Highly enantioselective fluorescent recognition of α-amino acid derivatives

Bisbinaphthyl-based macrocycles are found to carry out enantioselective fluorescent recognition of α-amino acid derivatives. It is observed that one enantiomer of a N-protected phenyl glycine can increase the fluorescence intensity of the binaphthyl fluorophores by over 4-fold but the other enantiomer does not cause much fluorescence enhancement. This highly enantioselective fluorescent response makes the binaphthyl macrocycles practically useful for the enantioselective fluorescent recognition of the amino acid substrate.     

IGF-PI3K-Akt信号通路在生理性心肌肥大中的作用研究进展

心肌肥大是心肌细胞对多种刺激因素的复杂反应。心肌肥大可以分为三种:心肌的正常生长、运动诱导生理性心肌肥大和病理性心肌肥大。近年来,研究表明心肌的正常生长以及运动诱导的心肌生理性肥大,主要是通过IGF-PI3K-Akt信号通路进行信号转导。本文就IGF-PI3K-Akt信号转导通路的结构特点、调节过程作一综述。     

Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

PVC基活性炭的制备及其吸附性能的研究Ⅰ——PVC沥青的制备及其预氧化

以PVC树脂为原料,采用两个恒温段的程序升温方法加热脱氯制备PVC沥青,并通过空气预氧化法,对所制备的PVC沥青进行了预氧化处理.实验结果表明,PVC树脂在流速为100 mL/min氮气气氛中,以10℃/min速率程序升温至270℃,恒温脱氯150 min后再程序升温至410℃并恒温芳化120 min,可以制备出脱氯率和得率均较高的PVC沥青.该PVC沥青在300℃温度下,采用空气预氧化法预氧化120min,可获得增重率约为11%,氧化交联度较高、耐热性能较好的预氧化PVC沥青.FT-IR光谱分析结果表明,PVC沥青在预氧化的过程中,主要发生了氧化脱氢、脱水、CO2缩聚交联反应,使沥青形成耐热型的氧桥结构,从而达到预氧化目的.     

DRM单频网规划与实现

DRM是频率在30MHz以下的数字广播系统,抗多径衰弱和干扰强,适合实现单频网,本文在DRM单频网仿真分析的基础提出了网络规划策略,描述了实现发射机时延校正方法.     

代数方法在C语言图形打印问题中的应用

介绍了C语言程序设计中的难点问题——图形打印问题的解决方案，详细论述了如何利用代数方法来解决这一双重循环问题的具体措施。     

一个增算子不动点定理及其在Banach 空间非线性方程的应用

给出了Banach空间的一个增算子不动点定理,将这一定理应用到Banach空间的积分-微分方程,给出了一类积分-微分方程的连续可微最大解和连续可微最小解的存在性定理.