癌症相关促凋亡蛋白Par-4的信号转导途径预测研究

利用支持向量机(SVM)技术构建Par-4关联的蛋白质相互作用网络,预测出与Par-4有相互作用的蛋白质82个;这些蛋白质按照功能划分为8大类,主要包括:蛋白激酶、泛素化蛋白酶、死亡受体相关因子、与细胞周期或DNA复制相关蛋白质、调节蛋白质、与疾病相关蛋白质、具有特定结构域结合蛋白质和其他蛋白质等。结合文献挖掘和数据库检索信息,推断出了Par-4的2条可能新的信号转导途径。首次预测到Par-4与一大类泛素化蛋白有密切的关系。研究发现,Par-4与多种蛋白质具有复杂的相互作用,并且,在多个细胞凋亡途径中扮演了重要角色。     

高增益自由电子激光饱和状态分析的一种统计物理方法

讨论近年出现的分析自由电子激光系统饱和状态性质的一种统计物理方法.对于自由电子激光系统激光增益达到饱和时的主要物理参数所满足的方程作了推演,进而基于统计物理方法利用Lynden-Bell熵函数和Mathematica程序进行了相关的数值计算和分析.为了对这一方法作验证和对比,通过直接数值模拟的方法分析了暖电子束入射情形下系统光强、聚束因子和粒子相空间分布的性质以及它们之间的对应关系,比较显示数值模拟结果与统计物理方法的相应结果一致.     

采用定性坐标的位置表达及主方向关系推理

针对现有的位置关系表达模型均面向点对象,提出了定性直角坐标的概念,基于此概念提出了一种平面区域对象位置关系表达模型,该模型通过记录主对象与参考对象的定性位置区域的交集是否为空,由此构造位置矩阵来表达区域对象间的位置关系,从而较好地反映了对象的形状及对象间的空间布局,可有效地表达区域对象间的位置关系,并通过定性坐标将方向和距离关系有机地结合在一起形成统一的表达和推理模型.为了提高主方向关系推理的精度,基于该模型又提出了一个主方向关系推理算法,并对其正确性进行了验证.理论分析和实例验证的结果表明,该算法降低了推理的不确定性,提高了推理的精度.     

[Review] Dark Energy

We review the problem of dark energy, including a survey of theoretical models and some aspects of numerical studies.     

Excimer formation dynamics in the isolated tetracene dimer

The understanding of excimer formation and its interplay with the singlet-correlated triplet pair state ¹(TT) is of high significance for the development of efficient organic electronics. Here, we study the photoinduced dynamics of the tetracene dimer in the gas phase by time-resolved photoionisation and photoion imaging experiments as well as nonadiabatic dynamics simulations in order to obtain mechanistic insight into the excimer formation dynamics. The experiments are performed using a picosecond laser system for excitation into the S₂ state and reveal a biexponential time dependence. The time constants, obtained as a function of excess energy, lie in the range between ≈10 ps and 100 ps and are assigned to the relaxation of the excimer on the S₁ surface and to its deactivation to the ground state. Simulations of the quantum-classical photodynamics are carried out in the frame of the semi-empirical CISD and TD-lc-DFTB methods. Both theoretical approaches reveal a dominating relaxation pathway that is characterised by the formation of a perfectly stacked excimer. TD-lc-DFTB simulations have also uncovered a second relaxation channel into a less stable dimer conformation in the S₁ state. Both methods have consistently shown that the electronic and geometric relaxation to the excimer state is completed in less than 10 ps. The inclusion of doubly excited states in the CISD dynamics and their diabatisation further allowed to observe a transient population of the ¹(TT) state, which, however, gets depopulated on a timescale of 8 ps, leading finally to the trapping in the excimer minimum.

The understanding of excimer formation and its interplay with the singlet-correlated triplet pair state ¹(TT) is of high significance for the development of efficient organic electronics.     

