THE STRUCTURAL BASIS OF THE POOR FIBRIN SPECIFICITY OF UROKINASE(Ⅰ)——KNOWLEDGE-BASED PREDICTION OF KRINGLE STRUCTURES OF UROKINASE AND ITS RELATED PROTEINS

The Kringle-1 structure of plasminogen (PGK-1), the Kringle-2 structure of tissue plasminogen activator (PAK-2) and the Kringle structure of prourokinase (UKK) has been modeled on the basis of the three-dimensional structure of Kringle-1 of prothrombin (PTK-1) at 2.8 resolution. The predicted three-dimensional structure of these Kringles shows that the binding site of PGK-1 is characterized by an apparent dipolar site, the polar parts of which are separated by a hydrophobic region. PAK-2 possesses the anionic center but has not a cationic binding center which might be provided by a guanidinium group from Arg-69 located adjacent to the Arg-71 position. UKK possesses neither the anionic binding center nor the cationic center which are probably the main reason for the poor fibrin specificity of urokinase.     

Analysis of Equilibrium and Kinetics of Chromium-Fluoride Complexation from Spectroscopic Data via Chemometrics Methods

IntroductionStudies on reversible kinetic systems are consi-dered as a hotspot of chemical and biochemical kineticresearches[1,2]. Of late, some researches have been fo-cused on the simultaneous optimization of the obverseand reverse rate constants[3,4].H…     

化学镀钴基合金镀液中钴的快速测定

研究了采用显色剂 苦胺酸偶氮变色酸对化学镀钴基合金镀液中钴含量进行测定的试验条件,在pH11的氨 氯化铵缓冲溶液中,钴与显色剂配合物的最大吸收峰在650nm波长处,钴(Ⅱ)在0～60μg/25ml范围内服从比耳定律,表观摩尔吸光系数为3.1×104L·mol-1·cm-1。该法测定钴的选择性好,在大量镍存在下,也能准确测定,对镀液样品进行了测定,相对标准偏差小于1%,结果满意。     

Synthesis, Structure and Conductivity of the New Charge-transfer Salt (ET)_2(CH_2=CH-CH_2-SO_3)·H_2O

ET is one of the most famous electron-donor molecules, which forms charge-transfer complexes (abbr. CT-complexes) with various types of counterions. These complexes have received intense attention because a wide range of physical properties such as conductivity and superconductivity1, ferromagnetism2-4 and nonlinear optical properties5 was found in these materials. Although the majority of the ET-based CT-complexes were prepared by combining with inorganic counterions, CT-complexes with o…     

信息类与感染类源语的改进与英译

根据纽马克的功能翻译类型学，本文提出译者有权修改信息类与感染类原文语言上的缺陷，举例讨论了缺陷的类型，其改正方法及改正后原文的翻译。鉴于目前基层企业这类送译稿数量巨大，其中不少在语言上有一定的缺陷，这种讨论具有较大的意义。     

音箱低频特性仿真软件的应用

介绍了倒相式音箱类比成集中参数等效电路的方法和音箱低频特性计算机辅助设计软件及其使用方法.选用Visual Fortran设计了一个实际音箱,实测结果与计算机仿真结果符合得很好.     

自然数幂和公式系数的递推公式和有关Bernoulli数的计算公式

研究了自然数幂和的表示公式,给出了其系数的一个递推关系式;利用递推关系式,得到幂和的各项系数,并由幂和公式的系数得到了计算Bernoulli数的几个计算公式.     

A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)

Severe Acute Respiratory Syndrome (SARS) is a newly identified infectious disease[1—5]. The global outbreak of SARS has been threatening the health of people worldwide and has killed 353 people and infected more than 5462 in 27 countries, as reported by WHO on April 29, 2003 (http://www.who.int/csr/sarscountry/en). Although it has been recognized that a variant of virus from the family of coronavirus might be the candidate pathogen of SARS[1—5], its identity as the unique pathogen sti…     

企业技术创新的关键在于企业与科技人员互动

企业技术创新要求企业与科技人员合作 ,合作的基础是利益诱导。在分析了企业与科技人员的利益目标差异的基础上 ,用一个抽象的组合激励理论模型 ,说明了两者“双赢”的行为选择 ,为推动企业技术创新提供了一种思路。     

分层海洋中大直径桩柱的波浪力

研究了在两层流体中大直径桩柱的水动力特性。基于分离变量方法，建立了绕射势的级数解，导出了作用于大直径桩柱上的绕射力的计算公式。与单层流体不同的是，对两层流体，由于内波的存在，作用在大直径桩柱上的绕射力，除了自由表面波绕射力外，还存在内波绕射力的作用。对所建立的绕射力的求解模型进行了数值模拟，并与单层流体的情况进行了比较，得到了一些有意义的结果。