Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide

Lipid A is the causative agent of Gram-negative sepsis, a leading cause of mortality among hospitalized patients. Compounds that bind lipid A can limit its detrimental effects. Polymyxin B, a cationic peptide antibiotic, is one of the simplest molecules capable of selectively binding lipid A and may serve as a model for further development of lipid A binding agents. However, association of polymyxin B with lipid A is not fully understood, primarily due to the low solubility of lipid A in water and inhomogeneity of lipid A preparations. To better understand lipid A-polymyxin B interaction, pure lipid A derivatives were prepared with incrementally varied lipid chain lengths. These compounds proved to be more soluble in water than lipid A, with higher aggregation concentrations. Isothermal titration calorimetric studies of these lipid A derivatives with polymyxin B and polymyxin B nonapeptide indicate that binding stoichiometries (peptide to lipid A derivative) are less than 1 and that affinities of these binding partners correlate with the aggregation states of the lipid A derivatives. These studies also suggest that cooperative ionic interactions dominate association of polymyxin B and polymyxin B nonapeptide with lipid A.     

Luminescent heteronuclear Au(I)5Ag(I)8 complexes of [1,2,3-C6(C6H4R-4)3]3- (R = H, CH3, But) by cyclotrimerization of arylacetylides

Unusual AuI-AgI heterometallic complexes [Au5Ag8(mu-dppm)4{1,2,3-C6(C6H4R-4)3}(CCC6H4R-4)7]3+ (R = H 1, CH3 2, But 3) were isolated by reactions of polymeric silver arylacetylides (AgCCC6H4R-4)n with binuclear gold component [Au2(mu-dppm)2(MeCN)2]2+ (dppm = bis(diphenylphosphino)methane), in which cyclotrimerization of arylacetylide -CCC6H4R-4 affords trianion {1,2,3-C6(C6H4R-4)3}3- with an unprecedented mu5-bonding mode. Compounds 1(SbF6)3-3(SbF6)3 exhibit intense photoluminescence derived from an MLCT (Au5Ag8 --> CCC6H4R-4) transition, mixed with a metal cluster-centered excited states.     

试论学生体育骨干的作用与培养

本文阐述了学生体育骨干在学校体育工作的作用,分析了培养学生体育骨干在学校体育工作中的重要性和必要性,并在选拔和培养学生体育骨干的方式方法上进行了探讨.     

提高供氧能力对土曲霉生产衣康酸的影响

本文研究了供氧能力对土曲霉ＩＦＯ－６３６５分批发酵生产衣康酸能力的影响。当通风比为０．５Ｖ．Ｖ．ｍ，搅拌叶轮末端线速度为１２５．７ｃｍ／ｓ时的最大衣康酸发酵产率分别是叶轮末端线速度为９４．２ｃｍ／ｓ和７８．５ｃｍ／ｓ的１．２８倍和３倍；当添加氧载体──正十二烷，叶轮末端线速度为７８．５ｃｍ／ｓ时，与对照相比，可提高产酸１４％，但在更高的叶轮末端线速度条件下，加入正十二烷，只能促进菌体的生长，对发酵产酸是抑制作用。     

论西兰卡普图案的艺术特征及应用

中国土家民族的织锦“西兰卡普”有着独特的图案特色和个性特征。本文从视觉艺术的角度，通过对西兰卡普图案的内容与造型形式、图案的意象表现及象征意义的分析，探索具有民间艺术特征和以民间视觉艺术审美为基础的织锦文化——西兰卡普图案及其应用。     

浅析补偿法在物理题解中的应用

补偿法是研究和求解物理学问题的一种有效的方法，它能将物理问题化难为易，化繁杂为简单．本文主要从力学、电磁学等方面介绍了补偿法在物理题解中的广泛应用．     

二级倒立摆的三种控制方法比较

通过采用LQY最优控制、变结构控制及模糊控制3种方法对二级倒立摆系统进行实时控制,从理论上讨论了这类典型的非线性自不稳定系统控制器的设计方法,通过分析指出各种方法之间的优缺点,并通过数字仿真加以证实。     

飞机结构撞击损伤预测的现状及发展

从弹道极限、剩余速度、剩余质量、未击穿及击穿条件下损伤尺寸预测等方面对飞机结构撞击损伤的预测进行了分析，并对损伤预测的发展趋势进行论述，提出今后损伤预测研究的主要方向和手段。     

高校图书馆在网络道德教育中的作用

分析了对大学生进行网络道德教育的必要性和紧迫性，并探讨了大学生网络道德教育的内容与方式以及高校图书馆在网络道德教育中应采取的对策。     

电子商务对会计的影响

在简要介绍电子商务概念的基础上，从电子商务对传统的会计假设理论的冲击、对会计核算形式的影响、对会计核算原则的影响、使传统内部会计控制制度失效、对会计人员的要求5个方面论述了电子商务对会计的影响。