老年人的合理用药

老年人由于组织器官的老化和功能减退，影响药物的吸收、分布、代谢和排泄。为确保老年患者的用药安全，应提高老年人的合理用药水平。     

Synthesis and Crystal Structure of 3,3‘—（Hexane—1,6—diyl）bis（1—acetyl—5,5—dimethylhydantoin）,a New Inducer of Differentiation

The title compound C20H30N4O6, Mr = 422.48)was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in the triclinic system, space group P ī with cell parameters: a = 8.330(2), b = 8.468(2), c = 16.017(3) A, α = 97.30(3), β = 92.33(3), γ = 103.94(3)o, V = 1084.7(4) A3, Dc = 1.294 g/cm3, Z = 2, F(000) = 452 and μ = 0.096 mm-1. The structure was refined to R = 0.0483 for 3732 observed reflections with I>2(I) and wR = 0.1335 for 4828 unique reflections. The hydantoin rings are planar and the two ring planes of one molecule are paralleled to each other.     

超临界CO2中甲醇和乙醇无限稀释扩散系数的分子动力学模拟与实验测定

采用分子动力学模拟(MD)方法对甲醇和乙醇在超临界二氧化碳中的无限稀释扩散系数进行了模拟计算, 并应用泰勒分散理论, 采用超临界色谱仪对模拟结果进行了实验验证. 模拟计算值与实验值较吻合, 且变化规律基本一致, 表明采用这种新方法可以准确有效地预测超临界体系的扩散性质, 能够方便地应用于工程设计.     

Crystal Structure, Thermal Stability and Luminescence of Coordination Polymer [Cd（BBP）（p-PDOA）]n

Hydrothermal reaction of Cd（NO3）2·4H2O with bbp and p-PDOAH2 at 140 ℃ yielded a novel 1D cadmium（Ⅱ） coordination polymer, [Cd（bbp）（p-PDOA）]n （bbp=2,6-bis（benzimidazol-2-yl）pyridine, p-PDOA=p-phenylenedioxydiacetate dianion）, in which CdN3O4 pentagonal bipyramids were linked by p-PDOA ligands in a bis-bidentate mode to construct a zigzag chain with the adjacent Cd…Cd distance of 1.14（1） nm, There exists a 2D supramolecular network linked by π-π stacking with a face-to-face distance of 0.35（1） nm between the 2,6-bis（benzimidazol-2-yl） pyridine ligands and hydrogen-bonding interactions （0.27（4） nm）. A 3D supramolecular network was further constructed by these non-covalent interactions between the zippers. The TG/DTG showed that its chain skeleton was thermally stable up to 389 ℃ and the blue fluorescent emission of the complex was determined at 428 nm in a solid state with its long decay lifetime of 7.24 ns.     

Synthesis and Crystal Structure of (2S,2'S,4'R)-2-(1-Hydroxy-1-ethylpropyl)-1-[(1'-p-tosyl-4'-hydroxypyrrolidin-2'-yl)methyl]pyrrolidine

1 INTRODUCTION In recent years, chiral β-amino alcohols have attracted much attention due to their special bio- logical functions and catalytic activities. Chiral β- amino alcohol moieties are usually found not only in natural products (e.g., cinchona alkaloids, ephe- drine, toxal, etc.) with special biological activities[1, 2], but also critical structural segments of some syn- thesized biologically active compounds, such as adrenergic agonists or antagolist[3, 4] and inhibitors for HI…     

非晶态NiP（B）／Al2O3催化一氧化碳，水和氧气合成过氧化氢

Hydrogenperoxideisagreenoxidantwithgreatpotentialformuchapplication .Thepresentproduc tionofhydrogen peroxiderequiressevereconditionsand generates pollutants .AlternativesynthesesarerequiredandthesynthesisofH2 O2 fromCO ,H2 OandO2 isverypromising .AsshowninEq(1) ,thesynthesisisthermodynamicallyfavored :CO +H2 O +O2 H2 O2 +CO2 (1)ΔG02 98=- 134kJ/mol　　ThereactionwasfirstreportedbyZudinetal[1]whousedpalladiumtriphenylphosphaneasacatalyst.Bianchietal[2 ] usedabiphasesystemforthesynthe …     

Intrinsic Surface Reaction Constant in 1-pK Model of Mg-Fe Hydrotalcite-like Compounds

The relationship among intrinsic surface reaction constant (K) in 1-pK model, point of zero net charge (PZNC) and structural charge density (σst) for amphoteric solid with structural charges was established in order to investigate the effect of σst on pK. The theoretical analysis based on 1-pK model indicates that the independent PZNC of electrolyte concentration (c) exists for amphoteric solid with structural charges. A common intersection point (CIP) should appear on the acid-base titration curves at different c, and the pH at the CIP is pHPZNC. The pK can be expressed as pK=-pHPZNC log[(1 2αPZNC)/(1-2αPZNC)], where αPZNC≡σst/eNANs, in which e is the elementary charge, NA the Avogadro‘s constant and Ns the total density of surface sites. For solids without structural charges, pK=-pHPZNC. The pK values of hydrotalcite-like compounds (HTlc) with general formula of [Mg1-xFex(OH)2](Cl,OH)x were evaluated. With increasing x, the pK increases, which can be explained based on the affinity of metal cations for H^- or OH^- and the electrostatic interaction between charging surface and H^- or OH^-.     

系列单取代烷氧基-2-羟丙基-β-环糊精的合成与表征

以环氧氯丙烷和脂肪醇为原料, 通过相转移催化法合成了乙基、正丙基、正丁基和正戊基缩水甘油醚(1～4), 并利用所合成的缩水甘油醚和β-环糊精为原料, 分别在弱碱水溶液(1.5%)和强碱水溶液(30%)中制备并用硅胶柱分离出单2位取代的乙氧基、丙氧基、丁氧基和戊氧基-2-羟丙基-β-环糊精(1a～4a)和单6位取代的丙氧基、丁氧基和戊氧基-2-羟丙基-β-环糊精(2b～4b), 利用薄层色谱、红外光谱、差热扫描量热分析、质谱和核磁共振等手段对所合成的产品进行了表征.     

3-芳基-6-对甲苯甲酰氨基均三唑并[3,4-b]-1,3,4-噻二唑的合成及生物活性

利用3-芳基-4-氨基-5-巯基-1,2,4-均三唑和对甲苯甲酰异硫氰酸酯在乙腈中反应, 得到一系列3-芳基-6-对甲苯甲酰氨基均三唑并[3,4-b]-1,3,4-噻二唑, 用¹H NMR, IR, MS和元素分析确定了其结构, 并对其进行了抗菌活性测试.     

混合价化合物的研究(Ⅱ)─—电化学及现场光谱电化学方法研究非质子介质中Dawson结构杂多阴离子[HAs_2Mo_(18)O_(62)]~(n-)的电还原性质

以电化学和现场紫外－可见－近红外及现场FTIR光谱电化学方法对Dawson结构杂多阴离子［HAS2Mo18O62］5－在非质子介质（CH3CN）中的电还原过程进行了研究．结果表明，该杂多阴离子在非质子介质中经历4步单电子还原反应，所产生的杂多蓝阴离子在近红外区出现宽广的价间电荷转移吸收带，而红外区Mo＝O端键及Mo—O—Mo桥键的特征吸收峰在还原后均有不同程度的红移．