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21.
高血压病痰瘀证血栓前状态分子标志物变化及意义 总被引:1,自引:0,他引:1
探讨高血压病痰瘀证患者血栓前状态分子标志物变化和意义.分别采用流式细胞仪、ELISA法、CLAUSS法等,检测高血压病痰瘀证组、非痰瘀证组和正常对照组血小板膜表面糖蛋白CD41和CD62P、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制剂(PAI-1)以及凝血4项指标:血浆凝血酶原时间(PT)、纤维蛋白原(Fib)、凝血酶时间(TT)和活化部分凝血活酶时间(APTT).结果显示:①与对照组比较,高血压病痰瘀证组CD41表达、TT无统计学意义(P>0.05),CD62P表达显著升高(P<0.01),t-PA含量下降(P<0.05),PAI-1含量显著升高(P<0.01 ),Fib含量显著升高(P<0.01),PT、APTT显著缩短(P<0.01);非痰瘀证组CD62P表达升高(P<0.05),t-PA含量下降(P<0.05).Fib含量显著升高(P<0.01),APTT显著缩短(P<0.01),而CD41、PAI-1、PT、TT无统计学意义(P>0.05).②与非痰瘀证组对比,痰瘀证组CD62P表达显著升高{P<0.01),而CD41表达,t-PA、PAI-1含量,PT、Fib、TT和APTT则无统计学意义(P>0.05).由此得出结论:高血压病痰瘀证和非痰瘀证均存在不同程度的血栓前状态,而且痰瘀证较非痰瘀证更为明显,并以CD62P、t-PA、PAI-1、PT、Fib、APTT等的改变为主. 相似文献
22.
Wen Yan HU Wen Ping XU Jian Gong SHI* Yong Chun YANG Guang Xiong ZHOU Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Bejing Hospital of Jiu Quan District Gansu Province Jiuquan Dis 《中国化学快报》2001,(9)
Alangium, the sole genus in the family Alangiaceae, has a variety of about 20 species distributed in the tropical and subtropical area of the Eastern Hemisphere, and 13 species are known to occur in the south of China1. A. plantanifolium and A. chinense are used in chinese traditional medicine for the treatment of rheumatalgia, paralysis, cardianeuria, and wound2. Pharmacological studies of the extracts of these two species showed muscular relaxing activity, and anabasine was considered as t… 相似文献
23.
CHEN Jie DONG Xin-shu GUO Xing-gang The Affiliated Tumor Hospital Harbin Medical University Harbin P. R. China 《高等学校化学研究》2008,24(6)
To explore the functional mechanism of Resveratrol against colon cancer cells Is174t and the growth of colon cancer tissue of tumor-bearing mice,MTT method was used to observe the functions of resveratrol for inhibition against cells ls174t in vitro.Transmission electron microscope was used to observe the cell apoptosis.FCM assay was performed to measure the change of the cell apoptosis rate and of cell cycle,RT-PCR method was used to detect the expressions of bc1-2 and bax mRNA.Western blot method was used to detect the expressions of bc1-2 and bax protein.Cells isi74t were transplanted subcutaneously to nude mice to observe the effect of resveratrol on the growth of subcutaneously transplanted tumor.RT-PCR method was used to detect the expressions of bc1-2 and bax mRNA in the tumor tissue.Western blot method was used to detect the expressions of bc1-2 and bax protein in the tumor tissue.Resveratrol has an effect of inhibiting proliferation of cells ls174t in vitro(P<0.01).It is able to induce the apoptosis of cells Is174t,causing the decrease in the expression of bc1-2 and the increase in the expression of bax.Resveratrol could inhibit the growth of subcutaneously transplanted tumor of nude mice(P<0.05),causing the decrease in the expression of bc1-2 and the increase in the expression of bax.Resveratrol can inhibit the growth of cells 174t and the growth of subcutaneously transplanted tumor.The mechanism is possibly related to the induction of the cell apoptosis and the regulation of bc1-2/bax expression. 相似文献
24.
Gu Ping TANG Zhi Yu WANG College of Life-Science. ZheJiang University Hangzhou Institute of Materials Research & Engineering Singapore Research Link The Second Hospital of Zhejiang University Hangzhou 《中国化学快报》2006,(1)
A new vector, PEG as a core, low Mw PEI was grafted to PEG, and transferrin was conjugated the co-polymer to form PEI-g-PEG-transferrin1,2. NMR, FT-IR and TGA spectroscopy confirmed the structures of activated PEG and the final products. The MW of PEI-g-P… 相似文献
25.
The Synthesis of a New Dumbbell-shaped Compound of Bis-4,4''''-bipyridine Bridged by 2,2''''-Bipyridine 总被引:1,自引:0,他引:1
Xin Hua XU* Rui Liang LU Bing ZHOU Jian Ping LI Yin Quan DENG College of Chemistry Chemical Engineering Hunan University Changsha The First Affiliated Hospital College of Medical Sciences Zhejiang University Hangzhou 《中国化学快报》2004,15(2)
Molecular machine is a new born research field1-5, Stoddart and co-workers firstly reported a molecular shuttles in 19916. In molecular machine a cyclic (bead) moves back and forth like a shuttles between two or more groups (station) having noncovalent interaction with a bead. Dumbbell-shaped component is the key intermediate for the synthesis of molecular machines7. One of the approaches for control movement of the bead is based on coordination reaction intrigue. In our protocol, a ligand… 相似文献
26.
The new desiyn screw of the S.S.P.F. is better than the old. 相似文献
27.
THE PREPARATION OF DOXORUBICIN-POLYVINYLPYRROLIDONE-NANOPARTICLES BY INVERSE EMULSION POLYMERIZATION
LV Fengjiao LIN Huaxiang XU Xiaoping** CHEN Xiaogeng .School of Chemistry Chemical Engineering Fuzhou University Fuzhou China .Fujian Provincial Hospital Fuzhou China 《Chinese Journal of Reactive Polymers》2006,(1)
1. INTRODUCTIONNow the application of biodegradable polymeric nanoparticles used as a controlled release dosage form of anticancer drugs has generated great interest. Polymeric nanoparticles usually use macromolecule material as matrix and drug is embedde… 相似文献
28.
29.
Yong WU* Mei GUAN Pei Jie LI Cheng XU Xiao Chun WU School of Pharmacy West China University of Medical Sciences Chengdu The First Hospital West China University of Medical Sciences Chengdu 《中国化学快报》2001,(1)
Since the last decade, there has been a growing interest in the development of analogues of 1(, 25- dihydroxyvitamin D3 1 with low calcemic effect but increased cell differentiating ability1. Among side chain and the A-ring modifications of 1, the 1(, 25- dihydroxy-22-oxo-vitamin D3 22 and 19-nor-1(, 25- dihydroxyvitamin D3 33 have shown much lower calcemic effect and stronger cell differentiating ability than 1. In this paper, we reported synthesis of 19-nor-1(, 25-dihydroxy-22-oxo-vitamin … 相似文献
30.
刘元侠 《苏州大学学报(医学版)》1989,5(3):338-340
对1086名师生口腔常见病调查分析,弄清了师生口腔病的发病特点,表明口腔卫生保健应是高校预防保健工作的重点之一。 相似文献