大剂量多孔无针注射器结构优化

针对目前单孔无针注射器单次注射剂量小、需要多次重复注射的缺陷,提出一种大剂量多孔无针注射器.应用ANSYS Workbench仿真平台对多孔无针注射器的注射流场进行分析,发现多孔无针注射器的工作压力不低于13 MPa;并通过流固耦合分析,得到多孔无针注射器不同直径的应力变化规律,且拟合了不同压力下许用应力与最小安瓿直径之间的关系多项式.根据仿真结果设计正交试验对多孔无针注射器收缩段进行结构优化,得到优化方案：20°收缩角、1.4的长径比、2 mm的分布圆直径、4.05 mm的收缩段长度和0.165 mm的微孔直径.且通过安瓿的应力分析,验证了优化方案满足材料的力学性能要求.优化结果表明,该注射器具有比传统单孔注射器更大的注射剂量,可达5 mL,注射速度高达150 m/s以上,能击穿皮肤,同时又不致造成过多损伤.试验及动力学分析进一步验证了优化方案的可行性.     

考虑人-车-路耦合的路径跟随过程操稳性预测研究

为更早预测车辆的操稳性失稳风险,针对性解决传统“人-车-路”耦合系统中“路”先验信息未知和由此导致的“人”输入难预测问题,借助先进辅助驾驶系统提供的前方预瞄路径,提出结合驾驶员转向模型及车辆非线性动力学模型的操稳性预测方法. 构建“人-车-路”闭环反馈驾驶员模型,对跟随道路曲率的驾驶员转向行为进行预测;将当前车速与预测转向作为三自由度非线性动力学模型的输入,实现跟随前方路径的操稳性状态预测;通过Simulink-Carsim联合仿真及驾驶员模拟器硬件在环对比,进行双移线路径、变曲率路径和蛇形路径工况模拟. 所提方法的操稳性状态预测值与实际值吻合良好.     

化学活性表面的分形研究

利用近十年来兴起的分形几何学,对固体表面进行了研究,指出固体表面的粗糙程度及不规则性可以用分形维数给予很好的定量描述,并给出了测定化学活性固体表面分形维数的方法。     

复合式有源消声耳罩控制器的优化设计

探讨了复合式有源消声耳罩的控制器的优化设计方法。以闭环二阶控制器为例,推导了优化设计的目标函数,探讨了约束条件的确定和优化方法的选择。对于优化设计中出现的尖峰现象、中间频率点的稳定性等问题进行了分析,并给出了解决方法。还给出了理论计算效果与实验结果的比较,验证了优化设计方法的有效性。     

Design and Synthesis of 1-Benzyl-3-(a-hydroxy-(un)substituted benzylidene)pyrrolidine-2,4-diones as Potential Herbicides

The inhibitors of 4-hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) are an new kind of herbicides.[1]Generally, in structure, potent herbicides of this kind must possess: (1) a tricarbonyl methane structure and one of the three carbonyl groups must be a subustituted benzoyl group; (2) the compound must be able to enolise so that the enolate is capable of inhibiting HPPD enzyme by competitive combination with Fe2+, the reaction center of HPPD enzyme.[2]Recently, we noticed that the 3-acyltetramic acids form an expanding group of antibiotics and pigments from micro-organisms,[3] they display a range of biological activities[4] and all of this kind compounds possess all of the characters mentioned above. Tests of their antimicrobial activities indicated that the structure of the acyl substituent at the 3-position was important to many typical antibiotics.[4～6] These characters stimulated us to study this kind of compounds so as to discover new herbicides. In this report, we synthesized a series of compounds 3 and tested their herbicidal activities to investigate their structure-activity relationships.     

THE STRUCTURAL BASIS OF THE POOR FIBRIN SPECIFICITY OF UROKINASE(Ⅰ)——KNOWLEDGE-BASED PREDICTION OF KRINGLE STRUCTURES OF UROKINASE AND ITS RELATED PROTEINS

The Kringle-1 structure of plasminogen (PGK-1), the Kringle-2 structure of tissue plasminogen activator (PAK-2) and the Kringle structure of prourokinase (UKK) has been modeled on the basis of the three-dimensional structure of Kringle-1 of prothrombin (PTK-1) at 2.8 resolution. The predicted three-dimensional structure of these Kringles shows that the binding site of PGK-1 is characterized by an apparent dipolar site, the polar parts of which are separated by a hydrophobic region. PAK-2 possesses the anionic center but has not a cationic binding center which might be provided by a guanidinium group from Arg-69 located adjacent to the Arg-71 position. UKK possesses neither the anionic binding center nor the cationic center which are probably the main reason for the poor fibrin specificity of urokinase.     

Interaction of tetrandrine with human serum albumin: a fluorescence quenching study.

The interaction of tetrandrine with human serum albumin (HSA) was studied by measuring fluorescence quenching spectra, synchronous fluorescence spectra and ultra-violet spectra. The fluorescence quenching spectra of HSA in the presence of tetrandrine showed that tetrandrine quenched the fluorescence of HSA. The quenching constants of tetrandrine on HSA were determined using the Stern-Volmer equation. Static quenching and non-radiation energy transfer were the two main reasons leading to the fluorescence quenching of HSA by tetrandrine. According to the F?rster theory of non-radiation energy transfer, the binding distances (r) and the binding constants (K(A)) were obtained. The thermodynamic parameters obtained in this study revealed that the interaction between tetrandrine and HSA was mainly driven by a hydrophobic force. The conformational changes of HSA were investigated by synchronous spectrum studies.     

Analysis of Equilibrium and Kinetics of Chromium-Fluoride Complexation from Spectroscopic Data via Chemometrics Methods

IntroductionStudies on reversible kinetic systems are consi-dered as a hotspot of chemical and biochemical kineticresearches[1,2]. Of late, some researches have been fo-cused on the simultaneous optimization of the obverseand reverse rate constants[3,4].H…     

New Nitrogenous Bisabolene‐Type Sesquiterpenes from a Hainan Sponge Axinyssa aff. variabilis

Two new uncommon nitrogenous sesquiterpenes, 11‐ethoxy‐3‐formamidotheonellin ( 1 ) and 7‐ethoxy‐3‐formamidobisabolane‐8,10‐diene ( 2 ), together with two known related sesquiterpenes, 3‐formamidotheonellin (=theonellin formamide; 3 ) and theonellin isothiocyanate ( 4 ), were isolated from the Hainan sponge Axinyssa aff. variabilis. Their structures were determined on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those of known compounds.     

化学镀钴基合金镀液中钴的快速测定

研究了采用显色剂 苦胺酸偶氮变色酸对化学镀钴基合金镀液中钴含量进行测定的试验条件,在pH11的氨 氯化铵缓冲溶液中,钴与显色剂配合物的最大吸收峰在650nm波长处,钴(Ⅱ)在0～60μg/25ml范围内服从比耳定律,表观摩尔吸光系数为3.1×104L·mol-1·cm-1。该法测定钴的选择性好,在大量镍存在下,也能准确测定,对镀液样品进行了测定,相对标准偏差小于1%,结果满意。