Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors

A series of N-substituted iminosugar C-glycosides were synthesized and tested for α-glucosidase inhibition. The results suggested that 6e is a promising and potent α-glucosidase inhibitor. Enzymatic kinetic assays indicated that compound 6e may be classified as an uncompetitive inhibitor. The study of structure-activity relationships of those iminosugars provided a starting point for the discovery of new α-glucosidase inhibitors.     

Oxidative Desulfurization Activity of NIT Nitroxide Radical Modified Metallophthalocyanine

In the present study, metallophthalocyanines were modified with NIT nitroxide radicals through chemical bonds to prepare a series of metallophthalocyanines–NIT catalysts (MPcTcCl₈-NIT, M=Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺) applied for oxidative desulfurization of thiophene (T) in model fuel. The MPcTcCl₈-NIT catalysts were characterized by FTIR, UV-Vis, ESR, and XPS spectra. The oxidative desulfurization activity of MPcTcCl₈-NIT catalysts was studied in a biomimetic catalytic system using molecular O₂ as the oxidant. The MPcTcCl₈-NIT catalysts exhibited high catalytic activities for the oxidation of thiophene in model fuel. The desulfurization rate of ZnPcTcCl₈-NIT for thiophene reached to 99.61%, which was 20.53% higher than that of pure ZnPcTcCl₈ (79.08%) under room temperature and natural light. The results demonstrated that MPcTcCl₈-NIT catalysts could achieve more effective desulfurization rate under milder conditions than that of the metallophthalocyanines. The NIT nitroxide radicals also could improve the catalytic activity of metallophthalocyanine based on the synergistic oxidation effect. The stability experiments for ZnPcTcCl₈-NIT showed that the catalyst still had a high desulfurization rate of 92.37% after five times recycling. All these findings indicate that the application of MPcTcCl₈-NIT catalysts provides a potential new way for the desulfurization performance of thiophene in fuel.     

Improved Stretchable and Sensitive Fe Nanowire-Based Strain Sensor by Optimizing Areal Density of Nanowire Network

Flexible strain sensors, when considering high sensitivity and a large strain range, have become a key requirement for current robotic applications. However, it is still a thorny issue to take both factors into consideration at the same time. Here, we report a sandwich-structured strain sensor based on Fe nanowires (Fe NWs) that has a high GF (37–53) while taking into account a large strain range (15–57.5%), low hysteresis (2.45%), stability, and low cost with an areal density of Fe NWs of 4.4 mg/cm². Additionally, the relationship between the contact point of the conductive network, the output resistance, and the areal density of the sensing unit is analyzed. Microscopically, the contact points of the conductive network directly affect the sensor output resistance distribution, thereby affecting the gauge factor (GF) of the sensor. Macroscopically, the areal density and the output resistivity of the strain sensor have the opposite percolation theory, which affects its linearity performance. At the same time, there is a positive correlation between the areal density and the contact point: when the stretching amount is constant, it theoretically shows that the areal density affects the GF. When the areal density reaches this percolation threshold range, the sensing performance is the best. This will lay the foundation for rapid applications in wearable robots.     

316L不锈钢粉末的电子束选区熔化成形

电子束选区熔化技术在人体植入物、航空航天小批量零件的直接快速制造方面具有重要的意义。为此,该文采用自行研制的电子束选区熔化设备,研究了电子束选区熔化316L不锈钢粉末的工艺参数、微观组织及熔化成形机理。结果表明:电子束电流、作用时间和聚焦电流对层间结合情况影响较大,作用时间和填充线间距对可成形性影响较大;当能量密度系数为62.8 GJ/m3、基板厚度为0.5mm时,制备的成形件晶粒细小,组织均匀,无气孔、裂纹及未熔颗粒等缺陷出现。     

