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81.
The immobilization of proteins, especially receptor proteins commonly used in high through-put screening of drugs (HTS), have received great attention in recent years. There are many successful isothermal models for describing the adsorption of protein onto solid surface, such as Langmuir model, Bi-Langmuir model, Fowler model, Freundlich model, Freundlich-Langmuir model and Tekmin model etc. In all these models, Langmuir model was the most favorable one model accepted by many researchers, but the experimental results showed that it was not entirely fit to all adsorption behaviors. So new models were required for describing protein adsorption onto microspheres in different conditions.In our research, a novel isothermal model, including Langmuir and other adsorbing behaviors was presented basing on the holding degree of surface active sites and the interaction styles of protein immobilization. In Langmuir model, the adsorbing amount of protein was described as [PS] =Km[P]/1 + K[P], where [PS] was the concentration of adsorbed protein, [P] was the concentration of freeprotein at equilibrium state, and Km and K was constant. According to the interactions of protein and ligands, there were three patterns in the interactions of protein and ligands. On the similar assumption that the interaction of protein and microspheres were three styles, and based on the definition of the holding degree of surface active sites (Y), three adsorption behaviors could be described as Y K[ P ]φ/ K[P]φ+1 or ln K + φ ln[P] =ln(Y/1-Y) in which [P] was the concentration of free protein at equilibrium state, and φ and K was constant. Different scale of φ presented different adsorption behaviors, especially when φ was 1, the adsorption behavior was Langmuir adsorbing model. Figure I indicated the different adsorbing results in different adsorption behaviors (φ>1, φ<1,and φ=1). 相似文献
82.
Ming Zhao WANG Guan Liang CAI Ling XIA Jun Jian YAO Hong Yan CHEN Zhao Xing MENG Bo Li LIUDepartment of Chemistry Beijing Normal University Beijing Chemical Defense Institute PLA Beijing 《中国化学快报》2004,15(4):495-497
The crystal structures of two potential tumor imaging agents and therapeutic agents -copper(Ⅱ) complexes with salicylidene-tyrosinato Schiff base and nitrogen-donor chelating Lewis base, [Cu(sal-tyr)(bipy)] 1 and [Cu(sal-tyr)(phen)]2CH3OH 2 are presented. Our work is helpful to get deep understanding of novel 64Cu tumor imaging agents and therapeutic agents. 相似文献
83.
目的 探讨PDS线网内固定治疗髌骨骨折的临床疗效.方法 对92例髌骨骨折分别采用A0法、聚髌器 法及PDS线网法治疗结果的回顾性分析比较.结果 A0法、聚髌器法及PDS线网法优良率分别为96-2%、75%、94.1%,并发症发生率分别为60%、41.7%、6%.结论 PDS线网法是治疗髌骨骨折的一种有效方法.并发症发生率明显减少. 相似文献
84.
生长调节剂对大叶白蜡幼苗生长的影响 总被引:2,自引:0,他引:2
对一年生大叶白蜡实生苗用3种不同浓度的赤霉素(GA3)、ABT生根粉7号(ABT7)、萘乙酸(NAA)进行处理。结果表明,3种生长调节剂对大叶白蜡幼苗生长有明显的促进作用。处理后的苗木提高,生长加快,茎干增粗,叶片增大,抗性增强,其中以50mg/L的GA3作用最为显著。 相似文献
85.
86.
LI Zi-jian LIU Ning LIU Zhi-qiang LIU Shu-ying HAN Qi-de ZHANG You-yi . Institute of Vascular Medicine Peking University Third Hospital Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing P. R. China . Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun P. R. China 《高等学校化学研究》2006,22(3):319-323
Introduction Adrenoceptors(ARs),membersofthesuperfami lyofG proteincoupledreceptors,arethemostimpor tantreceptorsinvolvedincardiacregulation[1].ARsin cardiacmuscleincludebothαARsandβARssub types,whileinmostmammalianheart,βARsarethe predominantsubtypes.… 相似文献
87.
Cobalt antidot arrays with different thicknesses are fabricated by rf magnetron sputtering onto porous alumina substrates. Scanning electron microscopy and grazing incidence x-ray diffraction are employed to characterize the morphology and crystal structure of the antidot array, respectively. The temperature dependence of magnetic properties shows that in the temperature range 5K--300K, coercivity and squareness increase firstly, reach their maximum values, then decrease. The anomalous temperature dependences of coercivity and squareness are discussed by considering the pinning effect of the antidot and the magnetocrystalline anisotropy. 相似文献
88.
主要介绍了丝绸之路上多元文化的典型代表——艾德莱斯绸.文章重点介绍了艾德莱斯绸的历史和传说,扎经染色工艺,各类艾德莱斯绸的特点及典型的艾德莱斯绸图案. 相似文献
89.
本文给出了Banach空间广义分解定理的一个初等证明,并利用它来证明两个对称不等式.这是首次在Banach空间获得这样的不等式. 相似文献
90.
刘爽 《沈阳大学学报:自然科学版》2006,18(1):93-95
从总体形象、结构、语言、人物等不同侧面,剖析了荒诞艺术形式反映的荒诞世界的疯狂与残酷。 相似文献