Comparative absorption kinetics of seven active ingredients of Eucommia ulmoides extracts by intestinal in situ circulatory perfusion in normal and spontaneous hypertensive rats

Eucommia ulmoides Oliv. (E. ulmoides) is a valuable and nourishing medicinal herb in China that has been used in the treatment of hypertension. Given the fact that most traditional Chinese medicine is mainly used to treat disease, investigating the pharmacokinetics of traditional Chinese medicines in the pathological state is more useful than that in the normal state. However, the differences in the absorption kinetics of active ingredients of E. ulmoides extract between pathological and physiological conditions have not been reported. Therefore, in this study, the rat intestinal in situ circulatory perfusion model was used to investigate the differences in absorption kinetics of seven active ingredients of E. ulmoides extract in normal and spontaneously hypertensive rats, namely, genipinic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, (+)-pinoresinol di-O-β-D -glucopyranoside and (+)-pinoresinol 4′-O-β-D -glucopyranoside. Our results indicate that the pathological state of spontaneous hypertension may change the absorption of active components of E. ulmoides extracts, and these findings may provide a reference for improving the rational use of E. ulmoides in the clinic.     

The Berry–Esseen bounds of the weighted estimator in a nonparametric regression model

Consider the following nonparametric model: \(Y_{ni}=g(x_{ni})+ \varepsilon _{ni},1\le i\le n,\) where \(x_{ni}\in {\mathbb {A}}\) are the nonrandom design points and \({\mathbb {A}}\) is a compact set of \({\mathbb {R}}^{m}\) for some \(m\ge 1\), \(g(\cdot )\) is a real valued function defined on \({\mathbb {A}}\), and \(\varepsilon _{n1},\ldots ,\varepsilon _{nn}\) are \(\rho ^{-}\)-mixing random errors with zero mean and finite variance. We obtain the Berry–Esseen bounds of the weighted estimator of \(g(\cdot )\). The rate can achieve nearly \(O(n^{-1/4})\) when the moment condition is appropriate. Moreover, we carry out some simulations to verify the validity of our results.

     

双掺(Tm3+,Tb3+)LiYF4激光器1.5 μm波长激光阈值分析

由速率方程推出了双掺（Tm^3 ,Tb^3 ）离子准四能级系统的激光阈值解析式，讨论了Tm^3 和Tb^3 离子之间的相互作用。分析了1.5μm波长附近的激光阈值和Tm^3 、Tb^3 离子的掺杂原子数分数及晶体长度的关系。结果表明，对于对应Tm^3 离子^3H4→^3F4跃迁的约1.5μm波长的激光，激活离子Tm^3 的掺杂原子数分数过大时，交叉弛豫作用将使系统阈值迅速增加。Tb^3 离子的加入，一方面能抽空激光下能级，起到降低阈值的作用；另一方面亦减少了激光上能级的寿命，使阈值升高。故Tb^3 离子有最佳掺杂原子数分数。对于Tm原子数分数为y=0.01的Tm:LiYF4晶体，Tb^3 离子的最佳掺杂原子数分数为0.002左右，同时表明，激光阈值与晶体长度有关。最佳晶体长度与Tm^3 、Tb^3 离子的掺杂原子数分数以及晶体的衍射损耗和吸收损耗有关。     

通风机房峒室系统设计的合理性与性能测试的规范性

通风机性能现场测试的可能性、规范性和准确性很大程度上取决于通风机房与峒室系统设计的的合理性。本文结合通风机性能现场测试规范性提出了设计与改进通风机房与峒室系统的建议。图５，参３。     

YBa2Cu1-xCox(Cu1-yZny)2Oz体系的Co,Zn共同掺杂效应

本文报道通过对YBa₂Cu_1-xCo_x(Cu_1-yZn_y)₂O_z(0≤x,y≤0.1)体系晶体结构、氧含量、正常态电阻-温度关系、Hall效应以及超导临界温度等的综合测量,发现随着Co和Zn含量的增加,体系经历了从正交结构的超导金属向四方结构的非超导半导体的转变,超导临界温度T_c和载流子浓度n_h均迅速下降,Co 关键词：     

α,α′-二氧代烯酮环二氮代缩醛的NMR研究

报道了5种新的α，α′-二氧代烯酮环二氮代缩醛化合物的NMR谱，初步探讨了分子结构对化学位移的影响．     

混合盐水密度模型的建立及应用

在回归得出单盐盐水密度模型的基础上，给出了混合盐水的密度模型。利用盐水密度模型，对混合盐水的最优配制和密度调整计算进行了探讨，给出了含两种盐的水溶液的配制和密度调整的计算公式。     

TZT/AC/PMMA体系光谱烧孔及激光诱导的填孔效应的研究

报道四苯并卟啉锌/芳晴/有机玻璃TZT/AC/PMMA体系光化学烧孔的光谱稳定性、多重烧孔及激光诱导的填孔效应。 关键词：     

O－芳基－苯基硫代膦酰氯和O－芳基－苯基硫代膦酸异硫氰基酯的研究

合成一些新的有机磷化物，组成为（ＡｒＯ）ＰｈＰ（ｓ）Ｙ（Ｙ＝Ｃｌ、ＮＣＳ）．测定了ｍＰ、ＩＲ、ＨＮＭＲ并进行了元素分析．Ｉａ的除草活性尚好．