A new perylene diimide-based colorimetric and fluorescent sensor for selective detection of Cu~(2+) cation

A new perylene diimide (PDI) ligand (1) functionalized with a dipicolylethylenediamine (DPEN) moiety was synthesized and first used as a colorimetric and fluorometric dual-channel sensor to specifically detect the presence of Cu2+ over a wide range of other cations. The solution of 1 (10 μmol/L) upon ad-dition of Cu2+ displayed distinguishing pink color compared with other cations including K+,Ni2+,Ca2+,Mn2+,Na+,Sr2+,Zn2+,Co2+,Cd2+,Mg2+,Cr3+,Ag+,and Ba2+,indicating the sensitivity and selectivity of 1 to Cu...     

Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method for Determination of Protopanaxadiol in Rat Plasma

A simple, rapid and sensitive method for the determination of protopanaxadiol in rat plasma with ginse-noside Rh2 as internal standard was developed and validated. The analyte and internal standard were extracted from plasma with ether-dichloromethane(3:2, volume ratio) and then were analyzed by reversed-phase HPLC on a short Zorbax Extend C18 column(50 mm×2.1 mm, 3.5 μm i. d.) eluted with a mobile phase consisting of acetoni-trile/methanol 0.10 mmol/L ammonium acetate(45:45:10, volume ratio) at 0.4 mL/min....     

主成分分析在研究冠心病病因中的应用

本文采用主成分分析的方法，对导致冠心病的诸多因素进行了分析，并按所起作用的重要程度进行了排序，找出了导致冠心病的关键因素．     

冻干辐照人脐动脉的制备及其物理性能的实验研究

为寻找理想的冠状血管移植物——同种异体小口径血管移植材料，１９９３年７月至１９９４年５月，自行制备采用冻干辐照方法处理人脐动脉血管并进行物理性能的比较．结果表明，经冻干辐照处理之后，该脐动脉血管的物理性能改善，弹性和顺应性都明显提高，仍然保持良好的耐压能力，能够满足移植血管物理性能方面的要求，是一种较好的中小型血管移植物     

恶性组织细胞病微量元素的变化及意义

为研究恶性组织细胞病患者血清微量元素钙(Ca)、磷(P)、镁(Mg)、铁(Fe)、锌(zn)、铜(cu)水平的变化及其意义,用synchron LX20临床生化分析仪检测了反应性组织细胞增多组及恶性组织细胞病(恶组)患者血清微量元素Ca、P、Mg、Fe、Zn、Cu的含量。结果显示,恶组初发组血清Fe、Zn、Cu的含量高于反应性组织细胞增多组及正常对照组,反应性组织细胞增多组Ca、Fe低于恶组初发组及正常对照组。恶组好转／缓解期Fe、Zn水平恢复,而Cu较正常对照组仍高。可见微量元素Fe、Zn、Cu的监测,能反映恶组的恶性程度及病程,有利于协助早期诊断,尤其血清Fe的变化,对于鉴别反应性组织细胞增多,具有非常重要的临床意义及实用价值。     

Predicting the Limit of Intramolecular Hydrogen Bonding with Classical Molecular Dynamics

The energetics of intramolecular recognition processes are governed by the balance of pre‐organization and flexibility, which is often difficult to measure and hard to predict. Using classical MD simulations, we predict and quantify the effective strength of intramolecular hydrogen bonds between donor and acceptor sites separated by a variable alkyl linker in several solvents and crowded solutions. The balance of entropic and enthalpic contributions poses a solvent‐dependent limit to the occurrence of intramolecular H‐bonding. Still, free energies show a constant offset among different solvents with, for example, a 13 kJ mol^?1 difference between water and chloroform. Molecular crowding shows little effect on the thermodynamic equilibrium, but induces variations on the H‐bond kinetics. The results are in quantitative agreement with experiments in chloroform and showcase a general strategy to investigate molecular interactions in different environments, extending the limits of current experiments towards the prospective prediction of H‐bond interactions in a variety of contexts.     

星形细胞瘤CT脑水肿与微结构改变的相互关系

一般认为CT瘤周低密度区是脑水肿。为阐明CT瘤周低密度区的本质,本文分析了2例星形细胞瘤CT瘤周低密度区和瘤中央区标本的微结构变化。发现CT瘤周低密度区标本内有间变的星形细胞,间质疏松。故作者认为CT瘤周低密度区是肿瘤的实际范围,伴有水肿变化。此外,本文对CT瘤周低密度区的成因和脑水肿的发病机制进行了探讨。     

多状态概率转移模型在医院住院管理系统的应用

在医院现代化管理的进程中，医院管理者需要经常了解医院病人的流动情况，尤其是住院病人。根据部门反馈的信息，综合分析，对病人的收容和病床的使用安排作出科学的管理决策。本文试用随机过程理论分析医院住院管理系统，建立了医院住院管理系统的多状态概率转移模型（简称ＨＱＭ模型），并分析了住院管理系统的几个优化指标。     

辽宁大学职工病死调查及分析

本校教职工九年共死亡１０８人，在职工人数２５１２人没有大幅度增加的情况下、死亡率逐年增加，甚至成倍增加。从年龄段分析６１￣７１岁死亡率是高，其次是５１￣６０岁，男比女高，疾病种类占首位的是恶性肿瘤，以下顺序是脑溢血，心肌梗死，肺心病。上述情况与生活环境、不良饮食习惯、烟酒嗜好、环境污染等因素危害身体健康有关。它提醒人们认清损害身体的诸因素，提高防病意识，加强自身保健能力。     

~（35）S－MAbSZ39在荷瘤鼠体内药代动力学研究

以￣（３５）Ｓ标记抗人脑胶质瘤单克隆抗体ＳＺ３９制备成免疫导向放疗剂，在荷人脑胶质瘤裸小鼠体内药代动力学符合三室线性模型，总药时方程为Ｃ＿ｔ＝１５５９２７６ｅ￣（─３．４９ｔ）＋９７７３１３ｅ￣（－０．５ｔ）＋２１６８２ｅ￣（－０．０１７ｔ），Ｔ１／２ａ为０．２３ｈ，Ｔ１／２β为１．４Ｇｈ，Ｔ１／２γ为４２．９ｈ。体内分布研究表明￣（３５）Ｓ－ＭＡｂＳＺ３９可特异性浓聚于胶质瘤，在正常组织中无明显蓄积，发挥了单抗导向的高选择性作用，在给药后第五天，与￣（３５）Ｓ－ｎｌｇＧ及￣（３５）Ｓ相比，特异指数分别为４．１和４．８７，具有显著优越性（Ｐ＞０．０５）。结果揭示３５Ｓ－ＭＡｂＳＺ３９有望作为一种高效低毒的导向放疗制剂应用于胶质瘤治疗，以一周间隔多疗程治疗方案为佳。