Electrochemical reduction and voltammetric determination of metronidazole at a nanomaterial thin film coated glassy carbon electrode

Simple and sensitive electrochemical method for the determination of metronidazole, based on a nanostructured film coated glassy carbon electrode (GCE), is described. Multi-walled carbon nanotubes (MWNT) was dispersed into water in the presence of a hydrophobic surfactant to give very stable and homogeneous MWNT suspension, and a MWNT-film coated GCE was achieved via evaporating solvent. Metronidazole yields a well-defined reduction peak whose potential is −0.71 V at the MWNT-film coated GCE in pH 9.0 Britton-Robinson buffer. Compared with bare GCE, the MWNT-film modified GCE significantly enhances the reduction peak current of metronidazole. All the experimental parameters were optimized for the determination of metronidazole. The detection limit is 6×10⁻⁹ mol/l at 2 min accumulation. This method has been successfully used to determine metronidazole in the drugs. Furthermore, results obtained by the proposed method have been compared with spectrophotometric method.     

赖氨酸修饰壳聚糖磁性超微载体的制备和表征

本文设计并合成了良好水溶性的赖氨酸修饰壳聚糖,并对制备工艺进行了优化.产物通过红外(FTIR)和核磁(1H-NMR)进行了表征,并将其作为壳层材料制备了赖氨酸修饰壳聚糖磁性超微载体.通过光电能谱(XPS)、透射(TEM)、激光粒度仪、X射线衍射(XRD)、磁性能测试(VSM)对载体进行了表征.结果表明,制备的赖氨酸修饰壳聚糖磁性超微载体表面带有大量的氨基(-NH2),粒径分布较为均一(100nm左右),形貌较为规则,并具有良好的超顺磁性,因而该载体具有更加良好的性能.     

Pd_2(dba)_3/BINAP催化合成1,4-双-(4′-苯胺基苯酰基)苯

以Pd2(dba)3/BINAP催化1,4-双-(4′-溴苯酰基)苯和苯胺反应,合成了1,4-双-(4′-苯胺基苯酰基)苯,其结构经UV,1HNMR,13CNMR和元素分析表征。     

Preparation of mesoporous aluminophosphate using poly(amido amine) as template

Mesoporous aluminophosphate was prepared by using G4.0 poly(amido amine)dendrimer as a template and characterized by Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and N₂ adsorption/desorption methods. Results show that the title compound exhibits a typical mesoporous structure with the average pore size from 5 to 8 nm. The formation mechanism of the nanoporous structure using dendrimer as a template was also discussed. __________ Translated from Journal of Fujian Normal University (Natural Science Edition), 2007, 23(2): 67–70 [译自: 福建师范大学学报 (自然科学版)]     

HPLC–MS Analysis of Isoniazid in Dog Plasma

A simple, rapid, and sensitive liquid chromatography–mass spectrometric (LC–MS) method was developed and validated for the determination of isoniazid in dog plasma. Plasma samples were deproteined with methanol and separated on a C₁₈ column interfaced with a single quadrupole mass spectrometer, using 0.1% formic acid–acetonitrile (91:9 v/v) as mobile phase. Detection was performed by positive electrospray ionization with selected ion monitoring at m/z 138 for isoniazid and 152 for entecavir maleate internal standard. Linearity was obtained over the range of 25–5,000 ng mL^?1, with a lower limit of quantification of 25 ng mL^?1. The intra- and inter-day precision was less than 2.7% in terms of relative standard deviation. Accuracy, expressed as relative error, ranged from ?2.0 to 8.0%. Plasma samples were analysed within 5 min. The method was successfully applied to the evaluation of the pharmacokinetics of isoniazid in dog plasma.     

PPC/SBR并用弹性体的配方选择

利用正交法对丁苯橡胶（SBR）／聚丙撑碳酸酯（PPC）共混弹性体进行配方设计，得到了一个具有良好综合性能的配方。并通过方差分析得出PPC含量和马来酸酐（MA）用量是影响弹性体拉伸性能的最显著因素。     

微波照射合成不对称1，4－二氢吡啶的研究

微波照射合成不对称１，４－二氢吡啶的研究张雅文，沈宗旋，潘备，杨海康，陆新华，陆澄容（苏州大学化学系苏州２１５００６）关键词缩合，二氢吡啶，微波Ｈａｎｔｚｓｃｈ合成是制备１，４－二氢吡啶的经典方法。这一合成的改进方法之一是３－氨基巴豆酸酯与醛和乙酰乙...     

从蓖麻油制取10-羟基癸酸的研究

本文报道了从蓖麻油制取10-羟基癸酸的研究,发现了从蓖麻油制取10-羟基癸酸的新的工艺路线和最佳的工艺条件,用氢氧化钠用量、2-辛醇量、反应时间和反应温度四因子三水平L_9(3~4)进行了正交试验,发现最佳工艺条件是:氢氧化钠(g)/蓖麻油(g):1.25:2-辛醇量(g)/蓖麻油(g):2:反应时间:6h;反应温度:180℃。在这一新的工艺路线和最佳工艺条件下,10-羟基癸酸产率可达75％。     

氨基酸电位波谱分析机理的研究

本文研究了镍与酪氨酸、胱氨酸、脯氨酸、亮氨酸形成的四组络合物,在pH=10的Na_2B_4O_7·10H_2O-CH_3CHO-NaOH体系中,应用示波极谱进行电位扫描,出现四组灵敏度和分率辨均很高的电位波谱,为同时连续测定多组份共同存在的氨基酸分析方法提出一条新的途径。