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911.
912.
在乙酸乙酯皂化反应实验数据的处理过程中,通常要假设反应物NaOH和CH3COOC2H5的起始浓度已知并且相等,因此,实验中要特别注意反应物起始浓度的准确性[1,2]。双管反应器是目前该实验的常用装置(图1)。实验时,先将具有相同浓度的等量反应物NaOH和CH3COOC2H5分别置于反应器的A、B管中,恒温后,用洗耳球将B管中的溶液压入A管进行混合。这一过程的缺点是,学生手动挤压洗耳球时,往往难以控制,不能很好地将A、B管的溶液混合均匀[1,2];另外,溶液混合之后,分别在A、B管中反应。这些都很难保证A、B两管中反应物的起始浓度准确一致,从而可能… 相似文献
913.
Rational design of enzymes is a stringent test of our understanding of protein structure and function relationship, which also has numerous potential applications. We present a novel method for enzyme design that can find good candidate protein scaffolds in a protein-ligand database based on vector matching of key residues. Residues in the vicinity of the active site were also compared according to a similarity score between the scaffold protein and the target enzyme. Suitable scaffold proteins were selected, and the side chains of residues around the active sites were rebuilt using a previously developed side-chain packing program. Triose phosphate isomerase (TIM) was used as a validation test for enzyme design. Selected scaffold proteins were found to accommodate the enzyme active sites and successfully form a good transition state complex. This method overcomes the limitations of the current enzyme design methods that use limited number of protein scaffold and based on the position of ligands. As there are a large number of protein scaffolds available in the Protein Data Band, this method should be widely applicable for various types of enzyme design. 相似文献
914.
二维相关光谱是一项将光谱强度看作两个独立的光谱变量的函数的技术, 它是由动态光谱经过数学转化后得到的. 在扰动过程中, 动态光谱等于实际测得的光谱减去参考谱, 参考谱的选择是任意的, 甚至可以为0, 但是在实际应用时, 人们逐渐发现参考谱的选择会对二维相关光谱产生一定的影响. 本篇文章采用模拟的方法, 建立光谱模型, 光谱强度按e指数形式单调变化, 比较以平均谱为参考谱和不设参考谱得到的二维相关光谱图, 分析它们的区别, 在不同参考谱条件下, 利用二维相关光谱分离重叠峰, 得到的结果也不相同, 将两种条件综合利用可以得到更多更正确的信息. 相似文献
915.
Shih-Hsiung Chen Rey-May Liou Yen-Yi Lin Cheng-Lee Lai Juin-Yih Lai 《European Polymer Journal》2009,45(4):1293-1301
This paper presents an original approach to prepare the asymmetric sulfonated polysulfone membranes by using wet phase inversion method and their applications for dehydrating a water/ethanol mixture by pervaporation. The separation performances of sulfonated membranes were strongly affected by the degree of sulfonation and the degree of swelling of membranes. The substitution degree of sulfonic group enhanced the permselectivity of sulfonated polysulfone membranes by increasing the hydrophilicity of polymer backbone. Based on the observations of membrane morphology and light transmittance measurements, the degree of sulfonation of polysulfone presented less influence on the membrane formation pathway and the final structure of membrane in wet phase inversion process. It was also found that the sulfonated membranes showed well hydrophilic properties and facilitated water adsorption in the membranes. The sorption and permeation properties also showed that the permselectivity of asymmetric membrane was dominated by the permeate diffusion rather than the permeate sorption in the skin layer. The high separation performance of pervaporation membrane can be achieved by phase inverse method with sulfonated polysulfone. 相似文献
916.
The rate capability and cyclic performance of the LiNi0.5Mn1.5O4 under high current density have been significantly improved by doping a small amount of ruthenium (Ru). Specifically, Li1.1Ni0.35Ru0.05Mn1.5O4 and LiNi0.4Ru0.05Mn1.5O4 synthesized by solid state reaction can respectively deliver a discharge capacity of 108 and 117 mAh g?1 at 10 C rate between 3 and 5 V. At 10 C charge/discharge rate, Li1.1Ni0.35Ru0.05Mn1.5O4 and LiNi0.4Ru0.05Mn1.5O4 can respectively maintain 91% and 84% of their initial capacity after 500 cycles, demonstrating that Ru-doping could be a way to enhance the electrochemical performance of spinel LiNi0.5Mn1.5O4. 相似文献
917.
