Singularities of Berry connections inhibit the accuracy of the adiabatic approximation

Adiabatic approximation for quantum evolution is investigated addressing its dependence on the Berry connections that are functions of a slowly-varying parameter R  . When the Berry connections have singularities of type 1/Rσ$1/R^{\sigma }$ with σ<1$\sigma <1$, the adiabatic fidelity converges to unit according to a power-law; When the singularity index σ becomes larger than one, adiabatic approximation breaks down. Two-level models are used to substantiate our theory.     

A Fe<Superscript>3+</Superscript>/Hg<Superscript>2+</Superscript>-Selective Anthracene-Based Fluorescent PET Sensor with Tridentate Ionophore of Amide/β-Amino Alcohol

A new anthracene-based fluorescent PET sensor 1 with a tridentate ionophore of amide/β-amino alcohol displays very good selectivity and sensitivity for Fe³⁺ (K _a = 1.6 × 10³ M⁻¹) and Hg²⁺ (K _a = 2.1 × 10³ M⁻¹) in CH₃CN–H₂O (3:7, v/v) with detection limit of 1 μM. More fluorescence enhancement was observed when 1 selectively detected Fe³⁺ or Hg²⁺ in CH₃CN and its detection limit was up to 0.03 μM.     

纳米氧化锌的过饱和控制生长与大小分布控制.

"在非水介质中合成了纳米氧化锌,测定了纳米氧化锌的紫外吸收光谱,并用有效质量模型计算了粒子大小,开发并命名了一种称之为纳米粒子过饱和控制生长的技术,该技术涉及将小的纳米粒子悬浊液加入到大的粒子悬浊液中,结果因为不同大小粒子间的溶解度差异小的粒子将全部溶解,大的粒子将整体长大,大粒子悬浊液的粒子数将保持不变,大粒子的生长速度显著比Ostwald老化的高．该技术最显著的特征是只要最初两悬浊液粒子大小的差异足够大,分布不是太宽,则粒子大小的分布将会因为粒子如此长大而变窄．"     

Human CtIP promotes DNA end resection

In the S and G2 phases of the cell cycle, DNA double-strand breaks (DSBs) are processed into single-stranded DNA, triggering ATR-dependent checkpoint signalling and DSB repair by homologous recombination. Previous work has implicated the MRE11 complex in such DSB-processing events. Here, we show that the human CtIP (RBBP8) protein confers resistance to DSB-inducing agents and is recruited to DSBs exclusively in the S and G2 cell-cycle phases. Moreover, we reveal that CtIP is required for DSB resection, and thereby for recruitment of replication protein A (RPA) and the protein kinase ATR to DSBs, and for the ensuing ATR activation. Furthermore, we establish that CtIP physically and functionally interacts with the MRE11 complex, and that both CtIP and MRE11 are required for efficient homologous recombination. Finally, we reveal that CtIP has sequence homology with Sae2, which is involved in MRE11-dependent DSB processing in yeast. These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination.     

凤凰座SX型变星CY Aqr光变周期长期变化研究的新进展

通过对凤凰座SX型变星CY Aqr的观测测定了2个新的光变极大时刻,并利用文献中光变曲线资料得出了3个新的光变极大时刻.结合已发表的数据点,拟合得出新的极大时刻计算公式,并作出了O-C图.用新的数据检验现有的两种解释该星周期变化的理论表明轨道光时效应模型更为合理.     

塔里木河流域中下游典型地物光谱变化规律

由于塔里木河流域中下游距离河道在垂直向的差别,以及气候与人为因素的影响,使植被的空间分布具有异构性.典型地物光谱变化的研究为中下游生态环境的遥感监测提供了基础,实验研究表明:绿色全荣植物中,棉花由于其具有明显绿峰、水分吸收谷和近红外的高反射峰而更加容易识别,其他植物主要差别则集中在550,680,1420 nm附近的反射峰、吸收谷和1920～2500 nm之间的反射率;与绿色植被相比,枯枝的光谱在可见光部分的绿峰和红光吸收谷不明显,但在可见光部分波形有所差别,而与流沙土壤光谱相比,各波段反射率变化较大;对比不同荣枯比例的植物光谱发现,同一种植物随着荣枯配比的变化,除可见光绿峰、近红外反射峰和各水分吸收谷变化外,最明显的是在近红外1420～1820 nm之间和短波红外1920～2500 nm之间反射率随着枯枝的比例增加而明显升高;关于土壤光谱,中下游各断面占主要类型的流沙土光谱相差不大,但是盐碱土和含有一定水分的盐碱土则变化较大,而且反射率基本低于流沙土,结壳土则除在近红外和短波红外部分变化更加平缓而有所差别外,其余波段接近流沙土;同样的土壤背景下,近红外和短波红外部分反射率的差别能够在一定程度上反映覆盖度的变化.     