强约束球形装药反应裂纹传播和反应烈度表征实验

炸药燃烧的高温高压气体产物可以进入基体裂纹中引发炸药表面热传导燃烧,形成所谓的对流燃烧。在一定约束条件下,不断上升的气体压力反过来又使炸药基体产生更多的裂纹,为对流燃烧提供更多的通道和燃烧表面积,快速生成大量产物气体导致高烈度反应现象的产生。本文中设计了一种新型强约束球形装药中心点火实验,针对一种HMX为基的PBX炸药,对高烈度反应条件下燃烧裂纹传播和反应增长过程进行了观测,实验中采用测得的反应压力和壳体速度历程对反应烈度进行了量化表征。在带窗口结构中,早期炸药中的燃烧裂纹不可见;中期燃烧裂纹扩展到药球表面时,先形成4条沿经线方向近似对称的主裂纹,随后环向贯通并扩展到整个药球表面;最后的剧烈反应造成强烈发光。上述反应演化经历低压增长阶段约为100 μs,之后伴随着壳体变形膨胀产生剧烈的反应,此时产物压力在约10 μs时间内超过1 GPa,并形成约20%相对于裸炸药爆轰的超压输出。在全钢结构中,20 mm厚的壳体膨胀速度最大可达到500 m/s,此时壳体完全破裂。

     

LARGE-TIME BEHAVIOR OF SOLUTIONS TO THE INFLOW PROBLEM OF THE NON-ISENTROPIC MICROPOLAR FLUID MODEL

We investigate the asymptotic behavior of solutions to the initial boundary value problem for the micropolar fluid model in a half line R+ :=(0,∞).Inspired by t...     

页岩水化作用对支撑剂嵌入影响实验研究

页岩压裂改造过程中大量压裂液进入储层后滞留于孔隙或微裂隙中,滞留的流体与页岩发生复杂的物理-化学作用,会改变储层物性和力学性能,加剧压裂裂缝的支撑剂嵌入程度,从而影响压裂裂缝的导流能力。采用页岩自渗吸测试与支撑剂嵌入实验测试,明确了页岩自渗吸量变化特征以及吸水软化对支撑剂嵌入程度的影响。通过实验研究发现：页岩储层的自渗吸量与黏土矿物含量呈正相关,黏土矿物含量越高,单位体积页岩自渗吸量越大。滑溜水中的助排剂和防水锁剂能降低页岩与压裂液的表界面张力与毛细管力,导致页岩自渗吸量降低。页岩弹性模量越小,相同闭合应力条件支撑剂嵌入深度越大。页岩吸水导致弹性模量和强度降低,支撑剂嵌入深度大幅度提升。支撑剂嵌入深度与闭合压力线性相关,吸水后页岩的支撑剂嵌入深度与闭合应力关系的斜率大幅度提升。地应力对支撑剂嵌入的影响作用明显,围压增加,支撑剂嵌入深度大幅度降低,以期为页岩压裂效果评价和压后产能评估提供参考和理论支撑。     

Simulation of maximum light use efficiency for some typical vegetation types in China

MAXIMUM LIGHT USE EFFICIENCY(ΕMAX)IS THE USE RATE OF PHOTOSYNTHETICALLY ACTIVE RADIATION BY VEGETATION IN AN IDEAL CONDITION WITHOUT ANY CONSTRAINTS.IT IS A PHYSIOLOGICAL ATTRIBUTE OF PLANT ITSELF.THE VALUE OFΕMAX IS DIFFERENT FOR DIFFERENT VEGETATION TYPES[1―5].IT IS A KEY PARAMETER FOR THE ESTIMATION OF NET PRIMARY PRODUCTIVITY(NPP)DRIVEN WITH REMOTE SENSING DATA.THERE…     

电厂远程专家分析平台的建立

提出了建立电厂远程专家分析平台的整体方案．合理构建了电厂远程实时运行数据库平台，基于此数据库平台，进行专业应用软件的开发．介绍了远程实时监视、远程经济性分析、远程仿真、远程故障诊断等专业软件的开发思路.     

扰动土与非硬化道路侵蚀产沙规律研究

对扰动土与非硬化道路土壤侵蚀规律进行了研究。通过野外放水冲刷试验,分析扰动土与非硬化道路含沙量、产沙速率与冲刷流量之间的关系。扰动土的含沙量呈下降趋势变化,非硬化路面的含沙量在某一水平线上下波动;不同坡度下平均含沙量随放水冲刷流量变化不同,基本上呈上升趋势,有平缓式上升、快速上升、梯形上升。扰动土累计产沙量呈抛物线式上升,非硬化道路累计产沙量呈直线上升;在部分坡度下,扰动土与非硬化道路的产沙速率相近;不同坡度平均产沙速率随放水流量的增长速度不同;特别是扰动土坡面坡度大于11°,产沙速率有大幅度的增长,工程建设中应特别注意扰动土坡度大于11°的坡面。