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排序方式: 共有200条查询结果,搜索用时 62 毫秒
31.
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Wu X Northcott PA Dubuc A Dupuy AJ Shih DJ Witt H Croul S Bouffet E Fults DW Eberhart CG Garzia L Van Meter T Zagzag D Jabado N Schwartzentruber J Majewski J Scheetz TE Pfister SM Korshunov A Li XN Scherer SW Cho YJ Akagi K MacDonald TJ Koster J McCabe MG Sarver AL Collins VP Weiss WA Largaespada DA Collier LS Taylor MD 《Nature》2012,482(7386):529-533
Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord. Dissemination, a marker of poor prognosis, is found in up to 40% of children at diagnosis and in most children at the time of recurrence. Affected children therefore are treated with radiation to the entire developing brain and spinal cord, followed by high-dose chemotherapy, with the ensuing deleterious effects on the developing nervous system. The mechanisms of dissemination through the cerebrospinal fluid are poorly studied, and medulloblastoma metastases have been assumed to be biologically similar to the primary tumour. Here we show that in both mouse and human medulloblastoma, the metastases from an individual are extremely similar to each other but are divergent from the matched primary tumour. Clonal genetic events in the metastases can be demonstrated in a restricted subclone of the primary tumour, suggesting that only rare cells within the primary tumour have the ability to metastasize. Failure to account for the bicompartmental nature of metastatic medulloblastoma could be a major barrier to the development of effective targeted therapies. 相似文献
33.
Gael M. Martin Brendan P. M. McCabe David T. Frazier Worapree Maneesoonthorn Christian P. Robert 《Journal of computational and graphical statistics》2013,22(3):508-522
A computationally simple approach to inference in state space models is proposed, using approximate Bayesian computation (ABC). ABC avoids evaluation of an intractable likelihood by matching summary statistics for the observed data with statistics computed from data simulated from the true process, based on parameter draws from the prior. Draws that produce a “match” between observed and simulated summaries are retained, and used to estimate the inaccessible posterior. With no reduction to a low-dimensional set ofsufficient statistics being possible in the state space setting, we define the summaries as the maximum of an auxiliary likelihood function, and thereby exploit the asymptotic sufficiency of this estimator for the auxiliary parameter vector. We derive conditions under which this approach—including a computationally efficient version based on the auxiliary score—achieves Bayesian consistency. To reduce the well-documented inaccuracy of ABC in multiparameter settings, we propose the separate treatment of each parameter dimension using an integrated likelihood technique. Three stochastic volatility models for which exact Bayesian inference is either computationally challenging, or infeasible, are used for illustration. We demonstrate that our approach compares favorably against an extensive set of approximate and exact comparators. An empirical illustration completes the article. Supplementary materials for this article are available online. 相似文献
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Striolo A McCabe C Cummings PT Chan ER Glotzer SC 《The journal of physical chemistry. B》2007,111(42):12248-12256
Polyhedral oligomeric silsesquioxanes (POSS) are multifunctional molecules that can be employed as building blocks to develop nanocomposite materials whose mechanical properties often improve upon those of traditional polymeric materials. We report here molecular simulation results for the effective potential of mean force between octamethyl POSS monomers and between POSS monomers in which one methyl group has been substituted by a linear alkane chain of nine carbon atoms in liquid normal hexane at 300 and 400 K. The results are discussed and compared to available data for the effective interactions between octamethyl POSS monomers in normal hexadecane. Our results show that the effective short-ranged POSS-POSS attraction is significantly weaker in hexane than it is in hexadecane, perhaps explaining why normal hexane is often the solvent of choice for the preparation of POSS-containing materials. Additionally, we provide results for the radial distribution functions between selected sites in the POSS monomers that can be used both to understand the association between POSS monomers in solution and to parametrize coarse-grained simulation models. Such models will be used to study the formation of POSS-containing supramolecular structures such as lamellae or micelles that are currently not accessible by atomistic simulation and can be compared to experimental observations. 相似文献
36.
Pamela L. Broaddus-Lawrence Kathleen Treole Robert B. McCabe Rose L. Allen Louise Toppin 《Journal of voice》2000,14(1):58-71
The purpose of the present study was to determine the effects of vocal hygiene education on the vocal hygiene behaviors and perceptual vocal characteristics of untrained singers. Eleven adult untrained singers served as subjects. They attended four 1-hour class sessions on vocal hygiene, including anatomy and physiology of the phonatory mechanism, vocally abusive behaviors, voice disorders commonly seen in singers, and measures to prevent voice disorders. Pre- and postinstruction surveys were used to record subjects' vocal abuses and their perceptions of their speaking and singing voice. They also rated their perceived value of vocal hygiene education. Results revealed minimal changes in vocal hygiene behaviors and perceptual voice characteristics. The subjects did report a high degree of benefit and learning, however. 相似文献
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Formulas for calculating Legendre functions and associated Legendre functions of the first kind of complex degree using an Ermakov—Lewis invariant are presented. These formulas are straight-forward to implement numerically and are motivated by the lack of computational routines in standard university tools like those of MatLab and Maple. Angular waves propagating in opposite directions are also obtained. The results are particularly useful in complex angular momentum theories and nearside/farside analysis of spin-dependent angular scattering from central potentials. 相似文献
39.
Marko Knezevic Rodney J. McCabe Ricardo A. Lebensohn Carlos N. Tomé Cheng Liu Manuel L. Lovato Bogdan Mihaila 《Journal of the mechanics and physics of solids》2013
We present an implementation of the viscoplastic self-consistent (VPSC) polycrystalline model in an implicit finite element (FE) framework, which accounts for a dislocation-based hardening law for multiple slip and twinning modes at the micro-scale grain level. The model is applied to simulate the macro-scale mechanical response of a highly anisotropic low-symmetry (orthorhombic) crystal structure. In this approach, a finite element integration point represents a polycrystalline material point and the meso-scale mechanical response is obtained by the mean-field VPSC homogenization scheme. We demonstrate the accuracy of the FE-VPSC model by analyzing the mechanical response and microstructure evolution of α-uranium samples under simple compression/tension and four-point bending tests. Predictions of the FE-VPSC simulations compare favorably with experimental measurements of geometrical changes and microstructure evolution. Specifically, the model captures accurately the tension–compression asymmetry of the material associated with twinning, as well as the rigidity of the material response along the hard-to-deform crystallographic orientations. 相似文献
40.
Padraic S. Nagle Amila Kahved?i? Thomas McCabe Isabel Rozas 《Structural chemistry》2012,23(2):315-323
We present the crystal structures of the chloride salts of the mono-guanidinium 1 (–CH2CH2– linker) and the bis-isouronium 2 (–O– linker) that have been resolved by us indicating that these compounds are diprotonated in the solid state as informed
by the counterions positions. To determine the pK
a values of these compounds as well as those of their analogues 3 (mono-2-aminoimidazolinium with a –CH2CH2– linker) and 4 (mono-guanidinium with a –O– linker), the corresponding UV–Vis titrations were carried out. Thus, in aqueous solution compounds
1, 3 and 4 were present as mono-cationic species while derivative 2 was a bis-cation. 相似文献