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941.
Functionalization of magnetic nanoparticles with dendritic-linear-brush-like triblock copolymers and their drug release properties 总被引:1,自引:0,他引:1
X He X Wu X Cai S Lin M Xie X Zhu D Yan 《Langmuir : the ACS journal of surfaces and colloids》2012,28(32):11929-11938
Novel water-soluble dendritic-linear-brush-like triblock copolymer polyamidoamine-b-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) (PAMAM-b-PDMAEMA-b-PPEGMA)-grafted superparamagnetic iron oxide nanoparticles (SPIONs) were successfully prepared via a two-step copper-mediated atom transfer radical polymerization (ATRP) method. The macroinitiators were immobilized on the surface of Fe(3)O(4) nanoparticles via effective ligand exchange of oleic acid with the propargyl focal point PAMAM-typed dendron (generation 2.0, denoted as propargyl-D(2.0)) containing four carboxyl acid end groups, following a click reaction with 2'-azidoethyl-2-bromoisobutylate (AEBIB). PDMAEMA and PPEGMA were grown gradually from nanoparticle surfaces using the "grafting from" approach, which rendered the SPIONs soluble in water and reversed aggregation. To the best of our knowledge, this is the first report that describes the functionalization of magnetic nanoparticles with dendritic-linear-brush-like triblock copolymers. The modified nanoparticles were systematically studied via TEM, FT-IR, DLS, XRD, NMR, TGA, and magnetization measurements. DLS measurement confirmed that the obtained dendritic-linear-brush-like triblock copolymer-grafted SPIONs had a uniform hydrodynamic particle size of average diameter less than 30 nm. The dendritic-linear-brush-like triblock copolymer-grafted SPIONs possessed excellent biocompatibility by methyl tetrazolium (MTT) assays against NIH3T3 cells and hemolysis assays with rabbit erythrocytes. Furthermore, an anticancer drug, doxorubicin (Dox), was used as a model drug and loaded into the dendritic-linear-brush-like triblock copolymer-grafted SPIONs, and subsequently, the drug releases were performed in phosphoric acid buffer solution pH = 4.7, 7.4, or 11.0 at 37 °C. The results verify that the dendritic-linear-brush-like triblock copolymer-grafted SPIONs possess pH-responsive drug release behavior. The Dox dose of the loaded and free drug required for 50% cellular growth inhibition was 2.72 and 0.72 μm/mL, respectively, according to MTT assay against a Hella cell line in vitro. Therefore, on the basis of its biocompatibility and drug release effect, the modified SPION could provide a charming opportunity to design some excellent drug delivery systems for therapeutic applications. 相似文献
942.
Xiaohua He Liang Zhong Xiaomeng Wu Xin Cai Meiran Xie Shaoliang Lin Deyue Yan 《Journal of polymer science. Part A, Polymer chemistry》2012,50(14):2841-2853
A series of novel amphiphilic brush‐dendritic‐linear poly[poly(ethylene glycol) methyl ether methacrylate]‐b‐polyamidoamine‐b‐poly(ε‐caprolactone) copolymers (PPEGMEMA‐b‐Dm‐b‐PCL) (m = 1, 2, and 3: the generation number of dendron) were synthesized by the combination techniques of click chemistry, atom transfer radical polymerization (ATRP), and ring‐opening polymerization (ROP). The brush‐dendritic copolymers bearing hydrophilic brush PPEGMEMA and hydrophobic dendron polyamidoamine protected by the tert‐butoxycarbonyl (Boc) groups [Dm‐(Boc) (m = 1, 2, and 3)] were for the first time prepared by ATRP of poly(ethylene glycol) methyl ether methacrylate monomer (PEGMEMA) initiated with the dendron initiator, which was prepared from 2′‐azidoethyl‐2‐bromoisobutyrate (AEBIB) and Dm‐(Boc) terminated with a clickable alkyne by click chemistry. Then, the brush‐dendritic copolymers with primary amine groups (PPEGMEMA‐b‐Dm) were obtained from the removal of the protected Boc groups of the brush‐dendritic copolymers in the presence of trifluoroacetic acid. The brush‐dendritic‐linear PPEGMEMA‐b‐Dm‐b‐PCL copolymers were synthesized from ROP of ε‐caprolactone monomer using PPEGMEMA‐b‐Dm as the macroinitiators and stannous octoate as catalyst in toluene at 130 °C. To the best of our knowledge, this is the first report that integrates hydrophilic brush polymer PPEGMEMA with hydrophobic polyamidoamine (PAMAM) dendron and PCL to form amphiphilic brush‐dendritic‐linear copolymers. The amphiphilic brush‐dendritic‐linear copolymers can self‐assemble into spherical micellar structures in aqueous solution. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 相似文献
943.
