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361.
Development of a selective sample clean-up method based on immuno-ultrafiltration for the determination of deoxynivalenol in maize 总被引:1,自引:0,他引:1
Böhm C Cichna-Markl M Brenn-Struckhofova Z Razzazi-Fazeli E 《Journal of chromatography. A》2008,1202(2):111-117
This paper describes the development of a highly selective analytical method for the determination of deoxynivalenol (DON) in maize. The developed method is based on immuno-ultrafiltration (IUF) and is the first application of IUF as a clean-up strategy in food analysis. Quantification of DON was carried out by high-performance liquid chromatography with ultraviolet detection. In contrast to immunoaffinity chromatography, in IUF the antibodies are not bound to a solid support material but used in free form, thus making it possible to avoid the critical immobilisation step. Sample clean-up by IUF proved to be as selective as clean-up using commercially available immunoaffinity columns. The limit of detection (S/N=3) of the analytical method was found to be 74 ng DON/g maize. Repeated analysis of a certified maize reference material on four different days resulted in a mean recovery of 93% with a standard deviation of 10%. 相似文献
362.
Recent work has established a correspondence between the tripartite entanglement measure of three qubits and the macroscopic entropy of the four-dimensional 8-charge STU black hole of supergravity. Here we consider the configurations of intersecting D3-branes, whose wrapping around the six compact dimensions T6 provides the microscopic string-theoretic interpretation of the charges, and associate the three-qubit basis vectors |ABC>, (A, B, C=0 or 1) with the corresponding 8 wrapping cycles. In particular, we relate a well-known fact of quantum information theory, that the most general real three-qubit state can be parameterized by four real numbers and an angle, to a well-known fact of string theory, that the most general STU black hole can be described by four D3-branes intersecting at an angle. 相似文献
363.
Based on the process of the Fresnel diffraction, the possibility of generating a new type of laser beams family by illuminating a curved fork-shaped hologram, with an input hypergeometric-Gaussian beams family of orders n and m is studied in this paper. The theoretical and the numerical results showed that, at the output plane, a high order spiraling Bessel vortex beam is produced. This vortex beam is divergence or non-divergence depending upon the waist position of the input hypergeometric-Gaussian beams, regarding the plane where the curved fork-shaped hologram is situated. Analytical expressions of the amplitude and the intensity distribution of the diffracted wave field are calculated and deduced using the stationary phase method. The actual work generalizes also the Fresnel diffraction study of some subfamilies of the hypergeometric-Gaussian beams family, such as: fundamental Gaussian, hollow Gaussian, modified quadratic Bessel–Gaussian and elegant Laguerre–Gaussian beams. 相似文献
364.
Mohamed El-Sherbiny Eslam K. Fahmy Nada H. Eisa Eman Said Hany A. Elkattawy Hasnaa Ali Ebrahim Nehal M. Elsherbiny Fatma M. Ghoneim 《Molecules (Basel, Switzerland)》2021,26(24)
The development of the field of nanotechnology has revolutionized various aspects in the fields of modern sciences. Nano-medicine is one of the primary fields for the application of nanotechnology techniques. The current study sheds light on the reno-protective impacts of gold nano-particles; nanogold (AuNPs) against 5-flurouracil (5-FU)-induced renal toxicity. Indeed, the use of 5-FU has been associated with kidney injury which greatly curbs its therapeutic application. In the current study, 5-FU injection was associated with a significant escalation in the indices of renal injury, i.e., creatinine and urea. Alongside this, histopathological and ultra-histopathological changes confirmed the onset of renal injury. Both gene and/or protein expression of nuclear factor erythroid 2–related factor 2 (Nrf-2) and downstream antioxidant enzymes revealed consistent paralleled anomalies. AuNPs administration induced a significant renal protection on functional, biochemical, and structural levels. Renal expression of the major sensor of the cellular oxidative status Nrf-2 escalated with a paralleled reduction in the renal expression of the other contributor to this axis, known as Kelch-like ECH-associated protein 1 (Keap-1). On the level of the effector downstream targets, heme oxygenase 1 (HO-1) and gamma-glutamylcysteine synthetase (γ-GCS) AuNPs significantly restored their gene and protein expression. Additionally, combination of AuNPs with 5-FU showed better cytotoxic effect on MCF-7 cells compared to monotreatments. Thus, it can be inferred that AuNPs conferred reno-protective impact against 5-FU with an evident modulatory impact on Nrf-2/Keap-1 and its downstream effectors, HO-1 and γ-GCS, suggesting its potential use in 5-FU regimens to improve its therapeutic outcomes and minimize its underlying nephrotoxicity. 相似文献
365.
