基于挥手行为的性别识别方法

提出利用挥手行为进行性别识别的方法.使用基于含时切平面的方法检测周期,用平均剪影表征一个周期序列的挥手行为,PCA降维后利用支持向量机进行分类.实验在60人(30男,30女)的数据库上进行.实验结果表明,用提出的算法从三种挥手行为(挥左手、挥右手、挥双手)中识别出性别的正确率达到89.83%或更高.实验还将人体分成5部分:手臂、头肩、腰、臀和腿,研究人体各组成部分对性别识别的贡献.93个对比实验结果表明,去掉手臂部分识别率下降最快;只通过手臂识别正确率达到86.44%或更高;使用两部分识别,手臂+臀部是最优组合;使用三部分识别,手臂+头肩+腰是最优组合.     

运力受扰下的物流无人机干扰恢复模型

为了解决无人机（unmanned aerial vehicle，UAV）运力受扰对末端包裹交付造成的干扰问题，运用干扰管理思想，从客户服务和配送成本角度进行扰动度量，综合考虑无人机能耗、配送时效性、飞行可靠性、飞行安全性等因素建立干扰恢复模型；运用蚁群算法求解问题模型，最后用算例验证本文方案的有效性。结果表明：通过分析3组干扰场景发现，当干扰发生时刻早、受扰客户多时，所建立的恢复模型方案和原始方案对比，可以在短时间内产生新的配送路径，同时以较小的成本代价提高客户服务满意度，实用性更强。     

A rapid and sensitive UPLC–MS/MS method for the determination of zanubrutinib in beagle plasma and its application in pharmacokinetics

A reliable and sensitive ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the determination of zanubrutinib in the plasma of beagle dogs. The column used was an Acquity BEH C₁₈ column (2.1 mm × 50 mm, 1.7 μm), maintained at 40°C with an injection volume of 2 μl. The gradient elution program was as follows: 0–1 min, 10–10% A; 1–1.1 min, 10–90% A; 1.1–2.1 min, 90–90% A; 2.1–2.2 min, 90–10% A; 2.2–3.0 min, 10–10% A. Mobile phase A was 0.1% formic acid, B was acetonitrile, and the total analysis time was 3 min. The mass spectrometry was performed in positive ion mode, and the scanning mode was multi-reaction monitoring mode with electrospray ionization as the ion source; m/z 472.2 → 455.01 for zanubrutinib and m/z 441.03 → 137.99 for ibrutinib (internal standard). The plasma samples were processed by protein precipitation. The standard curve showed good linearity (r² = 0.999 8) in the range of 1.0–1,000 ng/ml (zanubrutinib) with a low limit of quantification of 1 ng/ml. Also, the intra-day and inter-day precision (RSD) was <5.88% and the accuracy (RE) ranged from −1.56 to 1.08%; the recoveries of zanubrutinib in beagle plasma ranged from 90.12 to 93.53% (RSD 1.67–6.42%) and the ME values of zanubrutinib were 98.70–101.06% (RSD 5.37–8.49%, n = 6). All values meet US Food and Drug Administration requirements. A rapid, highly selective and sensitive method for the determination of zanubrutinib concentration in plasma by UPLC–MS/MS was successfully developed. This method is suitable for pharmacokinetic studies in beagle dogs by following oral administration of zanubrutinib.     

Zn的高离化态光谱

用SGV-50型正入射式真空紫外谱仪拍摄了三电极触发火花光源的Zn的高离化光谱。在光谱分析方法研究基础上、对Zn光谱进行了分析。证实了ZnⅢ、ZnⅣ和ZnⅤ的3d~k4s和3d~k4p(k=9,8,7)组态现有光谱的分析结果。通过ZnⅣ3d~84d-3d~84p组态跃迁的分析导出了3d~84d组态的19条能级。     

Programming Super DNA-Enzyme Molecules for On-Demand Enzyme Activity Modulation**

Dynamic interactions of enzymes, including programmable configuration and cycling of enzymes, play important roles in the regulation of cellular metabolism. Here, we constructed a super DNA-enzymes molecule (SDEM) that comprises at least two cascade enzymes and multiple linked DNA strands to control and detect metabolism. We found that the programmable SDEM, which comprises glucose oxidase (GOx) and horseradish peroxidase (HRP), has a 20-fold lower detection limit and a 1.6-fold higher reaction rate than free enzymes. An SDEM can be assembled and disassembled using a hairpin structure and a displacement DNA strand to complete multiple cycles. An entropically driven catalytic assembly (catassembly) enables different SDEMs to switch from an SDEM with GOx and HRP cascades to an SDEM with sarcosine oxidase (SOX) and HRP cascades in over six orders of magnitude less time than without the catassembly to detect different metabolisms (GO and sarcosine) on demand.     

Authentication of Cyathulae Radix and Cyathulae Capitatae Radix based on the strength of the characteristic component achybidensaponin I

Because of the immense difficulty in identifying Cyathulae Capitatae Radix adulteration in Cyathulae Radix, this research aims at fortifying the quality control of Cyathulae Radix and its decoction pieces to guarantee the effectiveness and safety of its clinical use in terms of source material. A method was devised to identify Cyathulae Capitatae Radix adulteration in Cyathulae Radix and its decoction pieces. This research takes achybidensaponin I, that is, the characteristic component of Cyathulae Capitatae Radix, as reference substance and adopts HPLC for detection. The results revealed that, among all samples collected, no trace of achybidensaponin I was found in the 21 batches of Cyathulae Radix, whereas achybidensaponin I was found in all the 14 batches of Cyathulae Capitatae Radix. The research sets 5% as the adulteration limit, that is, 1.45 mg/g Cyathulae Capitatae Radix was detected in 57.14% of the 49 batches of market samples collected and the ratio was 51.02% in the case of 5% adulteration limit. The method is not only precise and reliable but can also be used as a supplement for provisions regarding quality control of Cyathulae Radix and its decoction pieces in Pharmacopoeia of the People's Republic of China, to effectively crack down on Cyathulae Capitatae Radix adulteration in the market.     

地震作用软土震陷特性及变截面群桩动力响应

为研究不同类型地震波作用时软土场地条件下大直径变截面群桩基础的动力响应特性，依托翔安大桥实体工程，通过振动台试验，选取地震动强度均为0.15g的人工合成5010波、1004波，以及Kobe波和El-Centro波，研究了群桩基础桩周土层震陷量、桩身加速度、桩顶水平位移、桩身弯矩等动力响应特性. 结果表明：地震作用下，软土层发生震陷，震陷量为0.16~0.22 cm，其值与输入地震波的频谱特性有关；桩端加速度时程响应曲线较桩顶及变截面处更为“密集”；软土对加速度产生放大效果，输入地震波加速度峰值出现时刻均早于桩端、桩顶及变截面处；桩身加速度及桩顶水平位移分别在1004波和Kobe波作用下达到最大值；5010波和1004波作用下，桩顶产生永久侧向位移；Kobe波作用下，桩身弯矩峰值最大，且弯矩峰值出现时刻最晚. 因此，在进行群桩基础抗震设计时，针对不同桩基特性可选用不同类型地震波进行验算.     

In situ synthesis of Bi3+-doped δ-MnO2 cathode to enhance the cycle stability for aqueous zinc-ion batteries

Journal of Solid State Electrochemistry - Bi3+-doped δ-MnO2 materials (BMX, X = 5, 10, 15) with long cycle life were obtained by an in situ electrochemical reaction using...