944.
Andreas Mautner Xiaohua Qin Barbara Kapeller Guenter Russmueller Thomas Koch Juergen Stampfl Robert Liska 《Macromolecular rapid communications》2012,33(23):2046-2052
Vinyl carbonates have recently been identified as a suitable alternative to (meth)acrylates, especially due to the low irritancy and cytotoxicity of these monomers. The drawback of some vinyl carbonates containing abstractable hydrogens arises through their moderate reactivity compared with acrylates. Within this paper, we use the thiol‐ene concept to enhance the photoreactivity of vinyl carbonates to a large extent to reach the level of those of similar acrylates. Mechanical properties of the final thiol‐ene polymers were determined by nanoindentation. Furthermore, low toxicity of all components was confirmed by osteoblast cell culture experiments. 相似文献
945.
Lidan Deng Wei Shen Xiaohua Xie Liusheng Jiang Binyao Liu Ming Li 《Structural chemistry》2012,23(1):97-106
The structures and properties of dibenzo[b,d]thiophene (DBT) based alternating donor–acceptor conjugated oligomers, in which thieno[3,4-b]pyrazine (TP), thieno[3,4-b]thiadiazole (TD), and [1,2,5]thiadiazolo[3,4-e]thieno[3,4-b]pyrazine (TTP) as acceptors, and their periodic polymers were investigated by the density function theory (DFT) at the B3LYP/6-31G(d)
level. The bond length, electron density at bond critical points (BCPs) and nucleus-independent chemical shift (NICS) are
analyzed and correlated with the conductive properties. NICS shows that the conjugation degree is increased with main chain
extension. Research results show the conductive ability of compounds with 1:2 D–A ratio is better than that with 1:1 D–A ratio.
The reorganization energies and energy bands also are considered. The results suggest that (BTDDBT)
n
and (BTPDDBT)
n
have small reorganization energy (0.163 and 0.152 eV, respectively) and quite low energy gap (0.73 and 0.56 eV, respectively),
which indicate that they may be potential organic conductive materials. 相似文献
946.
Let L be a non-negative self-adjoint operator acting on L2(X) where X is a space of homogeneous type. Assume that L generates a holomorphic semigroup e−tL which satisfies generalized m-th order Gaussian estimates. In this article, we study singular and dyadically supported spectral multipliers for abstract self-adjoint operators. We show that in this setting sharp spectral multiplier results follow from Plancherel or Stein–Tomas type estimates. These results are applicable to spectral multipliers for a large class of operators including m-th order elliptic differential operators with constant coefficients, biharmonic operators with rough potentials and Laplace type operators acting on fractals. 相似文献
947.
全冠义齿碰撞检测算法研究与应用 总被引:1,自引:1,他引:0
全冠义齿数字化设计中,针对变形牙冠与非变形牙冠碰撞检测问题,提出一种基于动态混合包围盒的碰撞检测算法。首先,在预处理阶段为非变形牙冠建立,包含AABB和OBB包围盒的混合包围盒。设计过程中查询变形模型处于非变形模型AABB包围盒内的数据,为其建立局部动态AABB包围盒,将它与非变形模型的OBB包围盒进行碰撞检测,返回干涉图元的交线。之后,查询干涉区域并计算刺穿深度,将结果以色阶图的形式返回。碰撞检测效率高,可达到实时响应,色阶图结果清晰直观,为牙冠设计提供明确的操作依据。 相似文献
948.
Xuan He Xin Cui Maosi Li Lili Lin Xiaohua Liu Xiaoming Feng 《Tetrahedron letters》2009,50(42):5853-5856
A highly enantioselective fluorescent sensor, containing benzylaminomethyl groups at 3,3′-position of 1,1′-bi-2-naphthol (BINOL), has been used to conduct the chiral recognition of α-amino acid derivatives. It is observed that one enantiomer of N-Boc-proline can increase the fluorescence intensity of the binaphthyl fluorophores by over 57-fold, while the other enantiomer can cause only sixfold fluorescence enhancement. Such unusually highly enantioselective response demonstrates that this sensor is potentially useful in the enantioselective recognition of amino acid derivatives. 相似文献
949.
Zhipeng Yu Xiaohua Liu Dr. Lin Zhou Lili Lin Dr. Xiaoming Feng Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(28):5195-5198
Two activations are better than one : The chiral bifunctional guanidine 1 , which features an amino amide backbone, catalyzes the asymmetric Michael addition of a range of substrates and gives products with excellent stereoselectivities. The method also allows the efficient synthesis of optically pure β‐amino acid esters. Both the guanidine group and the NH proton of the amide were important for the dual activation.