Hesham Haffez Shimaa Osman Hassan Y. Ebrahim Zeinab A. Hassan 《Molecules (Basel, Switzerland)》2022,27(1)
In vitro anti-proliferative activity of Pinus palustris extract and its purified abietic acid was assessed against different human cancer cell lines (HepG-2, MCF-7 and HCT-116) compared to normal WI-38 cell line. Abietic acid showed more promising IC50 values against MCF-7 cells than pine extract (0.06 µg/mL and 0.11 µM, respectively), with insignificant cytotoxicity toward normal fibroblast WI-38 cells. Abietic acid triggered both G2/M cell arrest and subG0-G1 subpopulation in MCF-7, compared to SubG0-G1 subpopulation arrest only for the extract. It also induced overexpression of key apoptotic genes (Fas, FasL, Casp3, Casp8, Cyt-C and Bax) and downregulation of both proliferation (VEGF, IGFR1, TGF-β) and oncogenic (C-myc and NF-κB) genes. Additionally, abietic acid induced overexpression of cytochrome-C protein. Furthermore, it increased levels of total antioxidants to diminish carcinogenesis and chemotherapy resistance. P. palustris is a valuable source of active abietic acid, an antiproliferative agent to MCF-7 cells through induction of apoptosis with promising future anticancer agency in breast cancer therapy. 相似文献
366.
Serhii Shyshkanov Tu N. Nguyen Fatmah Mish Ebrahim Kyriakos C. Stylianou Paul J. Dyson 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(16):5425-5429
Frustrated Lewis pairs (FLPs) consist of sterically hindered Lewis acids and Lewis bases, which provide high catalytic activity towards non‐metal‐mediated activation of “inert” small molecules, including CO2 among others. One critical issue of homogeneous FLPs, however, is their instability upon recycling, leading to catalytic deactivation. Herein, we provide a solution to this issue by incorporating a bulky Lewis acid‐functionalized ligand into a water‐tolerant metal‐organic framework (MOF), named SION‐105 , and employing Lewis basic diamine substrates for the in situ formation of FLPs within the MOF. Using CO2 as a C1‐feedstock, this combination allows for the efficient transformation of a variety of diamine substrates into benzimidazoles. SION‐105 can be easily recycled by washing with MeOH and reused multiple times without losing its identity and catalytic activity, highlighting the advantage of the MOF approach in FLP chemistry. 相似文献
367.
Deependra M. Shakya Otega A. Ejegbavwo Thayalan Rajeshkumar Sanjaya D. Senanayake Amy J. Brandt Sharfa Farzandh Narayan Acharya Amani M. Ebrahim Anatoly I. Frenkel Ning Rui Gregory L. Tate John R. Monnier Konstantinos D. Vogiatzis Natalia B. Shustova Donna A. Chen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(46):16685-16689
We report the first study of a gas‐phase reaction catalyzed by highly dispersed sites at the metal nodes of a crystalline metal–organic framework (MOF). Specifically, CuRhBTC (BTC3?=benzenetricarboxylate) exhibited hydrogenation activity, while other isostructural monometallic and bimetallic MOFs did not. Our multi‐technique characterization identifies the oxidation state of Rh in CuRhBTC as +2, which is a Rh oxidation state that has not previously been observed for crystalline MOF metal nodes. These Rh2+ sites are active for the catalytic hydrogenation of propylene to propane at room temperature, and the MOF structure stabilizes the Rh2+ oxidation state under reaction conditions. Density functional theory calculations suggest a mechanism in which hydrogen dissociation and propylene adsorption occur at the Rh2+ sites. The ability to tailor the geometry and ensemble size of the metal nodes in MOFs allows for unprecedented control of the active sites and could lead to significant advances in rational catalyst design. 相似文献
368.
Toghyani Somayeh Afshari Ebrahim Baniasadi Ehsan 《Journal of Thermal Analysis and Calorimetry》2019,135(3):1911-1919
Journal of Thermal Analysis and Calorimetry - The performance of a proton exchange membrane electrolyzer cell directly depends on the arrangement of flow field in bipolar plates (BPs). The design... 相似文献
369.
Blessing O. Umeokoli Weaam Ebrahim Mona El-Neketi Werner E. G. Müller Rainer Kalscheuer Wenhan Lin 《Natural product research》2019,33(15):2215-2222
A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1?D and 2?D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3?µM whereas compound 7 showed selective anti-bacterial activity against different S. aureus and E. faecium bacterial strains with MIC value of 25?µg/ml. 相似文献
370.
A new one-pot procedure for the efficient synthesis of novel 3,4-dihydrocoumarin derivatives using commercially available substituted 2-hydroxybenzaldehydes, Meldrum's acid, and isocyanides by a three-component condensation reaction in dichloromethane at room temperature without using any catalysts and activation was developed. 相似文献