Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru(II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.     

Dehydration of tetrafluoropropanol (TFP) by pervaporation via novel PBI/BTDA-TDI/MDI co-polyimide (P84) dual-layer hollow fiber membranes

A novel PBI/P84 co-polyimide dual-layer hollow fiber membrane has been specifically fabricated through the dry-jet wet phase inversion process, for the first time, for the dehydration pervaporation of tetrafluoropropanol (TFP). Polybenzimidazole (PBI) was chosen as the outer selective layer because of its superior hydrophilic nature and excellent solvent-resistance together with robust thermal stability, while P84 co-polyimide was employed as the inner supporting layer because of its good solvent-resistance and thermal stability. The PBI/P84 membrane exhibits superior water selectivity and relatively high permeation flux. At 60 °C, the PBI/P84 dual-layer hollow fiber membrane shows a permeation flux of 332 g/(m² h) and a separation factor of 1990 for a feed solution containing of 85 wt% TFP. The preferential water sorption and the significant diffusivity difference between TFP and water are the main causes of high separation factor. However, an increase in feed temperature will greatly increase the permeation flux but seriously decrease the water selectivity. The activation energy data verify that water can preferentially permeate the PBI membrane due to the strong water affinity of PBI and a much smaller molecular size of water.     

Pruning of orbits in four-disk and hyperbola billiards

It is shown that for the four-disk system and the hyperbola billiard it is possible to construct a new symbolic plane preserving the orientation existing in the dynamical space. Physical orbits are mapped into the topological well-ordered plane and it is shown that the forbidden and allowed orbits are separated by a monotone pruning front.     

微量元素及热处理对ZL107组织和性能的影响

ZL107合金具有良好的铸造性能和较高的力学性能,应用非常广泛,但目前还不能满足现代工程结构中大型、复杂、高强度重要铸件的要求.实验在原有成分的基础上,通过添加微量合金元素、混合稀土变质和选择合理的热处理工艺来进一步提高ZL107的综合力学性能.实验结果表明,改进后的合金经过金属型浇注、T5处理后的力学性能:σb为324.2 MPa,δ5为4.1%,HBS为102,比原ZL107合金分别提高了19.7%、46.4%和8.0%.改进后的ZL107合金不但具有较高的强度和硬度,而且具有良好的塑性,有望成为大型、复杂、高强度结构铸铝件的优选合金之一.     

白花茵陈茎叶中挥发油化学成分的研究

分别采用水蒸气蒸馏和石油醚萃取法提取白花茵陈中的挥发油,并通过GC-MS对其化学成分进行了分析鉴定.结果表明,2种方法提取的挥发油的主要化学成分基本相似,主要为萜烯类及其含氧衍生物（如百里香酚和香荆芥酚）和脂肪酸及其酯等.     

九江城市及郊区麻雀种群数量与空间分布的调查

2003年10月-2004年5月期间对九江城市及郊区麻雀种群数量与空间分布的现状及其历史变迁作了初步调查，结果表明：调查区内麻雀于20世纪80年代初期开始锐减，直至2000年，麻雀又重新出现了明显的恢复迹象，并最终形成以九江县城为消失区、在产粮区罕见以及在九江市区、蔬菜区和产棉区广布的现有空间分布格局．讨论认为这是由于农药及工业性大气污染两个环境因子的综合作用所致．     

Mobile Ad Hoc NetWork与Internet互联的技术研究

分析了移动IP和AODV协议的工作机理．对MANET与Internet互联的关键技术，包括协议转换、地址分配、网关发现、路由发现与数据传输等问题进行了详细的讨论．并对今后的研究工作进行了展望。     

2MgO·2B2O3·MgCl2·14H2O在H3BO3水溶液中相转化平衡溶液的拉曼光谱分析

采用拉曼光谱技术,从溶液结构方面研究了2MgO.2B2O3.MgCl2.14H2O在30℃下5种不同浓度硼酸水溶液中溶解及相转化平衡饱和水溶液中硼氧配阴离子的存在形式,给出了溶液中硼氧配阴离子的拉曼光谱峰归属.结果表明,饱和水溶液中硼氧配阴离子的存在形式分别为H3BO3、B(OH)4-、B3O3(OH)4-、B4O5(OH)42-和B6O7(OH)62-.该研究为2MgO.2B2O3.MgCl2.14H2O在不同浓度硼酸溶液中相转化机理提供了依据.     

二阶三点数值微分公式的外推算法

利用Taylor公式，给出了二阶三点数值微分公式在各点的截断误差的渐近展开式，并利用Richardson外推算法，提高二阶三点数值微分公式的收敛阶数，得到高精度的二阶数值微分公式．     

三七叶甙对兔血小板聚集功能的影响

 应用Born氏比浊法分别测定三七叶甙(Panax notoginseng folium saponins)对花生四烯酸(arachidonic acid,AA)、血小板活化因子(platelet activating factor,PAF)和腺苷二磷酸(adenosine diphosphate,ADP)诱导的兔血小板聚集功能的影响.实验结果表明:三七叶甙在体外显著抑制ADP诱导的血小板聚集,其半数抑制浓度(medium inhibitory concentration,IC₅₀)为89.4mg/L;三七叶甙静脉注射也能明显降低ADP诱导的兔血小板聚集率,且呈剂量-效应关系.提示三七叶甙体内外均明显抑制ADP诱导的兔血小板聚集,而对AA和PAF诱导的兔血小板聚集无明显影响.