Development and validation of UPLC‐MS/MS method for determination of domperidone in human plasma and its pharmacokinetic application

A sensitive, rapid and selective ultra‐performance liquid chromatography–tandem mass spectrometric (UPLC‐MS/MS) method was developed for the determination and pharmacokinetic study of domperidone in human plasma. Diphenhydramine was used as the internal standard. Plasma sample pretreatment involved a one‐step liquid–liquid extraction with a mixture of diethyl ether–dichloromethane (3:2, v/v). The analysis was carried out on an Acquity UPLC^TM BEH C₁₈ column. The mobile phase consisted of methanol–water containing 10 mmol/L ammonium acetate and 0.5% (v/v) formic acid (60:40, v/v). The detection was performed on a triple quadrupole tandem mass spectrometer in multiple reaction monitoring mode via electrospray ionizationsource with positive mode. Each plasma sample was chromatographed within 2.1 min. The standard curves for domperidone were linear (r² ≥ 0.99) over the concentration range of 0.030–31.5 ng/mL with a lower limit of quantification of 0.030 ng/mL. The intra‐ and inter‐day precision (relative standard deviation) values were not higher than 13% and accuracy (relative error) was from ?7.6 to 1.2% at three quality control levels. The method herein described was superior to previous methods and was successfully applied to the pharmacokinetic study of domperidone in healthy Chinese volunteers after oral administration. Copyright © 2012 John Wiley & Sons, Ltd.     

财政农业支出与城乡经济一体化关系实证研究——以广西壮族自治区为例

基于相关分析、协整分析和Granger因果检验以及灰色关联分析等方法,分析了财政农业支出与城乡经济一体化之间的关系。结果表明:(1)财政农业支出与城乡经济一体化之间存在着长期稳定的关系;(2)农业科技三项费用支出与城乡居民人均收入互为原因,第一产业是农业科技三项费用支出的原因;(3)支农支出对城乡经济一体化的作用最大;并且对第一产业的影响最大。另外,加大农业科技三项费用支出也能够加快城乡经济一体化。     

Adsorption of thorium(IV) on magnetic multi-walled carbon nanotubes

The influences of pH, contact time, solid-liquid ratio, temperature and C60(C(COOH)2)n on Th(IV) adsorption onto the magnetic multi-walled carbon nanotubes(MMWCNTs) were studied by batch technique. The dynamic process showed that the adsorption of Th(IV) onto MMWCNTs could reach equilibrium in 40 h and matched the pseudo-second-order kinetics model. The adsorption of Th(IV) onto MMWCNTs was significantly dependent on pH values, the adsorption ratio increased markedly at pH 3.0–5.0, and then maintained a steady state as pH values increased. At low pH, different C60(C(COOH)2)n content could enhance the adsorption content of Th(IV) onto MMWCNTs, but restrained it at higher pH. Through simulating the adsorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich models, it could be seen respectively that the adsorption pattern of Th(IV) onto MMWCNTs was mainly surface complexation, and that the adsorption process was endothermic and irreversible.     

论职业院校的教学文化变革

职业院校的教学文化变革是职业院校教学改革向纵深发展的内在要求.因此,我们一定要树立教学文化变革的开放意识,具备更加广阔的视野,对教学文化变革的内涵、价值和策略进行更加理性的审视,进而形成职业院校的教学品牌文化.     

COD测定废液中Ag2S04的回收循环利用研究

目的研究COD测定废液中Ag2SO4的回收和利用，实现资源的循环利用，提高利用效率，节约实验成本，减少环境污染。方法以COD测定废液为研究对象，将Ag2SO4通过NaCl转化为AgCl沉淀，再用Zn粒在酸性介质中进行还原，使AgCl转化为银粉；所得银粉在少量HN03存在的条件下，用浓H2S04氧化，将其转化为Ag2SO4，重新用于COD测定实验。结果通过一系列实验研究表明，有70％的银可以得到回收，所得Ag2SO4再次用于COD测定实验，标准样品的COD测定误差在许可范围之内；实际污水中COD的测定实验结果表明，Ag2SO4循环使用的测定误差平均为7．4％。结论实验证明回收的Ag2SO4可以作为COD测定实验的催化剂循环使用，可操作性良好，在节约实验成本的基础上，对于环境保护、减少污染物排放量方面有显著效果。但是COD测定结果的偏差较大，重现性有待进一步改进提高。     

Network-based naive Bayes model for social network

Naive Bayes (NB) is one of the most popular classification methods. It is particularly useful when the dimension of the predictor is high and data are generated independently. In the meanwhile, social network data are becoming increasingly accessible, due to the fast development of various social network services and websites. By contrast, data generated by a social network are most likely to be dependent. The dependency is mainly determined by their social network relationships. Then, how to extend the classical NB method to social network data becomes a problem of great interest. To this end, we propose here a network-based naive Bayes (NNB) method, which generalizes the classical NB model to social network data. The key advantage of the NNB method is that it takes the network relationships into consideration. The computational effciency makes the NNB method even feasible in large scale social networks. The statistical properties of the NNB model are theoretically investigated. Simulation studies have been conducted to demonstrate its finite sample performance. A real data example is also analyzed for illustration purpose.     

福建省首届大学生化学实验邀请赛无机及分析化学实验试题解析

介绍了福建省首届大学生化学实验邀请赛无机及分析化学实验的命题思路、试题原题及评分规则,并对实验中存在的问题及成绩进行了总结分析。     

钢-钢纤维混凝土组合桥面板偏心受拉性能

为探究钢-钢纤维混凝土（SFRC）组合桥面板在主梁体系下的偏拉力学特征，分别设计制作了1个普通混凝土组合桥面板和1个SFRC组合桥面板试件进行偏拉试验，并引入材料塑性损伤模型进行有限元模拟，考察了偏拉荷载作用下SFRC对组合桥面板破坏形态、刚度折减、应变分布等力学性能的影响规律。试验及数值分析结果表明，相比普通混凝土，SFRC受拉裂缝数量多但宽度小；通过观测钢筋应变发展及分布可知，由于SFRC具有拉伸硬化特性，在开裂后仍能继续承担外部荷载；SFRC开裂后，其对组合板轴向抗拉刚度与侧向抗弯刚度贡献明显大于普通混凝土；当最大裂缝宽度分别为0.10和0.20 mm时，SFRC对组合板的轴向抗拉刚度贡献为36%和22%，普通混凝土仅为15%和11%;SFRC对组合板的侧向抗弯刚度贡献为41%和27%，普通混凝土仅为29%和17%，表明SFRC开裂后仍可考虑其对组合桥面板刚度贡献。此外，结合理论推导分析了组合板在钢结构全截面屈服时的承载力，结果表明，SFRC和普通混凝土对组合桥面板极限承载力贡献不显著。