Anti-neuraminidase activity of chemical constituents of Balanophora involucrata

Balanophora involucrata J. D. Hooker has been known to possess potential anti-inflammatory and antibacterial activities; however, its antiviral activity has not been evaluated so far. In order to find new neuraminidase inhibitors (NAIs), the neuraminidase (NA) inhibition activity of different B. involucrata extracts was evaluated. In this study, an in vitro NA inhibition assay was performed to identify which extract of B. involucrata exhibits (maximal) inhibitory activity against NA. Ultra high performance liquid chromatography/quadrupole time-of-flight–tandem mass spectroscopy (MS/MS) and molecular docking techniques were used to identify the specific compounds responsible for the anti-influenza activity of the extract, and to explore the potential natural NAIs. The ethyl acetate extract of B. involucrata exhibited significant inhibitory activity against NA with 50% inhibitory concentration (IC₅₀) value of 159.5 μg/mL. Twenty compounds were identified according to the MS/MS spectra; among them two compounds (quercitrin and phloridzin) showed obvious inhibitory activity against NA, with IC₅₀ of 311.76 and 347.32 μmol/L, respectively. This study suggested that B. involucrata can be a potential natural source of NAIs and may be useful in the fight against ferocious influenza viruses.     

Solving nonnegative sparsity-constrained optimization via DC quadratic-piecewise-linear approximations

Journal of Global Optimization - In this paper, we propose a novel algorithm that is based on quadratic-piecewise-linear approximations of DC functions to solve nonnegative sparsity-constrained...     

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介绍了AWM720P1新型气体流量传感器的工作原理、性能、特点．针对呼吸机的工作特点，分析了IPPV的流速模型、流速的测量方法、传感器的校正数据处理方法．     

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该系统严格遵照国家干部经济责任审计的有关准则与规定，能够对企事业单位、行政单位等不同部门各个层次的领导干部，从内控制度、管理、经营、财务等多方面、多角度、全方位地进行跟踪审计，客观公正、实事求是地对有关报表数据进行科学分析，恰如其分地认定干部实绩和经济责任。