Chun-Ze Lai Marti M. Joyer Melissa A. Fierke Nicholas D. Petkovich Andreas Stein Philippe Bühlmann 《Journal of Solid State Electrochemistry》2009,13(1):123-128
Solid-contact ion-selective electrodes (SC-ISEs) can exhibit very low detection limits and, in contrast to conventional ISEs,
do not require an optimization of the inner filling solution. This work shows that subnanomolar detection limits can also
be achieved with SC-ISEs with three-dimensionally ordered macroporous (3DOM) carbon contacts, which have been shown recently
to exhibit excellent long-term stabilities and good resistance to the interferences from oxygen and light. The detection limit
of 3DOM carbon-contacted electrodes with plasticized poly-(vinyl chloride) as membrane matrix can be improved with a high
polymer content of the sensing membrane, a large ratio of ionophore and ionic sites, and conditioning with a low concentration
of analyte ions. This permits detection limits as low as 1.6 × 10−7 M for K+ and 4.0 × 10−11 M for Ag+. 相似文献
918.
Quan‐Bin Han Lina Wong Fanny Lai Nian‐Yun Yang Jing‐Zheng Song Chun‐Feng Qiao Hong‐Xi Xu 《Journal of separation science》2009,32(2):309-313
In order to provide the chemical markers for the quality control of herbal medicines, four diterpenoids, pseudolaric acids A and B (PAA and PAB), and their glucosides were isolated from the methanol extract of the Chinese herb Pseudolarix kaempferi using high‐speed counter‐current chromatography (HSCCC). The diphase solvent system was n‐hexane/EtOAc/MeOH/H2O which was used at two ratios (5:5:5:5 and 1:9:4:6 by volume) in the separation of pseudolaric acids and their glycosides, respectively. As a result, PAA (14 mg), PAB (129 mg), PAA‐O‐β‐D ‐glucopyranoside (8 mg, PAAG), and PAB‐O‐β‐D ‐glucopyranoside (42 mg, PABG) were obtained from 0.5 g of the crude extract. Their purities were determined to be above 97% by HPLC analysis. Their chemical structures were confirmed by 1H and 13C NMR analysis or HPLC comparison with the reference compounds. 相似文献
919.
The piecewise algebraic variety is the set of all common zeros of multivariate splines. We show that solving a parametric
piecewise algebraic variety amounts to solve a finite number of parametric polynomial systems containing strict inequalities.
With the regular decomposition of semi-algebraic systems and the partial cylindrical algebraic decomposition method, we give
a method to compute the supremum of the number of torsion-free real zeros of a given zero-dimensional parametric piecewise
algebraic variety, and to get distributions of the number of real zeros in every n-dimensional cell when the number reaches the supremum. This method also produces corresponding necessary and sufficient conditions
for reaching the supremum and its distributions. We also present an algorithm to produce a necessary and sufficient condition
for a given zero-dimensional parametric piecewise algebraic variety to have a given number of distinct torsion-free real zeros
in every n-cell in the n-complex.
This work was supported by National Natural Science Foundation of China (Grant Nos. 10271022, 60373093, 60533060), the Natural
Science Foundation of Zhejiang Province (Grant No. Y7080068) and the Foundation of Department of Education of Zhejiang Province
(Grant Nos. 20070628 and Y200802999) 相似文献
920.
Wang SJ Zhang ZQ Zhao YH Ruan JX Li JL 《Rapid communications in mass spectrometry : RCM》2006,20(15):2303-2308
A simple, rapid and sensitive method was developed for the simultaneous quantification of chlorogenic acid (CGA) and caffeic acid (CA) in rat plasma using a high-performance liquid chromatography system coupled to a negative ion electrospray mass spectrometric analysis. The plasma sample preparation was a simple deproteinization by the addition of two volumes of acetonitrile followed by centrifugation. The analytes and internal standard ferulic acid were separated on an Intersil C8-3 column (5 mm; 250 x 2.1 mm) with acetonitrile/0.05% triethylamine solution (70:30, v/v) as mobile phase at a flow rate of 0.2 mL/min with an operating temperature of 30 degrees C. Detection was performed on a quadrupole mass spectrometer equipped with an electrospray ionization (ESI) source operated in selected ion monitoring (SIM) mode. Negative ion ESI was used to form deprotonated molecules at m/z 353 for chlorogenic acid, m/z 179 for caffeic acid, and m/z 193 for the internal standard ferulic acid. Linear detection responses were obtained for CGA concentrations ranging from 0.005 to 2.0 microg/mL and for CA concentrations ranging from 0.010 to 2.0 microg/mL and the lower limits of quantitation (LLOQs) for CGA and CA were 0.005 and 0.01 microg/mL, respectively. The intra- and inter-day precisions (RSD%) were within 9.0% for both analytes. Deviation of the assay accuracies was within +/-10.0% for both analytes. Their average recoveries were greater than 88.0%. Both analytes were proved to be stable during all sample storage, preparation and analytic procedures. The method was successfully applied to the pharmacokinetic study of CGA and CA following an intravenous dose of 5 mL/kg mailuoning injection to rats. 相似文献