Investigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification

Ulcerative colitis is a chronic inflammatory bowel disorder that is hard to cure once diagnosed. Bisdemethoxycurcumin has shown positive effects on inflammatory diseases. However, the underlying bioactive interaction between bisdemethoxycurcumin and ulcerative colitis is unclear. The objective of this study was to determine the core target and potential mechanism of action of bisdemethoxycurcumin as a therapy for ulcerative colitis. The public databases were used to identify potential targets for bisdemethoxycurcumin and ulcerative colitis. To investigate the potential mechanisms, the protein-protein interaction network, gene ontology analysis, and Kyoto encyclopedia of genes and genomes analysis have been carried out. Subsequently, experimental verification was conducted to confirm the findings. A total of 132 intersecting genes of bisdemethoxycurcumin, as well as ulcerative coli-tis-related targets, were obtained. SRC, EGFR, AKT1, and PIK3R1 were the targets of highest potential, and the PI3K/Akt and MAPK pathways may be essential for the treatment of ulcerative colitis by bisdemethoxycurcumin. Molecular docking demonstrated that bisdemethoxycurcumin combined well with SRC, EGFR, PIK3R1, and AKT1. Moreover, the in vitro experiments suggested that bisdemethoxycurcumin might reduce LPS-induced pro-inflammatory cytokines levels in RAW264.7 cells by suppressing PI3K/Akt and MAPK pathways. Our study provided a comprehensive overview of the potential targets and molecular mechanism of bisdemethoxycurcumin against ulcerative colitis. Furthermore, it also provided a theoretical basis for the clinical treatment of ulcerative colitis, as well as compelling evidence for further study on the mechanism of bisdemethoxycurcumin in the treatment of ulcerative colitis.     

自组装多肽探针在磁共振成像中的应用

磁共振成像(MRI)是一种强大的非侵入式生物医学诊断技术. 临床上, MRI需要借助造影剂来提高成像质量, 从而提高诊断的准确性. 由于具有优越的信号放大能力和生物相容性, 自组装多肽探针可负载特定的MRI分子, 通过酶促自组装过程实现肿瘤靶向和特异性富集, 增强肿瘤病灶区MRI信号, 从而进一步提高MRI的准确性和灵敏度. 本综述总结了近年来多肽自组装探针在不同MRI模式( ¹H MRI, ¹⁹F MRI和双自旋核MRI)下的最新进展, 并展望了这类新型探针在MRI领域的应用前景.     

Fluorination of Terminal Groups Promoting Electron Transfer in Small Molecular Acceptors of Bulk Heterojunction Films

The fluorination strategy is one of the most efficient and popular molecular modification methods to develop new materials for organic photovoltaic (OPV) cells. For OPV materials, it is a broad agreement that fluorination can reduce the energy level and change the morphology of active layers. To explore the effect of fluorination on small molecule acceptors, we selected two non-fullerene acceptors (NFA) based bulk heterojunction (BHJ) films, involving PM6:Y6 and PM6:Y5 as model systems. The electron mobilities of the PM6:Y5 and PM6:Y6 BHJ films are 5.76 × 10⁻⁷ cm²V⁻¹s⁻¹ and 5.02 × 10⁻⁵ cm²V⁻¹s⁻¹ from the space-charge-limited current (SCLC) measurements. Through molecular dynamics (MD) simulation, it is observed that halogen bonds can be formed between Y6 dimers, which can provide external channels for electron carrier transfer. Meanwhile, the “A-to-A” type J-aggregates are more likely to be generated between Y6 molecules, and the π–π stacking can be also enhanced, thus increasing the charge transfer rate and electron mobility between Y6 molecules.     

Reinvestigating the Preferential Enrichment of DL-Arginine Fumarate: New Thoughts on the Mechanism of This Far from Equilibrium Crystallization Phenomenon

Preferential enrichment (PE) is a crystallization process, starting from either a racemic of slightly enantio-enriched solution (ca. +5%) that results in a high enantiomeric excess in the liquid phase (>+90%ee) and a slight opposite excess in the deposited crystals (−2 to −5%ee). The mechanism(s) of this symmetry-breaking phenomenon is (are) still a matter of debate since it eludes rationalization by phase diagram formalism. In this publication, we thoroughly reinvestigate the PE phenomenon of arginine fumarate by using a new approach: the process is monitored by introducing isotopically labeled arginine enantiomers into the crystallization medium to better understand the mass exchanges during crystallization. These experiments are supported by chiral HPLC-MS/MS. This study permits re-evaluating the criteria that were thought mandatory to perform PE. In particular, we show that PE occurs by a continuous exchange between the solution and the crystals and does not require the occurrence of a solvent-mediated solid–solid phase transition.     

