页岩气低伤害超临界CO2凝胶压裂液研究

针对常规水压裂液会对页岩造成伤害，容易产生水锁，不易返排，还造成水资源消耗和污染环境等问题，制备了低伤害二氧化碳凝胶压裂液。将自备的F2EU和F4EU增稠剂加入到超临界CO₂基液中，探究两种增稠剂的加入量对CO₂凝胶压裂液黏度的影响，综合考虑成本与效果，优选了2%的F4EU增稠剂，可将CO₂的黏度增至15.4 mPa·s。研究了温度、压力以及剪切速率对凝胶压裂液黏度的影响。实验结果表明，随着温度升高黏度总体降低，但中间出现一个短暂升高阶段；随着压力上升压裂液黏度增加；随着剪切速率的增加压裂液黏度下降，属于一种典型的剪切变稀的假塑性流体。F4EU超临界CO₂凝胶压裂液的平均伤害率为1.39%，远远小于常规压裂液对岩芯的伤害率。实验表明，F4EU超临界CO₂凝胶压裂液在页岩气压裂开采中具有良好的应用前景。     

宁波市公共自行车服务满意度评价模型构建研究

以宁波市公共自行车为例，将因子分析法与二项logistic法相结合，对采集的1 688份居民满意度有效问卷展开分析。利用因子分析法筛选出6个因子，利用二项logistic法剔除并筛选出5个有效因子构建公共自行车服务满意度评价模型，合理评估当前宁波市公共自行车服务满意度。同时，利用随机抽取并不参与建模的5%问卷样本对评价模型进行校验，以确保模型的准确性与合理性。该研究有助于合理评价当前宁波市居民对公共自行车的服务满意度，同时适用于对未来一段时间内公共自行车服务满意度的预测。     

Nb(iPrNPMe2)3Fe–PMe3: A potential high reactivity heterobimetallic catalyst for acetylene cycloadditions

Alkynes cycloaddition reactions are powerful tools for constructing cyclic molecules with optimal atom efficiency, but these reactions cannot proceed at ambient temperature without transition-metal catalysts. In this work, a heterobimetallic complex featuring an Nb–Fe triple bond, Nb(ⁱPrNPMe₂)₃Fe–PMe₃, has been evaluated as the potential catalyst for acetylene cycloaddition, using density functional theory. The calculated results show that the singlet-state (i.e. ground-state) Nb(ⁱPrNPMe₂)₃Fe–PMe₃ can be applied to benzene synthesis, but is not suitable for cyclobutadiene. Benzene can be obtained easily at room temperature and is the unique product on the singlet potential surface. The irradiation of infrared-red light can drive the excitation of singlet Nb(ⁱPrNPMe₂)₃Fe–PMe₃ to its triplet state. Both benzene and cyclobutadiene can be formed on the triplet reaction potential surface due to their low energy barriers. Therefore, Nb(ⁱPrNPMe₂)₃Fe–PMe₃ is a potential high reactivity heterobimetallic catalyst for the cyclotrimerization of alkynes. In the reaction process, the catalytic active site of Nb(ⁱPrNPMe₂)₃Fe–PMe₃ moves from niobium to iron.     

A novel LC–MS/MS method for the determination of ziritaxestat in rat plasma and its pharmacokinetic study

Ziritaxestat is a first-in-class autotoxin inhibitor. The purpose of this study was to develop a liquid chromatography/electrospray ionization tandem mass spectrometric (LC–MS/MS) method for the determination of ziritaxestat in rat plasma. The plasma sample was deproteinated using acetonitrile and then separated on an Acquity BEH C₁₈ column with water containing 0.1% formic acid and acetonitrile as mobile phase, which was delivered at 0.4 ml/min. Ziritaxestat and the internal standard (crizotinib) were quantitatively monitored with precursor-to-product transitions of m/z 589.3 > 262.2 and m/z 450.1 > 260.2, respectively. The total running time was 2.5 min. The method showed excellent linearity over the concentration range 0.5–2000 ng/ml, with correlation coefficient >0.9987. The extraction recovery was >82.09% and the matrix effect was not significant. Inter- and intra-day precisions (RSD) were <11.20% and accuracies were in the range of −8.50–7.45%. Ziritaxestat was demonstrated to be stable in rat plasma under the tested conditions. The validated LC–MS/MS method was successfully applied to study the pharmacokinetic profiles of ziritaxestat in rat plasma after intravenous and oral administration. Pharmacokinetic results demonstrated that ziritaxestat displayed a short half-life (~3 h) and low bioavailability (20.52%).     

