要素贡献与西藏经济跨越式发展的相关性研究

西藏作为我国西部的欠发达地区,其显著特征表现为人均GDP较低。为了实现我国经济的平衡发展,缩小区域差距,西藏必须利用后发优势,提高经济产出的数量与质量,实现经济的跨越式发展。经济的产出数量与质量不仅取决于传统投入要素的数量与质量,还取决于其它投入要素的优化程度,主要包括产业结构的优化程度、经济制度与经济发展状况的匹配度。鉴于此,文章从以上三个方面来分析西藏经济跨越式发展的要素贡献,以利于要素投入的高效率与要素结构的合理化,保证西藏经济的跨越式发展与可持续发展。     

青龙本地山羊随机扩增多态DNA与体重体尺相关性研究

利用９ 种随机引物研究了青龙本地山羊的随机扩增多态ＤＮＡ,并利用ＳＰＳＳ程序对多态标记进行了方差分析。结果表明,青龙本地山羊基因组ＤＮＡ 多态频率为４８．６５％ 。多态标记Ｋ０９Ｂ、Ｐ１４Ｄ和Ｑ１４Ｄ及其互作效应与体重和体尺有显著相关     

个人语码转换的动机研究

在言语交际中语码转换现象非常普遍。对语码转换的动机研究更是涵盖了社会语言学、语用学、心理学等各个学科角度。基于前人的理论研究成果,本文认为个人语码转换的深层动机受控于社会规则和话语主体意识等二元因素。     

影响磁头超薄气膜飞行稳态特性因素的数值分析

利用有限差分原理对修正后的气体雷诺方程进行离散,并以剪切流为迭代主项求解获得了超薄气膜润滑轴承的压力分布.在此基础上,通过改变磁头初始工作条件,如气膜特征高度、初始俯仰角、磁盘旋转速度,分别计算得到了气膜轴承在稳态下的飞行特性参数,包括气浮力、气浮力转矩、最大气浮力、最小气浮力等.文中还详细分析了这些初始工作条件对稳态下磁头飞行特性参数的影响.计算结果表明:随着气膜特征高度的降低和初始俯仰角的减小,气体轴承刚度增大;气膜特征高度不变时转速变化对特性参数的影响与俯仰角不变时转速对特性参数的影响具有相同的变化趋势.     

基于长白山臭冷杉胶合板强度的水性异氰酸酯胶黏剂配比

用水性异氰酸酯胶黏剂压制长白山臭冷杉胶合板,通过检测胶合板的胶合强度,分析聚乙烯醇(PVA)质量分数、甲苯二异氰酸酯(TDI)质量分数、乳化剂用量等因素对水性异氰酸酯胶黏剂胶合性能的影响.利用正交试验方差分析得出各影响因素间的主次关系为TDI质量分数PVA质量分数乳化剂质量分数.当PVA质量分数为10%、TDI质量分数为5%、乳化剂质量分数为30%时,水性异氰酸酯胶黏剂的胶合性能最好,胶合强度达到了0.79 MPa.     

“Click handle”-modified 2′-deoxy-2′-fluoroarabino nucleic acid as a synthetic genetic polymer capable of post-polymerization functionalization

The functions of natural nucleic acids such as DNA and RNA have transcended genetic information carriers and now encompass affinity reagents, molecular catalysts, nanostructures, data storage, and many others. However, the vulnerability of natural nucleic acids to nuclease degradation and the lack of chemical functionality have imposed a significant constraint on their ever-expanding applications. Herein, we report the synthesis and polymerase recognition of a 5-(octa-1,7-diynyl)uracil 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) triphosphate. The DNA-templated, polymerase-mediated primer extension using this “click handle”-modified FANA (cmFANA) triphosphate and other FANA nucleotide triphosphates consisting of canonical nucleobases efficiently generated full-length products. The resulting cmFANA polymers exhibited excellent nuclease resistance and the ability to undergo efficient click conjugation with azide-functionalized molecules, thereby becoming a promising platform for serving as a programmable and evolvable synthetic genetic polymer capable of post-polymerization functionalization.

Polymerase-mediated incorporation of a “click handle”-modified fluoroarabinonucleic acid (cmFANA) triphosphate produces a new class of nuclease-resistant, evolvable genetic polymers that can be functionalized with azide-containing molecules.     

地下圆形空洞地质雷达成像机理

由于地理因素和历史等原因,城市地下圆形空洞“多”“密”“乱”的状况越来越严重,地质雷达圆形空洞扫描图像解析并不明确。基于地质雷达扫描探测全过程,将雷达紧贴地面扫描地下圆形空洞的全过程图像细分为三个阶段,建立各阶段水平距离与回波延时之间的关系,系统分析不同埋深,不同半径条件下圆形空洞地质雷达扫描图像的变化情况,结合探测实例实现地下圆形空洞地质雷达成像机理的科学解释。总结出地下圆形空洞雷达扫描图像对称轴左侧为单调递减的连续凹函数,厚度由不断增大至稳定;对称轴右侧为单调递增的连续凹函数,厚度由稳定至不断减小;随着埋深与半径增大,曲线曲率减小,曲线图像趋于缓和,曲线的特征体现出张开弧度增大的趋势。     

调和NA群上的Hardy不确定原理

首先介绍了调和NA群的基本结构和球函数的性质.其次基于调和NA群上的Helgason-Fourier变换及相应于Laplace-Beltrami算子的热核,在NA群上建立了Hardy不确定原理.所得结论推广了Thangavelu（2002年）的部分结果.     

一类高维Laplace方程的拟周期解

本文利用 KAM 理论,证明了一类带有常位势 m(m>2) 以及 Fourier 乘子Mζ的高维Laplace 方程△u (m Mζ)u u3=0,在周期边值条件下拟周期解的存在性.     

Established Liposome-Coated IMB16-4 Polymeric Nanoparticles (LNPs) for Increasing Cellular Uptake and Anti-Fibrotic Effects In Vitro

As a global health problem, liver fibrosis still does not have approved treatment. It was proved that N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4) has anti-hepatic fibrosis activity. However, IMB16-4 displays poor water solubility and poor bioavailability. We are devoted to developing biodegraded liposome-coated polymeric nanoparticles (LNPs) as IMB16-4 delivery systems for improving aqueous solubility, cellular uptake, and anti-fibrotic effects. The physical states of IMB16-4−LNPs were analyzed using a transmission electron microscope (TEM), high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimeter (DSC). The results show that IMB16-4−LNPs increased the drug loading compared to liposomes and enhanced cellular uptake behavior compared with IMB16-4−NPs. In addition, IMB16-4−LNPs could repress the expression of hepatic fibrogenesis-associated proteins, indicating that IMB16-4−LNPs exhibited evident anti-fibrotic effects.