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71.
Yanni Lv Xianpeng Shi Jia Fu Qianqian Jia Yuanyuan Lin Hongying Wang Xin Yang Shengli Han 《Biomedical chromatography : BMC》2019,33(9)
Marsdenia tenacissima, or Tongguanteng in Chinese, is a traditional Chinese herb and has a broad application in clinical practice for its pharmacological effects of treating asthma, pneumonia, tonsillitis, pharyngitis tumors, etc. However, few studies have reported the screening of the active components of this medicine for tumor therapy. In this work, a two‐dimensional analytical system was developed to screen antagonists of epidermal growth factor receptor (EGFR) from M. tenacissima. A fraction was retained on the EGFR cell membrane chromatography (CMC) column, separated and identified as tenacissoside G (TG), tenacissoside H (TH) and tenacissoside I (TI) by two‐dimensional HPLC–IT–TOF–MS. Molecular docking and 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay were carried out to assess the activity of TS (including TG, TH and TI). Molecular docking results showed that the binding mode of TS on EGFR is similar to that of gefitinib. The MTT assay demonstrated that gefitinib and TS (especially TI) could inhibit the growth of EGFR highly expressed cell lines in a dose‐dependent manner in the range of 5–50 μmol/L. In conclusion, the two‐dimensional EGFR/CMC–HPLC–IT–TOF–MS system could be a useful approach in drug discovery from traditional Chinese medicines for searching for potential antitumor candidates. 相似文献
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Multistrain diseases, which are infected through individual contacts, pose severe public health threat nowadays. In this paper, we build competitive and mutative two‐strain edge‐based compartmental models using probability generation function (PGF) and pair approximation (PA). Both of them are ordinary differential equations. Their basic reproduction numbers and final size formulas are explicitly derived. We show that the formula gives a unique positive final epidemic size when the reproduction number is larger than unity. We further consider competitive and mutative multistrain diseases spreading models and compute their basic reproduction numbers. We perform numerical simulations that show some dynamical properties of the competitive and mutative two‐strain models. 相似文献
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从专利制度和技术创新的内涵特征入手,阐述专利制度在企业技术创新过程中的专利信息保障、专利情报导向、知识产权保护和激励创新等作用机制,然后指出我国企业技术创新中专利制度作用的不足,并提出相应的解决对策。 相似文献
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古建筑声学现象具有重要的文化价值,其测量和分析均依赖现场采集的数据,实验室使用的信号发生器便携性较差,价格比较高不适用于室外测量,具有强大数据分析和处理能力的Matlab软件成为最佳选择.本文介绍基于声卡和matlab设计的虚拟图形化信号发生器,其具有生成建筑声学需求的特殊频率信号能力,提供频率自定义和脉冲调制功能,可实现白噪声发生功能.本文给出了具体实现方法和实际采集的波形结果. 相似文献
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从转变教学形式、加强实验课时以及调整考核形式等方面,探讨了Mathematica与解析几何课程整合的一些措施,整合的实质即建设解析几何实验课程. 相似文献
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Tungsten doped mesoporous SBA‐16 as novel heterogeneous catalysts for oxidation of cyclopentene to glutaric acid
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Novel heterogeneous tungsten species in mesoporous silica SBA‐16 catalysts based on ship‐in‐a‐bottle methodology are originally reported for oxidizing cyclopentene (CPE) to glutaric acid (GAC) using hydrogen peroxide (H2O2). For all W‐SBA‐16 catalysts, isolated tungsten species and octahedrally coordinated tungsten oxide species are observed while WO3 crystallites are detected for the W‐SBA‐16 catalysts with Si/ W = 5, 10, and 20. The specific surface areas and the corresponding total pore volumes decrease significantly as increasing amounts of tungsten incorporated into the pores of SBA‐16. Using tungsten‐substituted mesoporous SBA‐16 heterogeneous catalysts, high yield of GAC (55%) is achieved with low tungsten loading (for Si/W = 30, ~13 wt%) for oxidation of CPE. The W‐SBA‐16 catalysts with Si/W = 30 can be reused five times without dramatic deactivation. In fact, low catalytic activity provided by bulk WO3 implies that the highly distributed tungsten species in SBA‐16 and the steric confinement effect of SBA‐16 are key elements for the outstanding catalytic performance. 相似文献