基于多变量希尔伯特频域模型的癫痫发作预测

癫痫发作具有突发性和反复性,对患者生命安全构成巨大威胁.为了对癫痫发作进行有效地预测,提出了多变量希尔伯特频域模型的癫痫发作预测方法.将希尔伯特边际谱、希尔伯特边际谱的变化方向和希尔伯特加权频率组成一个三维特征向量作为多变量希尔伯特频域模型,输入到支持相量机中,实现癫痫的发作预测,最后采用癫痫发作预测特征方法对预测结果进行评估.实验结果表明:采用多变量希尔伯特频域模型分析方法预测δ波和θ波的癫痫发作,癫痫预测范围在30~45 min,患者有足够的时间采取措施应对;癫痫发作周期在5~10 min,缩短患者等待时间,降低焦虑程度;与多种相关方法进行比较,该方法具有较低的错误预报率和较高的预测敏感度.     

新建本科院校学科建设的问题及对策

新建本科院校学科建设对提升办学质量具有十分重要的意义。目前新建本科院校学科建设主要存在着学科定位的模糊不清和学科建设的贪大求全等问题。解决这些问题的主要对策是：更新观念，提高认识；科学规划，稳步推进；优化配置，重点突破；形成学科梯队，发挥团队作用；制定规章制度，规范管理机制。     

钢筋混凝土结构板角斜裂缝分析

分析现浇钢筋混凝土结构中经常出现的整个建筑结构阳角楼板的 4 5°上下贯通斜裂缝的产生原因 ,并提出解决问题的设计和施工措施     

多媒体网络环境下数学建模过程探讨

在社会高度信息化的今天 ,多媒体网络为学生的数学建模提供了一个应用现代信息技术的机会 .在多媒体网络环境下开展数学建模可以按照查阅资料 ,模型准备、模拟实验 ,建立模型、数学模型的解、实际问题的解、撰写论文 ,展示成果这样的步骤进行     

研究性学习的人文价值探析

在我国刚刚起步的研究性学习除具有一定的科学价值之外,还具有丰富的人文价值,它可培养学生的主体意识,培养学生健全的人格,促进学生的全面发展,促进每一位学生的发展;其人文价值具有伴随性、生成性、内隐性的特点.     

乙酰胆碱对人胃粘膜上皮细胞和胃腺癌细胞内Ca2+、Mg2+浓度的影响

目的:探讨乙酰胆碱对人胃粘膜上皮细胞和胃腺癌细胞内Ca2 、Mg2 浓度的影响。方法:利用大型生化分析仪,检测了乙酰胆碱作用后培养的人胃粘膜上皮细胞和胃腺癌细胞内Ca2 、Mg2 的浓度。结果:与正常胃粘膜上皮细胞比较,胃腺癌细胞内Ca2 、Mg2 浓度偏低(P>0 01)。在乙酰胆碱作用下,胃粘膜上皮细胞内Ca2 浓度升高(P<0 01),Mg2 浓度降低(P<0 01);胃腺癌细胞仅有Ca2 浓度升高(P<0 05),Mg2 浓度无变化。阿托品能阻断乙酰胆碱的作用(P<0 05)。结论:乙酰胆碱对胃粘膜上皮细胞和胃腺癌细胞的作用是通过毒蕈碱受体实现的。