论我国高新技术产业园区的区域创新网络建设

大量的研究表明硅谷等高新区发展的关键,在于园区内形成了一个完善的区域创新网络,所以建立完善的区域创新网络对我国高新区的发展是至关重要的。文章首先分析了区域创新网络的概念及特征;其次,分析了区域创新网络对高新技术产业发展的作用与影响;第三,指出了目前我国高新技术产业园区内区域创新网络建设存在的问题;最后,就如何培育区域创新网络,促进我国高新区发展提出了对策及建议。     

热机电耦合智能板结构的一类有限元模型

针对热机电压电薄板结构,提出了一种包含4个位移节点、2个电势节点和8个温度节点的有限元模型,其位移场按平板壳单元描述,而电势场和温度场则按线性插值方法描述,并基于虚功原理导出了热机电有限元方程,通过比较,表明所得有限元方程的正确性.最后以悬臂板为例,对位移响应、温度响应和输出电压进行了数值仿真,凸现了在小挠度变形下,变化幅值较大的温度对输出电压的重大影响.     

808 nm InGaAsP-InP单量子阱激光器热特性研究

从InGaAsP-InP单量子阱激光器结构分析入手,采用自行设计的热封闭系统对808 nm InGaAsP-InP单量子阱激光器热特性进行了研究.实验表明,在23-70℃的温度范围内,器件的功率由1.74 W降到0.51 W,斜率效率由1.08 W/A降到0.51 W/A.实验测得其特征温度T0为325 K.激射波长随温度的漂移dλ/dT为 0.44 nm/℃.其芯片的热阻为3.33℃/W.     

Effect of enzymatic fish frame protein hydrolysate on freeze-induced denaturation of myofibrillar protein from bighead carp fish （Aristichthys nobilis ） during frozen storage

Three kinds offish frame protein hydrolysates （PPH, APH and FPH） were prepared from fish frame of red drum （ Sciaenops ocellatus ） by papain, alkaline proteinase and flavorzyme treatment. The hydrolysates were mainly composed of peptide （83.5 % -84.6% ） and displayed different molecular weight distribution pattern. The protective effects of hydrolysates on the freeze-induced denaturation of myofibrillar protein （Mf） from bighead carp （Aristichthys nobilis） mince during storage at -20℃ for 12 weeks were investigated. The hydrolysate （5 % dried weight/wet weight） reduced the freeze-induced denaturation of Mf as evidenced by the lowered decrease in Ca-ATPase activity and reactive sulfllydryl contents as well as the impeded increase in surface hydrophobicity. Microscopic photographs indicated that the hydrolysates inhibited the growth of ice crystal in fish mince, and then prevented the aggregation of Mf during frozen storage. The protective effects of hydrolysates on freeze-induced denaturation of Mf were influenced by the molecular weight distribution. PPH had strongest cryoprotective ability among three hydrolysates.     

HPLC-MS/MS法同时测定牛肉中80种兽药及其代谢物

为全面排查宁夏地区牛肉兽药残留风险,从农业农村部规定的禁停用药物、GB 31650—2019《食品安全国家标准食品中兽药最大残留限量》中规定有最大残留限量的药物以及宁夏养殖环节大量使用药物三方面筛选确定12类药物,利用简单、快捷的前处理方法和超高效液相色谱-串联质谱多反应监测分析技术,建立了一次进样可同时分析检测12类80种兽药及其代谢物残留的快速检测方法。样品采用Oasis PRiME HLB固相萃取柱净化,经Waters HSS T3色谱柱分离,多反应监测模式监测,基质匹配外标法定量。结果表明:80种兽药及其代谢物在基质匹配标准溶液1.0～50.0μg/L的质量浓度范围内呈现良好的线性关系,相关系数均大于0.990,方法定量限在2.0～5.0μg/kg,方法在2.0～100.0μg/kg的平均回收率为60%～103%,相对标准偏差(n=5)均小于20%;应用该检测方法对40份市售牛肉进行检测,其中4份牛肉检出兽药残留,分别为土霉素(54.5μg/kg)、磺胺间甲氧嘧啶(23.3μg/kg和35.4μg/kg)及恩诺沙星(118μg/kg),再分别使用GB/T 21317—2007、GB/T 20759—2006、GB/T 21312—2007方法对阳性样品进行复检,结果一致。经验证表明:该检测方法定性定量结果准确可靠、灵敏度高、重现性好,可满足对牛肉中兽药残留检测分析的要求。     

缺血修饰白蛋白检测方法的分析性能评价

应用湖南长沙颐康科技开发有限公司开发的缺血修饰白蛋白(ischemia modified albumin,IMA)检测试剂盒,在OLYMPUS AU5400全自动生化分析仪上设计合理的实验参数,建立白蛋白-钴结合力(albumin cobalt binding,ACB)实验检测系统,用比色法测定IMA的浓度,参考美国临床实验室标准化协会(clinical and laboratory standards institute,CLSI)系列文件的要求,评价IMA检测系统的线性实验、精密度(用批内和批间变异系数CV表示)、干扰试验;收集表征健康人群血清(366例),检测该人群血清IMA浓度,建立本实验室的参考区间.结果表明白蛋白-钴结合线性分析方程式为y=1.470 6x+5.260 6,R2=0.974 8,线性良好;IMA的高、中、低值样本的批内CV和批间CV分别为3.01%和3.24%、2.63%和4.36%及4.77%和5.59%,均小于厂商说明书声明的5.06%和6.72%,表明本实验检测系统精密度性能符合临床实验室质量目标管理的要求.高、低两个浓度标本在干扰物为临床标本时可能出现的最高含量(甘油三酯8.5mmol/L、胆红素75.2mmol/L、血红蛋白160g/L)结果测定值均在95%置信区间内,表明在临床实验室该方法抗干扰性能良好;健康人群IMA的本实验室的参考区间为IMA>65.2U/mL.     

Planar monolithic porous polymer layers functionalized with gold nanoparticles as large-area substrates for sensitive surface-enhanced Raman scattering sensing of bacteria

For the first time, large-area surface-enhanced Raman scattering sensing active substrates using porous polymer monolithic layers have been successfully prepared. Our approach includes a simple photoinitiated polymerization process using glycidyl methacrylate and ethylene dimethacrylate in a glass mold, followed by a chemical reaction of the epoxy functionalities leading to thiols, and the attachment of preformed gold nanoparticles. We demonstrated that this very simple process produced uniform and reproducible large area surfaces that significantly enhance sensitivity of Raman spectroscopy. Experiments were also carried out that confirmed preferential adsorption of living bacteria Escherichia coli from a very dilute solution on the surface of the monolithic layer, and immediate detection of the captured microorganisms using the SERS spectrum.     

YVO4/Nd:YVO4/YVO4 self-Raman laser at 1,764 nm

A diode-end-pumped composite YVO₄/Nd:YVO₄/YVO₄ crystal self-Raman laser at the second-Stokes wavelength of 1,764 nm is demonstrated. The maximum average output power of second-Stokes radiation was up to 0.99 W at a pump power of 34 W and a pulse repetition frequency of 20 kHz, corresponding to an optical conversion efficiency of 2.9 %. The highest peak power and the shortest pulse duration were 21.5 kW and 1.92 ns, respectively.     

高等数学学习方法指导的改革与实践

学习科学已经发展为一个学科群，作为学习科学的重要组成部分，高等数学学习方法指导的研究也警来越受到人们的重视，本文通过对高等数学学习方法指导的现状的剖析，提出高等数学学习方法改革的基本思路.