z33 was similar to that of tiamulin against the activity of CYP3A4, and was lower than that of tiamulin on the activity of CYP2E1. Toxicity determination showed that both Z33 and tiamulin displayed low cytotoxicity of RAW264.7 cells. Furthermore, Z33 was found to be a high-security compound with a 50% lethal dose (LD₅₀) above 5000 mg/kg in the acute oral toxicity test in mice. In an in vivo antibacterial activity test, Z33 displayed better therapeutic effectiveness than tiamulin in the neutropenic mouse thigh infection model. In summary, Z33 was worthy of further development as a highly effective and safe antibiotic agent against MRSA infection.     

基于Monte-Carlo法的冻土路基随机温度场分析

对青藏铁路沿线岩土热学参数进行统计分析,得出岩土的基本统计值及概率分布模式,采用基于Monte-Carlo法的随机有限元方法计算冻土区的路基随机温度场,得出随机温度场的均值和标准差.结果表明：路基的温度场均值和标准差分布趋势基本相似,且在路基上部和路基边坡面附近,其绝对值较大;温度的标准差在边界附近出现最大值,且沿边界向内而逐渐减小;在边界浅层区域,温度的标准差出现局部变化,到达一定深度后趋于稳定,并随着时间增加而增大,路基标准差区域从边界向内而逐渐扩大.     

复映射z←sinz2+c的广义M-J混沌分形图谱

推广了由多项式函数族构造的M J混沌分形系统,研究了复映射z←sinz2+c所构造的广义M集和J集,利用逃逸时间算法绘制了M集和J集的混沌分形图·通过大量计算机数学实验,找到了M集各主要周期芽苞的分布规律,并与具有典型意义的复映射z←z2+c所构造的M集进行了对比分析,指出了两者之间的异同·发现了复映射z←sinz2+c的广义J集的非连通特殊性,分析了图谱构成及周期点位置,指出其具有无穷嵌套、自相似的分形结构·通过研究各周期芽苞内的点所对应的J集分形图,得出了广义M集周期芽苞内点的周期数与相应J集吸引周期轨道周期数相等的结论,并讨论了M集与J集之间的对应关系·     

跨文化文献信息服务中文化冲突引发的问题与对策

分析了文献信息服务工作中文化冲突诱发的矛盾之因,提出了在文献信息服务工作中克服文化冲突诱发矛盾的方法与对策。     

组合式钢框架内填预制RC墙结构静力性能有限元分析

钢框架内填预制钢筋混凝土剪力墙结构是新型混合式结构,由钢框架与内填墙组成双重防线,具有良好的抗侧力能力,同时预制构配件和预制装配建筑有利于推动住宅产业化发展.考虑大尺寸内填预制RC墙运输和安装困难的情况,提出竖向和横向组合式钢框架内填RC墙结构,采用ABAQUS建立有限元模型进行结构受力分析.通过分析荷载位移曲线,构件应力分布和变形情况,研究结构破坏特点和受力性能.结果表明,全螺栓结构因其合理的传力路径,有良好的承载力和延性;竖向组合式具有较好的初始刚度和整体承载力,与全螺栓连接预制RC墙有近似的受力性能,便于运输和安装;而横向组合式由于上下板缺乏有效传力路径,初始刚度和最终承载力都明显低于全螺栓和竖向组合式,不利于实际工程应用.     

热喷涂技术及其在机械维修中的应用

介绍了热喷涂技术的相关概念、工艺过程、喷涂方法、技术特点、涂层与基体的结合以及在机械修复中的典型应用.实践结果表明：涂层成分、喷涂方法、喷涂参数等对涂层性能有直接影响,在机械零件与机械设备的维修方面应用广泛.     

Early Cambrian phosphatized blastula- and gastrula-stage animal fossils from southern Shaanxi

Marine invertebrate animal embryos and their early developmental products are of great significance to the study of taxonomy and phylogeny of early animals. A great number of phosphatized globular fossils were collected fromthe early Cambrian Kuanchuanpu Member (upper Dengying Formation), southern Shaanxi, and a nearly complete develo-pmental sequence—from a fertilized egg, via blastodisc formation, blastula development, blastodisc enlargement toward gastrulae, to tissue differentiation—can be discerned in this collection. This discovery provides unmatchable material for studies on the origin, taxonomy, radiation, and ontogeny of early metazoans.     

基于压缩感知的脉冲星轮廓构建算法

利用有限的观测时间获得高精度的累积脉冲轮廓,对于X射线脉冲星导航具有重要意义.提出一种基于压缩感知的脉冲星累积脉冲轮廓重构算法.首先,研究脉冲轮廓,获取先验知识,在此基础上构建波形匹配冗余词典,得到脉冲轮廓的稀疏表示;然后,设计观测矩阵,利用原始观测数据得到具有较少点数的非自适应随机测量值;最后,采用匹配追踪方法从随机测量值中恢复脉冲轮廓.利用罗希X射线探测器的实测脉冲星数据进行实验,结果表明：利用相同时段的观测数据,该算法得到的累积脉冲轮廓的信噪比远高于周期叠加方法得到的累积脉冲轮廓.     

基于能值改进生态足迹模型的全国省区生态经济系统分析

以我国1996,2000,2004,2008年各省区为例,分别采用传统生态足迹模型及基于能值改进生态足迹模型,从全国、地区、省区内3个层面,利用Theil系数进行区域可持续性及东、中、西部地区时空差异判定。结果表明：改进模型计算结果绝对数值明显高于传统模型,总体人均生态足迹、生态承载力及生态盈余与赤字区域排列均为东部〉...