二维层状GaTe的晶体结构研究

采用布里奇曼法生长出了化合物半导体GaTe,并对其晶体结构进行研究.利用X射线衍射仪对GaTe粉末和块体试样分别进行测试,确定了其晶体结构.采用透射电子显微镜对二维薄膜GaTe及二维纳米层GaTe进行观测,并结合晶体定向仪对GaTe解理面进行了定向分析.结果表明,二维薄膜GaTe及二维纳米层GaTe分别对应单斜和六方两种不同的晶体结构,并对应不同的解理面.     

Nonlocal symmetry,optimal systems,and explicit solutions of the mKdV equation

The nonlocal symmetry of the mKdV equation is obtained from the known Lax pair; it is successfully localized to Lie point symmetries in the enlarged space by introducing suitable auxiliary dependent variables. For the closed prolongation of the nonlocal symmetry, the details of the construction for a one-dimensional optimal system are presented. Furthermore, using the associated vector fields of the obtained symmetry, we give the reductions by the one-dimensional sub-algebras and the explicit analytic interaction solutions between cnoidal waves and kink solitary waves, which provide a way to study the interactions among these types of ocean waves. For some of the interesting solutions, the figures are given to show their properties.     

商用车车身底部尘土污染分析及优化

针对某商用车发动机舱冷却气流导致严重的扬尘问题进行分析研究,通过风扇不同转速下的车底扬尘模拟实验来确定导致扬尘的最低转速,对车底风速进行测试,确定扬尘风速的临界点。通过计算流体动力学仿真,在保证散热性能的前提下,比较了延长护风圈和加导流板两种方案,发现延长50 mm的护风圈和增加10°的导流板扬尘效果最为显著。在两者共同作用下,车底风速降至扬尘临界点以下以及扬尘颗粒数减少75%。通过实车道路测试验证优化方案效果。     

高精度V棱镜折射仪光机结构设计

针对传统V棱镜折射仪采用光学度盘,目视对准方式无法满足现代光学玻璃生产线以及高精度折射率测量的需求。提出一种新型的高精度基于CCD 机器视觉对准的V棱镜折射仪的总体设计方案,并对准直光管、传动机构、锁紧和微调机构以及轴角编码测角机构等主要组成部分进行了光机结构设计。在考虑空气折射率影响因素的修正公式的基础上,分析了仪器的检测误差。实验结果表明:其折射率检测精度可达 310-6,满足了高精度V棱镜折射仪的技术指标要求。     

莫桑比克摩根石的谱学特征研究

近几年摩根石凭借它独特的色彩悄然兴起。采用常规仪器测试、激光剥蚀等离子质谱(LA-ICP-MS)、紫外-可见吸收光谱(UV)、红外光谱(IR)和拉曼光谱(Raman),对产自莫桑比克的摩根石基本性质、化学成分特征、谱学性质进行了较为详细的分析。紫外-可见光谱获得样品主波长、饱和度、明度等相关颜色参数;成分测试显示样品摩根石中Li,Rb,Cs,Mn等含量较高,计算所得到的晶体化学式为Be_3.2090Al_2.0757Li_0.425Si_5.664O₁₈(Na_0.1420Cs_0.1316);红外光谱显示,摩根石的结构振动区主要在指纹区400～1 200 cm-1,其中900～1 200 cm-1为Si—O—Si环的振动区,550～900 cm-1为Be—O振动区,而450~530 cm-1为Al—O振动区。由于摩根石中的Cs元素的含量较高,而Cs为原子序数较高的元素,其存在可能令Si—O—Si环振动谱峰向低频位移。拉曼光谱显示1 065 cm-1为Si—O非桥氧伸缩面内振动,1 000 cm-1左右为Be—O的非桥氧伸缩面外振动,685 cm-1为Si—O—Si的变形面内振动,400 cm-1为O—Be—O的面外弯曲振动,在390 cm-1处为Al—O的面外变形振动,在320 cm-1处为Al—O的面外弯曲振动。