Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites

Mass spectrometry (MS) driven metabolomics is a frequently used tool in various areas of life sciences; however, the analysis of polar metabolites is less commonly included. In general, metabolomic analyses lead to the detection of the total amount of all covered metabolites. This is currently a major limitation with respect to metabolites showing high turnover rates, but no changes in their concentration. Such metabolites and pathways could be crucial metabolic nodes (e.g., potential drug targets in cancer metabolism). A stable-isotope tracing capillary electrophoresis–mass spectrometry (CE-MS) metabolomic approach was developed to cover both polar metabolites and isotopologues in a non-targeted way. An in-house developed software enables high throughput processing of complex multidimensional data. The practicability is demonstrated analyzing [U-¹³C]-glucose exposed prostate cancer and non-cancer cells. This CE-MS-driven analytical strategy complements polar metabolite profiles through isotopologue labeling patterns, thereby improving not only the metabolomic coverage, but also the understanding of metabolism.     

TBOR-shaped electro-optic modulator with dual output based on double-layer graphene

We proposed an electro-optic modulator with two-bus one-ring (TBOR) structure to improve the extinction ratio and reduce insert loss. It has a dual output compared with one-bus one-ring structure. In addition, double-layer graphene makes it possible for the modulation in the visible to mid-infrared wavelength range. It shows that this new electro-optic modulator can present two switching states well with low insertion loss, high absorption and high extinction ratio. At $\lambda =1550\text{ nm}$, when the switching states are based on the chemical potential, ${\mu }_{\mathrm{c}}=0.38\text{ eV}$ and ${\mu }_{\mathrm{c}}=0.4\text{ eV}$, the insertion losses of both output ports are less than 2 dB, the absorption of the output port coupled via a micro-ring reaches 45 dB and the extinction ratio reaches 14 dB. When the refractive index of the dielectric material is 4.2, the applied voltage will be less than 1.2 V, thus can be used in low-voltage CMOS technology.     

静止轨道星载差分吸收光谱仪CCD成像系统设计

静止轨道卫星差分吸收光谱仪采用摆扫成像方式对大气进行探测,针对其工作时CCD成像系统信噪比大于1 000、高速探测模式下探测周期小于10min、高分辨率模式下探测周期小于1h的要求,进行CCD成像系统设计.选取CCD47-20作为探测器,设计成像电路实现光谱图像信号的采集和上传.分析了帧叠加和像元合并对时间、空间分辨率的影响.结合帧转移CCD的特点设计了每个位置最后一帧读出时摆镜转动的成像方式,并合理设置了帧叠加数和像元合并数,达到优化成像周期的目的.1s曝光时间条件下,该CCD成像系统的高速、高分辨率模式探测周期分别为515s和3 315s,图像信噪比均大于1 000,污染物观测实验中未出现失帧或重复的现象.该CCD成像系统方案满足静止轨道星载差分吸收光谱仪的探测需求,为静止轨道环境监测仪器设计提供参考.     

微信公众平台在大学生安全教育中的应用

阐述微信公众平台的优势,分析利用微信公众平台开展大学生安全教育的可行性,通过突出信息推送功能、以案讲案、引导大学生参与平台建设等措施发挥微信公众平台载体作用,提出转变传统的安全教育观念、开发信息反馈功能、需要优秀编辑人员等完善微信公众平台运营的建议。     

带有白噪声的Berger方程随机吸引子

考虑带有白噪声的Berger方程解的随机渐近性行为, 用渐近先验估计技术和算子分解方法, 通过引入同构映射构造等价过程, 证明随机吸引子在(H²(U)∩H¹₀(U))×L²(U)中的存在性.     

四元数辛李代数MAD子代数的共轭性

利用四元数理论, 证明了四元数体上辛李代数为实半单李代数, 其极大可交换ad-\!\!可对角化(简称MAD)子代数是相互共轭的.     

图书馆大流通服务模式的特点及对策

随着图书馆服务模式不断升级，新型服务管理模式得到推广与使用，既方便了师生查阅文献资料，也降低了管理人员的工作难度。阐述了大流通服务的概念，分析了大流通服务模式的特点，提出了推进图书馆大流通服务的对策。     

数控仿真中切削面计算的并行化研究

针对高离散精度模型与刀具包围体进行切削计算的情况,由于三维图像重建的计算量大,基于传统CPU实现的数控加工仿真系统不能满足实时性的三维绘制。本文利用GPU的并行性特点,提出并行方式数控仿真切削面显示算法:通过线程并行处理基于MC算法的实体构造模型中体素与刀具包围体的切削计算,根据切削后体素角点信息和边的状态查找建立的构型索引表和交点数目索引表,加速数控仿真切削面的提取,从而提高三维图像的绘制速度,满足实时性显示要求。