频率搅拌嵌套混响室场分布的统计特性

为明确频率搅拌方式下嵌套混响室内的场分布,在混响室电磁统计特性的基础上,对嵌套小室内外的场分布进行了理论研究,重点对小混响室开窗大小对场分布的影响进行了分析。当窗口为电大尺寸时,小混响室内外均服从瑞利分布;为电小尺寸时,参考车-车链路通信的统计特性,小混响室内部应满足双瑞利分布。在某大型混响室内,借助矢量网络分析仪,通过测试收、发天线间的散射参数S21,实现了样本数据的快速采集,并将样本数据与理论分布模型进行了拟合优度检验（KS检验）,检验结果证明了假设分布的正确性。     

0.22 THz折叠波导行波管电子光学系统设计与实验研究

设计了一套0.22 THz折叠波导行波管电子光学系统,详细介绍了电子枪和周期永磁聚焦系统的设计过程,在电子枪电子束束腰与磁系统不匹配情况下,对磁场过渡区进行了优化设计,以此为基础利用磁场仿真软件对磁场进行模拟和优化,并把磁场位形代入电磁仿真软件进行电子束传输仿真,优化后的电子光学系统发射束流10 mA,阴极电压15 kV,束流通过率96%。通过实验验证,流通管束流通过率93%,高频样管束流通过率94%,与设计相符。高频样管实现连续波运行,功率大于0.4 W,3 dB带宽大于12 GHz。     

AUFS格式在无网格方法中的应用

将计算量小,激波分辨率高的AUFS (artificially upstream flux vector splitting) 格式应用于无网格方法. 所发展算法基于多项式基函数最小二乘无网格方法,采用线性基函数曲面拟合及AUFS 格式计算各离散点的空间导数,应用四阶Runge-Kutta 法进行时间显式推进. 为验证算法健壮性、精度以及计算效率,对Riemann 问题、超音速平面流动,以及不同攻角NACA0012 翼型跨音速流场进行了数值模拟,其结果同采用HLLC (Harten-Lax-van Leer-contact) 格式的无网格方法以及文献报道结果吻合较好,并且计算量较形式简单HLLC 格式减少约15%.     

快速z箍缩装置的预脉冲分析

输出参数为500 kV/400 kA/100 ns的快速z箍缩(z-p inch)装置由M arx发生器、脉冲形成线、充气型V/N主开关、传输线及负载组成。z箍缩负载分别采用氖气喷气负载及金属单丝负载。为了判断主放电时负载的初始状态,该文建立了z箍缩装置的充电等效电路模型,并借助P sp ice电路模拟软件计算了形成线充电期间在负载上获得的预脉冲波形。通过分析可知:p d值为1~10 Pa.m左右的氖气负载,在装置预脉冲电压的作用下将被击穿;而直径为20μm、长度为1 cm的A l(铝)或W(钨)单丝负载,装置预脉冲电流将不能使之汽化。     

青藏高原过度放牧与草地退化治理的演化博弈

为探讨青藏高原过度放牧与草地退化的治理机制以及治理成本变化、不同治理措施对地方政府监管和牧民放牧行为的影响,本研究构建了涉及地方政府与牧民双方的治理演化博弈模型。研究发现：满足一定条件时地方政府监管有效,此时牧民适度放牧,人地关系和谐。地方政府监管的固定成本、可变成本和不监管的压力均能促进地方政府选择监管策略。地方政府的监管措施主要有事前约束和事后惩罚两种,这两种治理措施均能有效约束牧民的过度放牧行为,促进草地退化治理。本研究将地方政府监管措施和农牧民的放牧行为纳入到博弈论的框架中,揭示出青藏高原草地退化治理的多主体互动模式和不同情景下的治理效果,相关结论能够为草地退化治理和青藏高原生态安全屏障建设政策的制定提供启示。     

大连民族学院学生思想状况调查与对策分析

依据问卷调查和学生思想政治教育工作实际,分析了当前大学生的思想特点,对增强大学生思想政治教育的针对性和实效性,促进各民族学生全面发展进行了若干思考并提出对策。