基于真实三维结构的玉米冠层生化参数垂直分布的定量化分析

为了定量研究作物生化参数在冠层中的垂直分布情况,本文以2000年栾城实验测量的玉米冠层自上而下不同叶位叶片的光谱数据为基础,利用PROSPECT模型进行反演,获得每层叶片的叶绿素(a b)含量、等效水厚度、干物质含量等叶片的生化参数.通过比较发现:玉米冠层叶绿素等含量生化参数具有明显的随高度垂直分层现象,最明显的就是叶片的叶绿素含量,最大和最小叶绿素含量的相对差值甚至可以达到最大值的79.1%.在此基础上,根据实测玉米冠层结构,利用扩展L系统生成玉米真实三维结构冠层场景.通过统计计算每层叶片的生化参数,进而得到冠层生化参数的垂直分布.这为进一步基于冠层光谱的参数反演和定量分析以及农业应用等研究奠定了理论基础.     

循环经济发展模式系统仿真方法研究———煤炭行业的实例分析

通过对煤炭业循环经济模式的分类研究,发现尚无在循环经济模式基础上分析主业、产业链影响因 素之间数量关系的科学方法,而系统仿真方法比较适合解决这类问题。依托煤炭主业,设计了一套适于解决类 似大型复杂系统的仿真方法,指出了这种方法的适用范围和局限性。并以YM集团为例,对其循环经济发展模 式进行了详细的验证,得出YM集团发展循环经济有益的结论,同时说明了该方法在分析煤炭行业循环经济发 展模式方面的适用性与有效性。     

Positively charged liposomes consisting of the KTTKS pentapeptide conjugated with rhodamine increase rhodamine toxicity in E. coli and zebrafish embryo

Liposomes composed of cell‐penetrating peptide derivatives increased transport across the cell membrane. Conjugating rhodamine to a cell‐penetrating peptide increased the toxicity of rhodamine in E. coli and zebrafish embryos. A similar total protein inhibition pattern with different intensities, indicating that the interaction pathways of the rho‐KTTKS‐CONH₂ monomer and liposomes were the same. It suggests that the rho‐KTTKS‐CONH₂ liposomes showed higher toxicity because better transport across the cell membrane increased the effective concentration inside cells. The staining of zebrafish embryos using rho‐KTTKS‐CONH₂ liposomes showed a longer retention time, suggesting that it can penetrate deeper tissues or organs in zebrafish.     

Design,syntheses and antitumor activities evaluation of 1,5-diaryl substituted pyrazole secnidazole ester derivatives

According to the drug hybridization principle, a series of novel 1,5-diaryl substituted pyrazole secnidazole ester derivatives ( 6aa – 6gc ) have been synthesized by the combinations of various 1,5-diarylpyrazole-3-carboxylic acids with secnidazole. The in vitro antitumor/cytotoxicities activities against tumor and normal cell lines, including NCI-H460 (lung tumor cell), MCG-803 (gastric tumor cell), Skov-3 (ovarian tumor cell), BEL-7404 (liver tumor cell) and HL-7702 (normal liver cell), have been evaluated using MTT assay. All compounds showed promising inhibitory activities against four tumor cell lines. The IC₅₀ of 6bc against the BEL-7404 cell was 2.03 μM, and those of 6fc against the NCI-H460, MCG-803 and Skov-3 were 1.34, 0.14, and 0.87 μM, respectively. All these values were much lower than those of the cisplatin. Furthermore, 6fc and 6bc were also verified to be considerably safe for normal human liver cell, since the lower IC₅₀ values than cisplatin. Based on these results, the cell cycle analysis, apoptosis ratio detection and mitochondrial membrane potential assay of 6fc and 6bc were further performed aiming to investigate their inhibition mechanism of BEL-7404 cells. It is revealed that they have effectively inhibited the cell growth by arresting the BEL-7404 cells at S phase and induced apoptosis through the mitochondria-mediated pathway.