面向并行设计的局部特征识别技术研究

为支持在并行设计过程中设计特征模型到加工特征模型的逐步转换，提出了局部特征识别的方法．在并行设计中，设计特征模型和加工特征模型通过面名历史图共享零件的实体模型，设计特征的变动通过局部特征识别自动地转换为相应的加工特征．局部特征识别是由基于最小条件子图特征识别方法改进来的，它以零件的局部区域为识别对象，通过搜索匹配局部区域构成的边界模式，识别出该局部区域中所包含的加工特征．局部特征识别方法的特点是只对设计中发生变动的区域进行识别．     

A novel retinoblastoma therapy from genomic and epigenetic analyses

Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low; RB1 was the only known cancer gene mutated. We then evaluated the role of RB1 in genome stability and considered non-genetic mechanisms of cancer pathway deregulation. For example, the proto-oncogene SYK is upregulated in retinoblastoma and is required for tumour cell survival. Targeting SYK with a small-molecule inhibitor induced retinoblastoma tumour cell death in vitro and in vivo. Thus, retinoblastomas may develop quickly as a result of the epigenetic deregulation of key cancer pathways as a direct or indirect result of RB1 loss.